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Rangelia vitalii : changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs

Costa, Márcio Machado ; França, Raqueli Teresinha ; Da Silva, Aleksandro Schafer ; Paim, Carlos Breno ; Paim, Francine ; do Amaral, Carlos Henrique ; Dornelles, Guilherme Lopes ; da Cunha, João Paulo Monteiro Carvalho Mori LU orcid ; Soares, João Fabio and Labruna, Marcelo Bahia , et al. (2012) In Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria 21(3). p.243-248
Abstract

Rangelia vitalii is a protozoon that causes diseases in dogs, and anemia is the most common laboratory finding. However, few studies on the biochemical changes in dogs infected with this protozoon exist. Thus, this study aimed to investigate the biochemical changes in dogs experimentally infected with R. vitalii, during the acute phase of the infection. For this study, 12 female dogs (aged 6-12 months and weighing between 4 and 7 kg) were used, divided in two groups. Group A was composed of healthy dogs (n = 5); and group B consisted of infected animals (n = 7). Blood samples were collected on days 0, 10, 20 and 30 after infection, using tubes without anticoagulant to obtain serum and analyze the biochemical parameters. An increase in... (More)

Rangelia vitalii is a protozoon that causes diseases in dogs, and anemia is the most common laboratory finding. However, few studies on the biochemical changes in dogs infected with this protozoon exist. Thus, this study aimed to investigate the biochemical changes in dogs experimentally infected with R. vitalii, during the acute phase of the infection. For this study, 12 female dogs (aged 6-12 months and weighing between 4 and 7 kg) were used, divided in two groups. Group A was composed of healthy dogs (n = 5); and group B consisted of infected animals (n = 7). Blood samples were collected on days 0, 10, 20 and 30 after infection, using tubes without anticoagulant to obtain serum and analyze the biochemical parameters. An increase in alanine aminotransferase (ALT) on day 20 (P < 0.05) was observed. Also, increased creatine kinase (CK) and aspartate aminotransferase (AST) levels were observed throughout the experimental period (P < 0.05). No changes in the serum gamma-glutamyltransferase, urea and creatinine levels were observed. Thus, is possible to conclude that experimental infection with R. vitalii in dogs causes changes to the biochemical profile, with increased ALT, AST and CK enzyme levels.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acute Disease, Alanine Transaminase/blood, Animals, Aspartate Aminotransferases/blood, Creatine Kinase/blood, Dog Diseases/blood, Dogs, Female, Protozoan Infections, Animal/blood
in
Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria
volume
21
issue
3
pages
6 pages
publisher
BRAZILIAN COLL VETERINARY PARASITOLOGY
external identifiers
  • pmid:23070434
  • scopus:84867545593
ISSN
0103-846X
DOI
10.1590/S1984-29612012000300012
language
English
LU publication?
no
id
19afc325-a5f5-47d2-94ca-bc0fcc1ab577
date added to LUP
2019-02-14 09:19:58
date last changed
2024-05-28 04:13:39
@article{19afc325-a5f5-47d2-94ca-bc0fcc1ab577,
  abstract     = {{<p>Rangelia vitalii is a protozoon that causes diseases in dogs, and anemia is the most common laboratory finding. However, few studies on the biochemical changes in dogs infected with this protozoon exist. Thus, this study aimed to investigate the biochemical changes in dogs experimentally infected with R. vitalii, during the acute phase of the infection. For this study, 12 female dogs (aged 6-12 months and weighing between 4 and 7 kg) were used, divided in two groups. Group A was composed of healthy dogs (n = 5); and group B consisted of infected animals (n = 7). Blood samples were collected on days 0, 10, 20 and 30 after infection, using tubes without anticoagulant to obtain serum and analyze the biochemical parameters. An increase in alanine aminotransferase (ALT) on day 20 (P &lt; 0.05) was observed. Also, increased creatine kinase (CK) and aspartate aminotransferase (AST) levels were observed throughout the experimental period (P &lt; 0.05). No changes in the serum gamma-glutamyltransferase, urea and creatinine levels were observed. Thus, is possible to conclude that experimental infection with R. vitalii in dogs causes changes to the biochemical profile, with increased ALT, AST and CK enzyme levels.</p>}},
  author       = {{Costa, Márcio Machado and França, Raqueli Teresinha and Da Silva, Aleksandro Schafer and Paim, Carlos Breno and Paim, Francine and do Amaral, Carlos Henrique and Dornelles, Guilherme Lopes and da Cunha, João Paulo Monteiro Carvalho Mori and Soares, João Fabio and Labruna, Marcelo Bahia and Mazzanti, Cinthia Melazzo Andrade and Monteiro, Silvia Gonzalez and Lopes, Sonia Terezinha Dos Anjos}},
  issn         = {{0103-846X}},
  keywords     = {{Acute Disease; Alanine Transaminase/blood; Animals; Aspartate Aminotransferases/blood; Creatine Kinase/blood; Dog Diseases/blood; Dogs; Female; Protozoan Infections, Animal/blood}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{3}},
  pages        = {{243--248}},
  publisher    = {{BRAZILIAN COLL VETERINARY PARASITOLOGY}},
  series       = {{Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria}},
  title        = {{Rangelia vitalii : changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs}},
  url          = {{http://dx.doi.org/10.1590/S1984-29612012000300012}},
  doi          = {{10.1590/S1984-29612012000300012}},
  volume       = {{21}},
  year         = {{2012}},
}