The influence of the major histocompatibility complex (H-2) on experimental diabetes in mice
Kromann, H. ; Lernmark, Å LU
; Vestergaard, B. F.
; Egeberg, J.
and Nerup, J.
LU
(1979)
In Diabetologia
16(2).
p.107-114
- Abstract
Mice with different histocompatibility loci on an identical background genome (congenic resistant lines of mice) were used to study the possible influence of the histocompatibility complex on experimental diabetes. The major histocompatibility complex (H-2) was not found to influence the diabetogenic effect of encephalomyocarditis (EMC) virus. In contrast the glucose intolerance following heterologous and homologous immunization with pancreatic antigens appeared H-2 influenced. Antibodies against cell surface components on viable B-cells were present in serum from mice with glucose intolerance induced by homologous immunization. The results suggest that the susceptibility to experimental autoimmune diabetes in mice is influenced by the... (More)
Mice with different histocompatibility loci on an identical background genome (congenic resistant lines of mice) were used to study the possible influence of the histocompatibility complex on experimental diabetes. The major histocompatibility complex (H-2) was not found to influence the diabetogenic effect of encephalomyocarditis (EMC) virus. In contrast the glucose intolerance following heterologous and homologous immunization with pancreatic antigens appeared H-2 influenced. Antibodies against cell surface components on viable B-cells were present in serum from mice with glucose intolerance induced by homologous immunization. The results suggest that the susceptibility to experimental autoimmune diabetes in mice is influenced by the H-2 complex.
(Less)
- author
- Kromann, H.
; Lernmark, Å
LU
; Vestergaard, B. F.
; Egeberg, J.
and Nerup, J.
LU
- publishing date
- 1979-02-01
- type
- Contribution to journal
- publication status
- published
- keywords
- autoimmunity, Experimental diabetes mellitus, glucose intolerance, immune response genes, islet-cell-surface antibody, major histocompatibility locus, virus
- in
- Diabetologia
- volume
- 16
- issue
- 2
- pages
- 8 pages
- publisher
- Springer
- external identifiers
-
- scopus:0018746918
- pmid:215479
- ISSN
- 0012-186X
- DOI
- 10.1007/BF01225459
- language
- English
- LU publication?
- no
- id
- 19bf4f33-f856-4fee-ada3-c9448c15a275
- date added to LUP
- 2019-09-18 12:05:42
- date last changed
- 2024-03-13 08:10:08
@article{19bf4f33-f856-4fee-ada3-c9448c15a275,
abstract = {{<p>Mice with different histocompatibility loci on an identical background genome (congenic resistant lines of mice) were used to study the possible influence of the histocompatibility complex on experimental diabetes. The major histocompatibility complex (H-2) was not found to influence the diabetogenic effect of encephalomyocarditis (EMC) virus. In contrast the glucose intolerance following heterologous and homologous immunization with pancreatic antigens appeared H-2 influenced. Antibodies against cell surface components on viable B-cells were present in serum from mice with glucose intolerance induced by homologous immunization. The results suggest that the susceptibility to experimental autoimmune diabetes in mice is influenced by the H-2 complex.</p>}},
author = {{Kromann, H. and Lernmark, Å and Vestergaard, B. F. and Egeberg, J. and Nerup, J.}},
issn = {{0012-186X}},
keywords = {{autoimmunity; Experimental diabetes mellitus; glucose intolerance; immune response genes; islet-cell-surface antibody; major histocompatibility locus; virus}},
language = {{eng}},
month = {{02}},
number = {{2}},
pages = {{107--114}},
publisher = {{Springer}},
series = {{Diabetologia}},
title = {{The influence of the major histocompatibility complex (H-2) on experimental diabetes in mice}},
url = {{http://dx.doi.org/10.1007/BF01225459}},
doi = {{10.1007/BF01225459}},
volume = {{16}},
year = {{1979}},
}