Molecular recognition with colloidosomes enabled by imprinted polymer nanoparticles and fluorogenic boronic acid
Shen, Xiantao LU ; Xu, Changgang LU ; Uddin, Khan Mohammed Ahsan ; Larsson, Per-Olof LU and Ye, Lei LU
(2013)
In Journal of Materials Chemistry. B
1(36).
p.4612-4618
- Abstract
- Multifunctional colloidosomes are prepared from molecularly imprinted polymer nanoparticles and fluorogenic boronic acid using a Cu(I)-catalyzed click reaction. The molecular selectivity of the colloidosomes was investigated by radioligand binding analysis, which indicated that the inter-particle click reaction did not affect the molecular specificity of the MIP nanoparticles on the colloidosomes for the model template, propranolol. Besides specific molecular recognition of the MIP nanoparticles, the colloidosomes also displayed dose-dependent fluorescence response to fructose at physiological pH. Moreover, the immobilized boronic acid in the core could effectively bind isoproterenol, a template analogue containing a catecholamine moiety.... (More)
- Multifunctional colloidosomes are prepared from molecularly imprinted polymer nanoparticles and fluorogenic boronic acid using a Cu(I)-catalyzed click reaction. The molecular selectivity of the colloidosomes was investigated by radioligand binding analysis, which indicated that the inter-particle click reaction did not affect the molecular specificity of the MIP nanoparticles on the colloidosomes for the model template, propranolol. Besides specific molecular recognition of the MIP nanoparticles, the colloidosomes also displayed dose-dependent fluorescence response to fructose at physiological pH. Moreover, the immobilized boronic acid in the core could effectively bind isoproterenol, a template analogue containing a catecholamine moiety. The depletion of isoproterenol from solution allowed the MIP nanoparticles on the colloidosomes to bind propranolol more efficiently. The pre-designed molecular selectivity and fluorescence response of the colloidosomes are interesting for potential applications in controlled delivery, chemical sensing and bioseparation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4027028
- author
- Shen, Xiantao
LU
; Xu, Changgang
LU
; Uddin, Khan Mohammed Ahsan
; Larsson, Per-Olof
LU
and Ye, Lei
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Materials Chemistry. B
- volume
- 1
- issue
- 36
- pages
- 4612 - 4618
- publisher
- Royal Society of Chemistry
- external identifiers
-
- wos:000323484100009
- scopus:84882981949
- ISSN
- 2050-7518
- DOI
- 10.1039/c3tb20860e
- language
- English
- LU publication?
- yes
- id
- 1a3ac89a-078e-41eb-bcdc-93ddb4ac8d0c (old id 4027028)
- date added to LUP
- 2016-04-01 09:51:10
- date last changed
- 2022-04-11 23:34:02
@article{1a3ac89a-078e-41eb-bcdc-93ddb4ac8d0c,
abstract = {{Multifunctional colloidosomes are prepared from molecularly imprinted polymer nanoparticles and fluorogenic boronic acid using a Cu(I)-catalyzed click reaction. The molecular selectivity of the colloidosomes was investigated by radioligand binding analysis, which indicated that the inter-particle click reaction did not affect the molecular specificity of the MIP nanoparticles on the colloidosomes for the model template, propranolol. Besides specific molecular recognition of the MIP nanoparticles, the colloidosomes also displayed dose-dependent fluorescence response to fructose at physiological pH. Moreover, the immobilized boronic acid in the core could effectively bind isoproterenol, a template analogue containing a catecholamine moiety. The depletion of isoproterenol from solution allowed the MIP nanoparticles on the colloidosomes to bind propranolol more efficiently. The pre-designed molecular selectivity and fluorescence response of the colloidosomes are interesting for potential applications in controlled delivery, chemical sensing and bioseparation.}},
author = {{Shen, Xiantao and Xu, Changgang and Uddin, Khan Mohammed Ahsan and Larsson, Per-Olof and Ye, Lei}},
issn = {{2050-7518}},
language = {{eng}},
number = {{36}},
pages = {{4612--4618}},
publisher = {{Royal Society of Chemistry}},
series = {{Journal of Materials Chemistry. B}},
title = {{Molecular recognition with colloidosomes enabled by imprinted polymer nanoparticles and fluorogenic boronic acid}},
url = {{http://dx.doi.org/10.1039/c3tb20860e}},
doi = {{10.1039/c3tb20860e}},
volume = {{1}},
year = {{2013}},
}