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Correlation between Stated and Measured Concentrations of Acrylate and Methacrylate Allergens in Patch-Test Preparations

Goon, Anthony LU ; Bruze, Magnus LU ; Zimerson, Erik LU ; Sörensen, Östen LU ; Goh, Chee-Leok; Koh, David Soo-Quee and Isaksson, Marléne LU (2011) In Dermatitis 22(1). p.27-32
Abstract
Background: Contact allergy to acrylates and methacrylates is not uncommon. The allergy is confirmed by patch-testing patients with commercial patch-test preparations. Objective: To investigate acrylate and methacrylate allergens used for patch testing in nine different dermatology departments from Europe, America, Asia, and Australia. Methods: The acrylate and methacrylate (methyl methacrylate, 2-hydroxypropyl acrylate, 2-hydroxyethyl methacrylate, ethylene glycol dimethacrylate, and triethylene glycol diacrylate) allergen samples were analyzed with high-performance liquid chromatography to measure the allergen content. Results: Variation in measured versus stated concentrations was seen in these samples. The ratio of measured to stated... (More)
Background: Contact allergy to acrylates and methacrylates is not uncommon. The allergy is confirmed by patch-testing patients with commercial patch-test preparations. Objective: To investigate acrylate and methacrylate allergens used for patch testing in nine different dermatology departments from Europe, America, Asia, and Australia. Methods: The acrylate and methacrylate (methyl methacrylate, 2-hydroxypropyl acrylate, 2-hydroxyethyl methacrylate, ethylene glycol dimethacrylate, and triethylene glycol diacrylate) allergen samples were analyzed with high-performance liquid chromatography to measure the allergen content. Results: Variation in measured versus stated concentrations was seen in these samples. The ratio of measured to stated concentrations ranged from 0.11 to 1.1. Only 22 (63%) of 35 samples were within the arbitrary acceptable limits of 80 to 120% of the stated concentrations. Conclusion: The results may have implications for individual diagnosis and prevention and when test results from various centers are compared. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dermatitis
volume
22
issue
1
pages
27 - 32
publisher
BC Decker
external identifiers
  • wos:000290468700004
  • scopus:79951483001
ISSN
1532-8163
DOI
10.2310/6620.2011.10083
language
English
LU publication?
yes
id
eff34333-5cd7-4c67-9921-2f1af5868f76 (old id 1986897)
date added to LUP
2011-07-01 09:21:17
date last changed
2017-01-01 03:09:10
@article{eff34333-5cd7-4c67-9921-2f1af5868f76,
  abstract     = {Background: Contact allergy to acrylates and methacrylates is not uncommon. The allergy is confirmed by patch-testing patients with commercial patch-test preparations. Objective: To investigate acrylate and methacrylate allergens used for patch testing in nine different dermatology departments from Europe, America, Asia, and Australia. Methods: The acrylate and methacrylate (methyl methacrylate, 2-hydroxypropyl acrylate, 2-hydroxyethyl methacrylate, ethylene glycol dimethacrylate, and triethylene glycol diacrylate) allergen samples were analyzed with high-performance liquid chromatography to measure the allergen content. Results: Variation in measured versus stated concentrations was seen in these samples. The ratio of measured to stated concentrations ranged from 0.11 to 1.1. Only 22 (63%) of 35 samples were within the arbitrary acceptable limits of 80 to 120% of the stated concentrations. Conclusion: The results may have implications for individual diagnosis and prevention and when test results from various centers are compared.},
  author       = {Goon, Anthony and Bruze, Magnus and Zimerson, Erik and Sörensen, Östen and Goh, Chee-Leok and Koh, David Soo-Quee and Isaksson, Marléne},
  issn         = {1532-8163},
  language     = {eng},
  number       = {1},
  pages        = {27--32},
  publisher    = {BC Decker},
  series       = {Dermatitis},
  title        = {Correlation between Stated and Measured Concentrations of Acrylate and Methacrylate Allergens in Patch-Test Preparations},
  url          = {http://dx.doi.org/10.2310/6620.2011.10083},
  volume       = {22},
  year         = {2011},
}