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TAR-DNA binding protein-43 and alterations in the hippocampus

Rauramaa, Tuomas; Pikkarainen, Maria; Englund, Elisabet LU ; Ince, Paul G.; Jellinger, Kurt; Paetau, Anders and Alafuzoff, Irina (2011) In Journal of Neural Transmission 118(5). p.683-689
Abstract
Immunocytochemistry for transactive response binding protein-43 (TDP43) was assessed in the granular cell layer of the dentate gyrus in 250 cases displaying hippocampal pathology identified by haematoxylin-eosin staining. 18%, nearly one in five displayed TDP43 immunoreactive pathology in the granular cell layer of hippocampus. This percentage increased to 43% when only subjects with hippocampal pathology other than vascular in origin were included. When only subjects with severe Alzheimer's disease-related pathology were included, 42% displayed TDP43-immunoreactive pathology, increasing to 60% when concomitant Alzheimer's disease and alpha-synuclein pathology were present. Within this setting, TDP43-immunoreactive pathology was observed... (More)
Immunocytochemistry for transactive response binding protein-43 (TDP43) was assessed in the granular cell layer of the dentate gyrus in 250 cases displaying hippocampal pathology identified by haematoxylin-eosin staining. 18%, nearly one in five displayed TDP43 immunoreactive pathology in the granular cell layer of hippocampus. This percentage increased to 43% when only subjects with hippocampal pathology other than vascular in origin were included. When only subjects with severe Alzheimer's disease-related pathology were included, 42% displayed TDP43-immunoreactive pathology, increasing to 60% when concomitant Alzheimer's disease and alpha-synuclein pathology were present. Within this setting, TDP43-immunoreactive pathology was observed to be present in 6% of subjects with hippocampal pathology but without any cognitive impairment. Our findings justify assessment of TDP43 pathology in every case where a pathological alteration is observed in the hippocampus using a routine stain. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
TAR-DNA binding protein-43, Hyperphosphorylated-tau, p62, Immunohistochemistry, Post-mortem, Hippocampal alterations
in
Journal of Neural Transmission
volume
118
issue
5
pages
683 - 689
publisher
Springer
external identifiers
  • wos:000290542500005
  • scopus:79956214776
ISSN
0300-9564
DOI
10.1007/s00702-010-0574-5
language
English
LU publication?
yes
id
a9bd3781-fea7-4253-991b-746e3617176f (old id 1986799)
date added to LUP
2011-07-01 09:20:10
date last changed
2017-09-24 04:10:06
@article{a9bd3781-fea7-4253-991b-746e3617176f,
  abstract     = {Immunocytochemistry for transactive response binding protein-43 (TDP43) was assessed in the granular cell layer of the dentate gyrus in 250 cases displaying hippocampal pathology identified by haematoxylin-eosin staining. 18%, nearly one in five displayed TDP43 immunoreactive pathology in the granular cell layer of hippocampus. This percentage increased to 43% when only subjects with hippocampal pathology other than vascular in origin were included. When only subjects with severe Alzheimer's disease-related pathology were included, 42% displayed TDP43-immunoreactive pathology, increasing to 60% when concomitant Alzheimer's disease and alpha-synuclein pathology were present. Within this setting, TDP43-immunoreactive pathology was observed to be present in 6% of subjects with hippocampal pathology but without any cognitive impairment. Our findings justify assessment of TDP43 pathology in every case where a pathological alteration is observed in the hippocampus using a routine stain.},
  author       = {Rauramaa, Tuomas and Pikkarainen, Maria and Englund, Elisabet and Ince, Paul G. and Jellinger, Kurt and Paetau, Anders and Alafuzoff, Irina},
  issn         = {0300-9564},
  keyword      = {TAR-DNA binding protein-43,Hyperphosphorylated-tau,p62,Immunohistochemistry,Post-mortem,Hippocampal alterations},
  language     = {eng},
  number       = {5},
  pages        = {683--689},
  publisher    = {Springer},
  series       = {Journal of Neural Transmission},
  title        = {TAR-DNA binding protein-43 and alterations in the hippocampus},
  url          = {http://dx.doi.org/10.1007/s00702-010-0574-5},
  volume       = {118},
  year         = {2011},
}