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Use of antipsychotics - An analysis of lifetime treatment in 66 patients with psychoses

Jonsson, Erik G.; Saetre, Peter; Vares, Maria; Stralin, Pontus; Levander, Sten LU and Lindstrom, Eva (2011) In Psychiatry Research 187(1-2). p.80-88
Abstract
Only a minority of patients treated with antipsychotics in clinical studies continue their treatments throughout a longer study period. Few studies address this issue from a lifetime perspective. In this naturalistic study, we aimed at analysing the prescription pattern of antipsychotic drugs among a sample of Swedish patients with a diagnosis of psychotic illness, from the first contact with psychiatry (typically between 1973 and 1997) until the last written note in the case history documents. A retrospective descriptive analysis was performed of all case history data of 66 patients diagnosed with schizophrenia or related psychotic disorders. Patients with schizophrenia were prescribed antipsychotic medication more than 90% of the time.... (More)
Only a minority of patients treated with antipsychotics in clinical studies continue their treatments throughout a longer study period. Few studies address this issue from a lifetime perspective. In this naturalistic study, we aimed at analysing the prescription pattern of antipsychotic drugs among a sample of Swedish patients with a diagnosis of psychotic illness, from the first contact with psychiatry (typically between 1973 and 1997) until the last written note in the case history documents. A retrospective descriptive analysis was performed of all case history data of 66 patients diagnosed with schizophrenia or related psychotic disorders. Patients with schizophrenia were prescribed antipsychotic medication more than 90% of the time. Each patient generally had been prescribed several (up to 16) different antipsychotic drugs and a quarter of the patients had been prescribed two or more antipsychotics for a third of their prescription time. Patients with psychosis were exposed to a cumulatively growing number of antipsychotics. Various factors, including clinician and patient expectations, and specific strengths and limitations of available antipsychotics may account for frequent medication changes over time. (C) 2010 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antipsychotic drugs, Schizophrenia, Retrospective, Poly-pharmacy, Lifetime
in
Psychiatry Research
volume
187
issue
1-2
pages
80 - 88
publisher
Elsevier
external identifiers
  • wos:000290183700014
  • scopus:79953125603
ISSN
1872-7123
DOI
10.1016/j.psychres.2010.10.027
language
English
LU publication?
yes
id
25d9051c-c9a1-49a6-8370-72d57d1aa55f (old id 1986657)
date added to LUP
2011-07-01 09:11:11
date last changed
2017-01-01 03:18:17
@article{25d9051c-c9a1-49a6-8370-72d57d1aa55f,
  abstract     = {Only a minority of patients treated with antipsychotics in clinical studies continue their treatments throughout a longer study period. Few studies address this issue from a lifetime perspective. In this naturalistic study, we aimed at analysing the prescription pattern of antipsychotic drugs among a sample of Swedish patients with a diagnosis of psychotic illness, from the first contact with psychiatry (typically between 1973 and 1997) until the last written note in the case history documents. A retrospective descriptive analysis was performed of all case history data of 66 patients diagnosed with schizophrenia or related psychotic disorders. Patients with schizophrenia were prescribed antipsychotic medication more than 90% of the time. Each patient generally had been prescribed several (up to 16) different antipsychotic drugs and a quarter of the patients had been prescribed two or more antipsychotics for a third of their prescription time. Patients with psychosis were exposed to a cumulatively growing number of antipsychotics. Various factors, including clinician and patient expectations, and specific strengths and limitations of available antipsychotics may account for frequent medication changes over time. (C) 2010 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Jonsson, Erik G. and Saetre, Peter and Vares, Maria and Stralin, Pontus and Levander, Sten and Lindstrom, Eva},
  issn         = {1872-7123},
  keyword      = {Antipsychotic drugs,Schizophrenia,Retrospective,Poly-pharmacy,Lifetime},
  language     = {eng},
  number       = {1-2},
  pages        = {80--88},
  publisher    = {Elsevier},
  series       = {Psychiatry Research},
  title        = {Use of antipsychotics - An analysis of lifetime treatment in 66 patients with psychoses},
  url          = {http://dx.doi.org/10.1016/j.psychres.2010.10.027},
  volume       = {187},
  year         = {2011},
}