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Development of carboxymethyl cellulose-chitosan hybrid micro- and macroparticles for encapsulation of probiotic bacteria

Singh, Poonam; Medronho, Bruno LU ; Miguel, Maria LU ; da Silva, G J; Alves, Luis and Lindman, Björn LU (2017) In Carbohydrate Polymers 175. p.87-95
Abstract
Novel carboxymethyl cellulose-chitosan (CMC-Cht) hybrid micro- and macroparticles were successfully prepared in aqueous media either by drop-wise addition or via nozzle-spray methods. The systems were either physically or chemically crosslinked using genipin as the reticulation agent. The macroparticles (ca. 2 mm) formed are found to be essentially of the core-shell type, while the microparticles (ca. 5 tim) are apparently homogeneous. The crosslinked particles are robust, thermally resistant and less sensitive to pH changes. On the other hand, the physical systems are pH sensitive presenting a remarkable swelling at pH 7.4, while little swelling is observed at pH 2.4. Furthermore, model probiotic bacteria (Lactobacillus rhamnosus GG) was... (More)
Novel carboxymethyl cellulose-chitosan (CMC-Cht) hybrid micro- and macroparticles were successfully prepared in aqueous media either by drop-wise addition or via nozzle-spray methods. The systems were either physically or chemically crosslinked using genipin as the reticulation agent. The macroparticles (ca. 2 mm) formed are found to be essentially of the core-shell type, while the microparticles (ca. 5 tim) are apparently homogeneous. The crosslinked particles are robust, thermally resistant and less sensitive to pH changes. On the other hand, the physical systems are pH sensitive presenting a remarkable swelling at pH 7.4, while little swelling is observed at pH 2.4. Furthermore, model probiotic bacteria (Lactobacillus rhamnosus GG) was for the first time successfully encapsulated in the CMC-Cht based particles with acceptable viability count. Overall, the systems developed are highly promising for probiotic encapsulation and potential delivery in the intestinal tract with the purpose of modulating gut microbiota and improving human health. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Carbohydrate Polymers
volume
175
pages
9 pages
publisher
Elsevier
external identifiers
  • scopus:85026403113
ISSN
0144-8617
DOI
10.1016/j.carbpol.2017.06.119
language
English
LU publication?
no
id
19fb4bb8-4ed5-42b2-be56-eb9e27091b84
date added to LUP
2019-01-03 20:00:02
date last changed
2019-04-23 04:44:12
@article{19fb4bb8-4ed5-42b2-be56-eb9e27091b84,
  abstract     = {Novel carboxymethyl cellulose-chitosan (CMC-Cht) hybrid micro- and macroparticles were successfully prepared in aqueous media either by drop-wise addition or via nozzle-spray methods. The systems were either physically or chemically crosslinked using genipin as the reticulation agent. The macroparticles (ca. 2 mm) formed are found to be essentially of the core-shell type, while the microparticles (ca. 5 tim) are apparently homogeneous. The crosslinked particles are robust, thermally resistant and less sensitive to pH changes. On the other hand, the physical systems are pH sensitive presenting a remarkable swelling at pH 7.4, while little swelling is observed at pH 2.4. Furthermore, model probiotic bacteria (Lactobacillus rhamnosus GG) was for the first time successfully encapsulated in the CMC-Cht based particles with acceptable viability count. Overall, the systems developed are highly promising for probiotic encapsulation and potential delivery in the intestinal tract with the purpose of modulating gut microbiota and improving human health.},
  author       = {Singh, Poonam and Medronho, Bruno and Miguel, Maria and da Silva, G J and Alves, Luis and Lindman, Björn},
  issn         = {0144-8617},
  language     = {eng},
  month        = {11},
  pages        = {87--95},
  publisher    = {Elsevier},
  series       = {Carbohydrate Polymers},
  title        = {Development of carboxymethyl cellulose-chitosan hybrid micro- and macroparticles for encapsulation of probiotic bacteria},
  url          = {http://dx.doi.org/10.1016/j.carbpol.2017.06.119},
  volume       = {175},
  year         = {2017},
}