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Quantification of pulmonary pathology in cystic fibrosis-comparison between digital chest tomosynthesis and computed tomography

Meltzer, C. ; Gilljam, M. ; Vikgren, J. ; Norrlund, R. R. ; Vult Von Steyern, K. LU ; Båth, M. and Johnsson, A. (2021) In Radiation Protection Dosimetry 195(3-4). p.434-442
Abstract

Purpose: Digital tomosynthesis (DTS) is currently undergoing validation for potential clinical implications. The aim of this study was to investigate the potential for DTS as a low-dose alternative to computed tomography (CT) in imaging of pulmonary pathology in patients with cystic fibrosis (CF). Methods: DTS and CT were performed as part of the routine triannual follow-up in 31 CF patients. Extent of disease was quantified according to modality-specific scoring systems. Statistical analysis included Spearman's rank correlation coefficient (r) and Krippendorff's alpha (α). Major findings: The median effective dose was 0.14 for DTS and 2.68 for CT. Intermodality correlation was very strong for total score and the subscores regarding... (More)

Purpose: Digital tomosynthesis (DTS) is currently undergoing validation for potential clinical implications. The aim of this study was to investigate the potential for DTS as a low-dose alternative to computed tomography (CT) in imaging of pulmonary pathology in patients with cystic fibrosis (CF). Methods: DTS and CT were performed as part of the routine triannual follow-up in 31 CF patients. Extent of disease was quantified according to modality-specific scoring systems. Statistical analysis included Spearman's rank correlation coefficient (r) and Krippendorff's alpha (α). Major findings: The median effective dose was 0.14 for DTS and 2.68 for CT. Intermodality correlation was very strong for total score and the subscores regarding bronchiectasis and bronchial wall-thickening (r = 0.82-0.91, P < 0.01). Interobserver reliability was high for total score, bronchiectasis and mucus plugging (α = 0.83-0.93) in DTS. Conclusion: Chest tomosynthesis could be a low-dose alternative to CT in quantitative estimation of structural lung disease in CF.

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author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Radiation Protection Dosimetry
volume
195
issue
3-4
pages
9 pages
publisher
Oxford University Press
external identifiers
  • scopus:85118597847
  • pmid:33683309
ISSN
0144-8420
DOI
10.1093/rpd/ncab017
language
English
LU publication?
no
additional info
Publisher Copyright: © 2021 The Author(s) 2021 Published by Oxford University Press.
id
19ff6e42-55f8-4989-a85c-4ffc2512442f
date added to LUP
2021-11-26 14:37:02
date last changed
2024-06-15 21:40:20
@article{19ff6e42-55f8-4989-a85c-4ffc2512442f,
  abstract     = {{<p>Purpose: Digital tomosynthesis (DTS) is currently undergoing validation for potential clinical implications. The aim of this study was to investigate the potential for DTS as a low-dose alternative to computed tomography (CT) in imaging of pulmonary pathology in patients with cystic fibrosis (CF). Methods: DTS and CT were performed as part of the routine triannual follow-up in 31 CF patients. Extent of disease was quantified according to modality-specific scoring systems. Statistical analysis included Spearman's rank correlation coefficient (r) and Krippendorff's alpha (α). Major findings: The median effective dose was 0.14 for DTS and 2.68 for CT. Intermodality correlation was very strong for total score and the subscores regarding bronchiectasis and bronchial wall-thickening (r = 0.82-0.91, P &lt; 0.01). Interobserver reliability was high for total score, bronchiectasis and mucus plugging (α = 0.83-0.93) in DTS. Conclusion: Chest tomosynthesis could be a low-dose alternative to CT in quantitative estimation of structural lung disease in CF.</p>}},
  author       = {{Meltzer, C. and Gilljam, M. and Vikgren, J. and Norrlund, R. R. and Vult Von Steyern, K. and Båth, M. and Johnsson, A.}},
  issn         = {{0144-8420}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{3-4}},
  pages        = {{434--442}},
  publisher    = {{Oxford University Press}},
  series       = {{Radiation Protection Dosimetry}},
  title        = {{Quantification of pulmonary pathology in cystic fibrosis-comparison between digital chest tomosynthesis and computed tomography}},
  url          = {{http://dx.doi.org/10.1093/rpd/ncab017}},
  doi          = {{10.1093/rpd/ncab017}},
  volume       = {{195}},
  year         = {{2021}},
}