Quantification of pulmonary pathology in cystic fibrosis-comparison between digital chest tomosynthesis and computed tomography
(2021) In Radiation Protection Dosimetry 195(3-4). p.434-442- Abstract
Purpose: Digital tomosynthesis (DTS) is currently undergoing validation for potential clinical implications. The aim of this study was to investigate the potential for DTS as a low-dose alternative to computed tomography (CT) in imaging of pulmonary pathology in patients with cystic fibrosis (CF). Methods: DTS and CT were performed as part of the routine triannual follow-up in 31 CF patients. Extent of disease was quantified according to modality-specific scoring systems. Statistical analysis included Spearman's rank correlation coefficient (r) and Krippendorff's alpha (α). Major findings: The median effective dose was 0.14 for DTS and 2.68 for CT. Intermodality correlation was very strong for total score and the subscores regarding... (More)
Purpose: Digital tomosynthesis (DTS) is currently undergoing validation for potential clinical implications. The aim of this study was to investigate the potential for DTS as a low-dose alternative to computed tomography (CT) in imaging of pulmonary pathology in patients with cystic fibrosis (CF). Methods: DTS and CT were performed as part of the routine triannual follow-up in 31 CF patients. Extent of disease was quantified according to modality-specific scoring systems. Statistical analysis included Spearman's rank correlation coefficient (r) and Krippendorff's alpha (α). Major findings: The median effective dose was 0.14 for DTS and 2.68 for CT. Intermodality correlation was very strong for total score and the subscores regarding bronchiectasis and bronchial wall-thickening (r = 0.82-0.91, P < 0.01). Interobserver reliability was high for total score, bronchiectasis and mucus plugging (α = 0.83-0.93) in DTS. Conclusion: Chest tomosynthesis could be a low-dose alternative to CT in quantitative estimation of structural lung disease in CF.
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- author
- Meltzer, C. ; Gilljam, M. ; Vikgren, J. ; Norrlund, R. R. ; Vult Von Steyern, K. LU ; Båth, M. and Johnsson, A.
- publishing date
- 2021-10-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Radiation Protection Dosimetry
- volume
- 195
- issue
- 3-4
- pages
- 9 pages
- publisher
- Oxford University Press
- external identifiers
-
- pmid:33683309
- scopus:85118597847
- ISSN
- 0144-8420
- DOI
- 10.1093/rpd/ncab017
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2021 The Author(s) 2021 Published by Oxford University Press.
- id
- 19ff6e42-55f8-4989-a85c-4ffc2512442f
- date added to LUP
- 2021-11-26 14:37:02
- date last changed
- 2024-09-08 05:43:11
@article{19ff6e42-55f8-4989-a85c-4ffc2512442f, abstract = {{<p>Purpose: Digital tomosynthesis (DTS) is currently undergoing validation for potential clinical implications. The aim of this study was to investigate the potential for DTS as a low-dose alternative to computed tomography (CT) in imaging of pulmonary pathology in patients with cystic fibrosis (CF). Methods: DTS and CT were performed as part of the routine triannual follow-up in 31 CF patients. Extent of disease was quantified according to modality-specific scoring systems. Statistical analysis included Spearman's rank correlation coefficient (r) and Krippendorff's alpha (α). Major findings: The median effective dose was 0.14 for DTS and 2.68 for CT. Intermodality correlation was very strong for total score and the subscores regarding bronchiectasis and bronchial wall-thickening (r = 0.82-0.91, P < 0.01). Interobserver reliability was high for total score, bronchiectasis and mucus plugging (α = 0.83-0.93) in DTS. Conclusion: Chest tomosynthesis could be a low-dose alternative to CT in quantitative estimation of structural lung disease in CF.</p>}}, author = {{Meltzer, C. and Gilljam, M. and Vikgren, J. and Norrlund, R. R. and Vult Von Steyern, K. and Båth, M. and Johnsson, A.}}, issn = {{0144-8420}}, language = {{eng}}, month = {{10}}, number = {{3-4}}, pages = {{434--442}}, publisher = {{Oxford University Press}}, series = {{Radiation Protection Dosimetry}}, title = {{Quantification of pulmonary pathology in cystic fibrosis-comparison between digital chest tomosynthesis and computed tomography}}, url = {{http://dx.doi.org/10.1093/rpd/ncab017}}, doi = {{10.1093/rpd/ncab017}}, volume = {{195}}, year = {{2021}}, }