Written pretest information and germline BRCA1/2 pathogenic variant testing in unselected breast cancer patients : predictors of testing uptake
(2019) In Genetics in Medicine 21(1). p.89-96- Abstract
Purpose: This study aimed to evaluate predictors of testing uptake among unselected breast cancer patients who were offered germline BRCA1/2 testing in a prospective study. Methods: Pretest information was provided by a standardized invitation letter instead of in-person counseling. Data was abstracted from medical records. Using multivariate logistic regressions, predictors of testing uptake were analyzed. Results: The overall uptake of testing was 67% (539 of 805 patients). Low uptake rates were found for patients aged ≥80 years (33%), and patients born outside of Europe (37%). In adjusted analysis, age ≥80 years (odds ratio [OR] 0.10; P = 0.002), psychiatric disorders (OR 0.46; P = 0.006), occupation requiring at least 3 years of... (More)
Purpose: This study aimed to evaluate predictors of testing uptake among unselected breast cancer patients who were offered germline BRCA1/2 testing in a prospective study. Methods: Pretest information was provided by a standardized invitation letter instead of in-person counseling. Data was abstracted from medical records. Using multivariate logistic regressions, predictors of testing uptake were analyzed. Results: The overall uptake of testing was 67% (539 of 805 patients). Low uptake rates were found for patients aged ≥80 years (33%), and patients born outside of Europe (37%). In adjusted analysis, age ≥80 years (odds ratio [OR] 0.10; P = 0.002), psychiatric disorders (OR 0.46; P = 0.006), occupation requiring at least 3 years of university or college education (OR 2.03; P = 0.003), and breast cancer or ovarian cancer in first-degree or second-degree relatives (OR 1.66; P = 0.02) were independently associated with uptake of BRCA1/2 testing. Somatic comorbidity in patients aged <70 years was associated with lower testing uptake. Conclusion: Testing uptake varies across different subgroups according to patient-related factors that are readily available in the medical records. Knowledge about these factors enables health care professionals to identify patients who are less likely to pursue genetic testing.
(Less)
- author
- Nilsson, Martin P. LU ; Nilsson, Erik D. LU ; Silfverberg, Barbro ; Borg, Åke LU and Loman, Niklas LU
- organization
- publishing date
- 2019-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Genetics in Medicine
- volume
- 21
- issue
- 1
- pages
- 89 - 96
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:29875420
- scopus:85048081325
- ISSN
- 1098-3600
- DOI
- 10.1038/s41436-018-0021-9
- language
- English
- LU publication?
- yes
- id
- 19eba192-8725-4ed5-adfb-221708d871bc
- date added to LUP
- 2018-06-18 16:11:11
- date last changed
- 2024-08-19 19:39:43
@article{19eba192-8725-4ed5-adfb-221708d871bc, abstract = {{<p>Purpose: This study aimed to evaluate predictors of testing uptake among unselected breast cancer patients who were offered germline BRCA1/2 testing in a prospective study. Methods: Pretest information was provided by a standardized invitation letter instead of in-person counseling. Data was abstracted from medical records. Using multivariate logistic regressions, predictors of testing uptake were analyzed. Results: The overall uptake of testing was 67% (539 of 805 patients). Low uptake rates were found for patients aged ≥80 years (33%), and patients born outside of Europe (37%). In adjusted analysis, age ≥80 years (odds ratio [OR] 0.10; P = 0.002), psychiatric disorders (OR 0.46; P = 0.006), occupation requiring at least 3 years of university or college education (OR 2.03; P = 0.003), and breast cancer or ovarian cancer in first-degree or second-degree relatives (OR 1.66; P = 0.02) were independently associated with uptake of BRCA1/2 testing. Somatic comorbidity in patients aged <70 years was associated with lower testing uptake. Conclusion: Testing uptake varies across different subgroups according to patient-related factors that are readily available in the medical records. Knowledge about these factors enables health care professionals to identify patients who are less likely to pursue genetic testing.</p>}}, author = {{Nilsson, Martin P. and Nilsson, Erik D. and Silfverberg, Barbro and Borg, Åke and Loman, Niklas}}, issn = {{1098-3600}}, language = {{eng}}, number = {{1}}, pages = {{89--96}}, publisher = {{Nature Publishing Group}}, series = {{Genetics in Medicine}}, title = {{Written pretest information and germline BRCA1/2 pathogenic variant testing in unselected breast cancer patients : predictors of testing uptake}}, url = {{http://dx.doi.org/10.1038/s41436-018-0021-9}}, doi = {{10.1038/s41436-018-0021-9}}, volume = {{21}}, year = {{2019}}, }