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Association of cancer with moderately impaired renal function at baseline in a large, representative, population-based cohort followed for up to 30 years.

Christensson, Anders LU ; Savage, Caroline; Sjöberg, Daniel; Cronin, Angel M; O'Brien, M Frank; Lowrance, William; Nilsson, Peter LU ; Vickers, Andrew J; Russo, Paul and Lilja, Hans LU (2013) In International Journal of Cancer 133(6). p.1452-1458
Abstract
Patients with chronic renal failure show a greater incidence of malignancies. We evaluated whether moderately impaired renal function at baseline influenced risk of all cancers during long-term follow in young persons. Our cohort included 33,346 subjects, aged 26-61 years at baseline, in a representative, population-based study enrolling subjects from 1974 to 1992. Median follow-up time was 28 years. Plasma creatinine was analysed as a single measure at baseline. Incident cases of cancer were identified from the Swedish Cancer Registry. We studied 24,552 subjects from the cohort. To account for the unique sampling design, participants were divided by sex and age at baseline into 1,132 older men (age 60), 14,254 younger men (age 40-52),... (More)
Patients with chronic renal failure show a greater incidence of malignancies. We evaluated whether moderately impaired renal function at baseline influenced risk of all cancers during long-term follow in young persons. Our cohort included 33,346 subjects, aged 26-61 years at baseline, in a representative, population-based study enrolling subjects from 1974 to 1992. Median follow-up time was 28 years. Plasma creatinine was analysed as a single measure at baseline. Incident cases of cancer were identified from the Swedish Cancer Registry. We studied 24,552 subjects from the cohort. To account for the unique sampling design, participants were divided by sex and age at baseline into 1,132 older men (age 60), 14,254 younger men (age 40-52), 7,498 older women (age 47-57) and 1,688 younger women (age 35-43). Glomerular filtration rate (GFR) was estimated using the CKD-EPI formula. Patients were classified as having either normal to mildly impaired kidney function (eGFR≥60 mL/min/1.73m(2) ), or moderate kidney dysfunction (eGFR<60 mL/min/1.73m(2) ). We calculated the risk of all cancers using competing risks regression. Overall, 6,595 participants were diagnosed with cancer, and 854 subjects (3.5%) had moderately impaired renal dysfunction at baseline. There was a significant association between moderately decreased GFR and subsequent risk of kidney cancer in younger men (hazard ratio, 3.38; 95% CI, 1.48 to 7.71; P=0.004). However, we found no association with overall long-term cancer risk. Our confirmation of an association between moderately impaired renal function and risk of kidney cancer in younger men requires further exploration of high-risk groups and biological mechanisms. © 2013 Wiley Periodicals, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
133
issue
6
pages
1452 - 1458
publisher
John Wiley & Sons
external identifiers
  • wos:000321436300019
  • pmid:23463659
  • scopus:84879939905
ISSN
0020-7136
DOI
10.1002/ijc.28144
language
English
LU publication?
yes
id
19b76800-6dff-40c8-a12f-d6247a96e7e6 (old id 3628574)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23463659?dopt=Abstract
date added to LUP
2013-04-04 12:34:35
date last changed
2019-02-27 01:27:21
@article{19b76800-6dff-40c8-a12f-d6247a96e7e6,
  abstract     = {Patients with chronic renal failure show a greater incidence of malignancies. We evaluated whether moderately impaired renal function at baseline influenced risk of all cancers during long-term follow in young persons. Our cohort included 33,346 subjects, aged 26-61 years at baseline, in a representative, population-based study enrolling subjects from 1974 to 1992. Median follow-up time was 28 years. Plasma creatinine was analysed as a single measure at baseline. Incident cases of cancer were identified from the Swedish Cancer Registry. We studied 24,552 subjects from the cohort. To account for the unique sampling design, participants were divided by sex and age at baseline into 1,132 older men (age 60), 14,254 younger men (age 40-52), 7,498 older women (age 47-57) and 1,688 younger women (age 35-43). Glomerular filtration rate (GFR) was estimated using the CKD-EPI formula. Patients were classified as having either normal to mildly impaired kidney function (eGFR≥60 mL/min/1.73m(2) ), or moderate kidney dysfunction (eGFR&lt;60 mL/min/1.73m(2) ). We calculated the risk of all cancers using competing risks regression. Overall, 6,595 participants were diagnosed with cancer, and 854 subjects (3.5%) had moderately impaired renal dysfunction at baseline. There was a significant association between moderately decreased GFR and subsequent risk of kidney cancer in younger men (hazard ratio, 3.38; 95% CI, 1.48 to 7.71; P=0.004). However, we found no association with overall long-term cancer risk. Our confirmation of an association between moderately impaired renal function and risk of kidney cancer in younger men requires further exploration of high-risk groups and biological mechanisms. © 2013 Wiley Periodicals, Inc.},
  author       = {Christensson, Anders and Savage, Caroline and Sjöberg, Daniel and Cronin, Angel M and O'Brien, M Frank and Lowrance, William and Nilsson, Peter and Vickers, Andrew J and Russo, Paul and Lilja, Hans},
  issn         = {0020-7136},
  language     = {eng},
  number       = {6},
  pages        = {1452--1458},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Association of cancer with moderately impaired renal function at baseline in a large, representative, population-based cohort followed for up to 30 years.},
  url          = {http://dx.doi.org/10.1002/ijc.28144},
  volume       = {133},
  year         = {2013},
}