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Expression of apolipoprotein M in human hepatocellular carcinoma tissues

Jiang, Jingting; Wu, Changping; Luo, Guanghua; Zheng, Lu; Chen, Lujun; Zhang, Xiaoying and Xu, Ning LU (2011) In Acta Histochemica 113(1). p.53-57
Abstract
The present study examined mRNA levels and protein mass of apolipoprotein M (apoM) in human hepatocellular carcinoma (HCC) tissues and in the adjacent tissues. Plasma apoM levels in these HCC patients were also determined and compared to the normal subjects. The mean level of plasma apoM in the HCC patients was 0.61 +/- 0.30 OD mm(-2), which was significantly higher than that in the normal subjects 0.37 +/- 0.07 OD mm(-2) (P < 0.01). However, both apoM mRNA levels and apoM protein mass in the HCC tissues were significantly lower than in the adjacent tissues (P < 0.05). It is concluded that human hepatocellular carcinoma tissues had a reduced capacity to produce apoM than the adjacent non-tumor tissues. However, the plasma apoM levels... (More)
The present study examined mRNA levels and protein mass of apolipoprotein M (apoM) in human hepatocellular carcinoma (HCC) tissues and in the adjacent tissues. Plasma apoM levels in these HCC patients were also determined and compared to the normal subjects. The mean level of plasma apoM in the HCC patients was 0.61 +/- 0.30 OD mm(-2), which was significantly higher than that in the normal subjects 0.37 +/- 0.07 OD mm(-2) (P < 0.01). However, both apoM mRNA levels and apoM protein mass in the HCC tissues were significantly lower than in the adjacent tissues (P < 0.05). It is concluded that human hepatocellular carcinoma tissues had a reduced capacity to produce apoM than the adjacent non-tumor tissues. However, the plasma apoM levels were higher in the HCC patients than in normal subjects, which suggested that tissues adjacent to the tumors or extra-hepatic apoM production in the HCC patients may contribute to the higher plasma apoM levels in these patients. The clinical significance of apoM in relation to HCC still needs further investigation. (C) 2009 Published by Elsevier GmbH. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
keywords
Apolipoprotein M, Hepatocellular carcinoma, Immunohistochemistry, Human
in
Acta Histochemica
volume
113
issue
1
pages
53 - 57
publisher
Elsevier
external identifiers
  • wos:000290425900010
  • scopus:78649821573
ISSN
0065-1281
DOI
10.1016/j.acthis.2009.08.005
language
English
LU publication?
yes
id
54bcd668-3e03-4c5c-bc5f-8bf298e99890 (old id 1988230)
date added to LUP
2011-07-01 09:31:27
date last changed
2017-01-01 03:13:28
@article{54bcd668-3e03-4c5c-bc5f-8bf298e99890,
  abstract     = {The present study examined mRNA levels and protein mass of apolipoprotein M (apoM) in human hepatocellular carcinoma (HCC) tissues and in the adjacent tissues. Plasma apoM levels in these HCC patients were also determined and compared to the normal subjects. The mean level of plasma apoM in the HCC patients was 0.61 +/- 0.30 OD mm(-2), which was significantly higher than that in the normal subjects 0.37 +/- 0.07 OD mm(-2) (P &lt; 0.01). However, both apoM mRNA levels and apoM protein mass in the HCC tissues were significantly lower than in the adjacent tissues (P &lt; 0.05). It is concluded that human hepatocellular carcinoma tissues had a reduced capacity to produce apoM than the adjacent non-tumor tissues. However, the plasma apoM levels were higher in the HCC patients than in normal subjects, which suggested that tissues adjacent to the tumors or extra-hepatic apoM production in the HCC patients may contribute to the higher plasma apoM levels in these patients. The clinical significance of apoM in relation to HCC still needs further investigation. (C) 2009 Published by Elsevier GmbH.},
  author       = {Jiang, Jingting and Wu, Changping and Luo, Guanghua and Zheng, Lu and Chen, Lujun and Zhang, Xiaoying and Xu, Ning},
  issn         = {0065-1281},
  keyword      = {Apolipoprotein M,Hepatocellular carcinoma,Immunohistochemistry,Human},
  language     = {eng},
  number       = {1},
  pages        = {53--57},
  publisher    = {Elsevier},
  series       = {Acta Histochemica},
  title        = {Expression of apolipoprotein M in human hepatocellular carcinoma tissues},
  url          = {http://dx.doi.org/10.1016/j.acthis.2009.08.005},
  volume       = {113},
  year         = {2011},
}