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Cardiovascular drug treatment, statins and biopsy-confirmed giant cell arteritis : a population-based case-control study

Turkiewicz, Aleksandra LU ; Stamatis, Pavlos LU orcid and Mohammad, Aladdin J. LU (2020) In RMD Open 6(2).
Abstract

OBJECTIVE: To determine whether exposure to cardiovascular medications and statins is associated with increased risk of giant cell arteritis (GCA). DESIGN: The population-based case-control study comprised a cohort of patients with biopsy-confirmed GCA linked to the Swedish Prescribed Drug Register to identify all exposure to drugs prior to diagnosis of GCA. Ten controls per GCA case, matched for age, sex and residential area, were included. Using corresponding Anatomical Therapeutic Chemical codes, ACE inhibitors, angiotensin II receptor blockers, beta-blocking agents, calcium antagonists, diuretics, statins and cardiac therapy drugs were investigated from July 1, 2005 to the diagnosis/index date. A conditional logistic regression... (More)

OBJECTIVE: To determine whether exposure to cardiovascular medications and statins is associated with increased risk of giant cell arteritis (GCA). DESIGN: The population-based case-control study comprised a cohort of patients with biopsy-confirmed GCA linked to the Swedish Prescribed Drug Register to identify all exposure to drugs prior to diagnosis of GCA. Ten controls per GCA case, matched for age, sex and residential area, were included. Using corresponding Anatomical Therapeutic Chemical codes, ACE inhibitors, angiotensin II receptor blockers, beta-blocking agents, calcium antagonists, diuretics, statins and cardiac therapy drugs were investigated from July 1, 2005 to the diagnosis/index date. A conditional logistic regression model was fitted adjusted for income, education level and marital status. We repeated the analyses including only new drug users excluding those with any prescription during the year from July 1, 2005 to July 1, 2006. RESULTS: 574 cases (29% men) of diagnosed GCA and 5740 controls (29% men) were included. The mean age at diagnosis is 75 years (SD 8). Of the GCA cases, 71% had at least one dispensation of a cardiovascular drug prior to the index date, compared to 74% of controls. The ORs for the association of target drug exposure with GCA were <1 for most drugs, but close to 1 in the analysis of new users. Statins were consistently associated with lower risk of GCA, OR 0.74 (95% CI 0.61 to 0.90). CONCLUSION: Statins may be associated with lower risk of incident biopsy-confirmed GCA. No association was evident for other studied drugs.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiovascular Diseases, Epidemiology, Giant Cell Arteritis
in
RMD Open
volume
6
issue
2
article number
e001285
publisher
BMJ Publishing Group
external identifiers
  • scopus:85089463582
  • pmid:32792416
ISSN
2056-5933
DOI
10.1136/rmdopen-2020-001285
language
English
LU publication?
yes
id
1a5d0dc3-ef51-4435-a5e0-77d8de12cce4
date added to LUP
2020-08-27 13:29:46
date last changed
2024-05-15 18:07:53
@article{1a5d0dc3-ef51-4435-a5e0-77d8de12cce4,
  abstract     = {{<p>OBJECTIVE: To determine whether exposure to cardiovascular medications and statins is associated with increased risk of giant cell arteritis (GCA). DESIGN: The population-based case-control study comprised a cohort of patients with biopsy-confirmed GCA linked to the Swedish Prescribed Drug Register to identify all exposure to drugs prior to diagnosis of GCA. Ten controls per GCA case, matched for age, sex and residential area, were included. Using corresponding Anatomical Therapeutic Chemical codes, ACE inhibitors, angiotensin II receptor blockers, beta-blocking agents, calcium antagonists, diuretics, statins and cardiac therapy drugs were investigated from July 1, 2005 to the diagnosis/index date. A conditional logistic regression model was fitted adjusted for income, education level and marital status. We repeated the analyses including only new drug users excluding those with any prescription during the year from July 1, 2005 to July 1, 2006. RESULTS: 574 cases (29% men) of diagnosed GCA and 5740 controls (29% men) were included. The mean age at diagnosis is 75 years (SD 8). Of the GCA cases, 71% had at least one dispensation of a cardiovascular drug prior to the index date, compared to 74% of controls. The ORs for the association of target drug exposure with GCA were &lt;1 for most drugs, but close to 1 in the analysis of new users. Statins were consistently associated with lower risk of GCA, OR 0.74 (95% CI 0.61 to 0.90). CONCLUSION: Statins may be associated with lower risk of incident biopsy-confirmed GCA. No association was evident for other studied drugs.</p>}},
  author       = {{Turkiewicz, Aleksandra and Stamatis, Pavlos and Mohammad, Aladdin J.}},
  issn         = {{2056-5933}},
  keywords     = {{Cardiovascular Diseases; Epidemiology; Giant Cell Arteritis}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{RMD Open}},
  title        = {{Cardiovascular drug treatment, statins and biopsy-confirmed giant cell arteritis : a population-based case-control study}},
  url          = {{http://dx.doi.org/10.1136/rmdopen-2020-001285}},
  doi          = {{10.1136/rmdopen-2020-001285}},
  volume       = {{6}},
  year         = {{2020}},
}