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Alpha-1-antitrypsin deficiency and periodontitis, a pilot study

Wallin-Bengtsson, Viveca; Piitulainen, Eeva LU ; Hamberg, Kristina; Lindh, Christina and Bratthall, Gunilla (2011) In Swedish Dental Journal 35(1). p.33-40
Abstract
The aim of this study was to investigate if periodontal parameters and elastase in gingival crevicular fluid (GCF) are different in alpha-1-antitrypsin deficient (AATD) subjects compared to subjects with normal AAT level. Thirty subjects were included, 20 of whom with severe AATD, phenotype PiZZ. Ten AATD subjects suffered from chronic obstructive pulmonary disease (COPD, group 1) and 10 were asymptomatic (group 2). Ten control subjects, phenotype PiMM, (group 3) were recruited from a public dental clinic. The examination comprised of sampling of GCF, Gingival Index (GI), Plaque Index (PII), probing pocket depth (PPD) and radiography. GCF was collected with paper strips (Periopaper (R)). Plasma AAT concentration was measured by... (More)
The aim of this study was to investigate if periodontal parameters and elastase in gingival crevicular fluid (GCF) are different in alpha-1-antitrypsin deficient (AATD) subjects compared to subjects with normal AAT level. Thirty subjects were included, 20 of whom with severe AATD, phenotype PiZZ. Ten AATD subjects suffered from chronic obstructive pulmonary disease (COPD, group 1) and 10 were asymptomatic (group 2). Ten control subjects, phenotype PiMM, (group 3) were recruited from a public dental clinic. The examination comprised of sampling of GCF, Gingival Index (GI), Plaque Index (PII), probing pocket depth (PPD) and radiography. GCF was collected with paper strips (Periopaper (R)). Plasma AAT concentration was measured by nephelometry and AAT in GCF with ELISA. Elastase activity and protein in GCF were determined by spectrophotometry. The mean values for GI, PII, PPD and the radiological measurements did not show any statistically significant differences between the groups. AAT in plasma and GCF demonstrated very low values in groups 1 and 2 with no significant difference between these groups but a statistical difference in comparison with group 3. Elastase in GCF did not show any difference between the three groups. In conclusion, neither the periodontal parameters nor the elastase in GCF were different in AATD subjects, phenotype PiZZ, when compared to subjects with normal AAT level, phenotype PiMM, in this material. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alpha-1-antitrypsin, chronic obstructive pulmonary disease, elastase, gingival crevicular fluid
in
Swedish Dental Journal
volume
35
issue
1
pages
33 - 40
publisher
Sveriges Tandläkarförbund
external identifiers
  • wos:000290981400005
  • scopus:79955626568
ISSN
0347-9994
language
English
LU publication?
yes
id
b469dc95-19ca-4b4f-8dd0-bd79215ab6ef (old id 1985702)
date added to LUP
2011-07-01 09:01:04
date last changed
2017-01-01 06:05:53
@article{b469dc95-19ca-4b4f-8dd0-bd79215ab6ef,
  abstract     = {The aim of this study was to investigate if periodontal parameters and elastase in gingival crevicular fluid (GCF) are different in alpha-1-antitrypsin deficient (AATD) subjects compared to subjects with normal AAT level. Thirty subjects were included, 20 of whom with severe AATD, phenotype PiZZ. Ten AATD subjects suffered from chronic obstructive pulmonary disease (COPD, group 1) and 10 were asymptomatic (group 2). Ten control subjects, phenotype PiMM, (group 3) were recruited from a public dental clinic. The examination comprised of sampling of GCF, Gingival Index (GI), Plaque Index (PII), probing pocket depth (PPD) and radiography. GCF was collected with paper strips (Periopaper (R)). Plasma AAT concentration was measured by nephelometry and AAT in GCF with ELISA. Elastase activity and protein in GCF were determined by spectrophotometry. The mean values for GI, PII, PPD and the radiological measurements did not show any statistically significant differences between the groups. AAT in plasma and GCF demonstrated very low values in groups 1 and 2 with no significant difference between these groups but a statistical difference in comparison with group 3. Elastase in GCF did not show any difference between the three groups. In conclusion, neither the periodontal parameters nor the elastase in GCF were different in AATD subjects, phenotype PiZZ, when compared to subjects with normal AAT level, phenotype PiMM, in this material.},
  author       = {Wallin-Bengtsson, Viveca and Piitulainen, Eeva and Hamberg, Kristina and Lindh, Christina and Bratthall, Gunilla},
  issn         = {0347-9994},
  keyword      = {Alpha-1-antitrypsin,chronic obstructive pulmonary disease,elastase,gingival crevicular fluid},
  language     = {eng},
  number       = {1},
  pages        = {33--40},
  publisher    = {Sveriges Tandläkarförbund},
  series       = {Swedish Dental Journal},
  title        = {Alpha-1-antitrypsin deficiency and periodontitis, a pilot study},
  volume       = {35},
  year         = {2011},
}