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Characterization of the bone-metal implant interface by Digital Volume Correlation of in-situ loading using neutron tomography

Le Cann, Sophie LU ; Tudisco, Erika LU ; Perdikouri, Christina LU ; Belfrage, Ola LU ; Kaestner, Anders; Hall, Stephen LU ; Tägil, Magnus LU and Isaksson, Hanna LU (2017) In Journal of the Mechanical Behavior of Biomedical Materials 75. p.271-278
Abstract

Metallic implants are commonly used as surgical treatments for many orthopedic conditions. The long-term stability of implants relies on an adequate integration with the surrounding bone. Unsuccessful integration could lead to implant loosening. By combining mechanical loading with high-resolution 3D imaging methods, followed by image analysis such as Digital Volume Correlation (DVC), we aim at evaluating ex vivo the mechanical resistance of newly formed bone at the interface. X-rays tomography is commonly used to image bone but induces artefacts close to metallic components. Utilizing a different interaction with matter, neutron tomography is a promising alternative but has not yet been used in studies of bone mechanics. This work... (More)

Metallic implants are commonly used as surgical treatments for many orthopedic conditions. The long-term stability of implants relies on an adequate integration with the surrounding bone. Unsuccessful integration could lead to implant loosening. By combining mechanical loading with high-resolution 3D imaging methods, followed by image analysis such as Digital Volume Correlation (DVC), we aim at evaluating ex vivo the mechanical resistance of newly formed bone at the interface. X-rays tomography is commonly used to image bone but induces artefacts close to metallic components. Utilizing a different interaction with matter, neutron tomography is a promising alternative but has not yet been used in studies of bone mechanics. This work demonstrates that neutron tomography during in situ loading is a feasible tool to characterize the mechanical response of bone-implant interfaces, especially when combined with DVC. Experiments were performed where metal screws were implanted in rat tibiae during 4 weeks. The screws were pulled-out while the samples were sequentially imaged in situ with neutron tomography. The images were analyzed to quantify bone ingrowth around the implants. DVC was used to track the internal displacements and calculate the strain fields in the bone during loading. The neutron images were free of metal-related artefacts, which enabled accurate quantification of bone ingrowth on the screw (ranging from 60% to 71%). DVC allowed successful identification of the deformation and cracks that occurred during mechanical loading and led to final failure of the bone-implant interface.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bone, Digital Volume Correlation, Metallic screw, Neutron tomography
in
Journal of the Mechanical Behavior of Biomedical Materials
volume
75
pages
8 pages
publisher
Elsevier
external identifiers
  • scopus:85026419043
  • wos:000412959000032
ISSN
1751-6161
DOI
10.1016/j.jmbbm.2017.07.001
language
English
LU publication?
yes
id
1a66323d-62a9-4155-95a9-e6a82378b58c
date added to LUP
2017-08-25 10:54:30
date last changed
2018-01-16 13:23:31
@article{1a66323d-62a9-4155-95a9-e6a82378b58c,
  abstract     = {<p>Metallic implants are commonly used as surgical treatments for many orthopedic conditions. The long-term stability of implants relies on an adequate integration with the surrounding bone. Unsuccessful integration could lead to implant loosening. By combining mechanical loading with high-resolution 3D imaging methods, followed by image analysis such as Digital Volume Correlation (DVC), we aim at evaluating ex vivo the mechanical resistance of newly formed bone at the interface. X-rays tomography is commonly used to image bone but induces artefacts close to metallic components. Utilizing a different interaction with matter, neutron tomography is a promising alternative but has not yet been used in studies of bone mechanics. This work demonstrates that neutron tomography during in situ loading is a feasible tool to characterize the mechanical response of bone-implant interfaces, especially when combined with DVC. Experiments were performed where metal screws were implanted in rat tibiae during 4 weeks. The screws were pulled-out while the samples were sequentially imaged in situ with neutron tomography. The images were analyzed to quantify bone ingrowth around the implants. DVC was used to track the internal displacements and calculate the strain fields in the bone during loading. The neutron images were free of metal-related artefacts, which enabled accurate quantification of bone ingrowth on the screw (ranging from 60% to 71%). DVC allowed successful identification of the deformation and cracks that occurred during mechanical loading and led to final failure of the bone-implant interface.</p>},
  author       = {Le Cann, Sophie and Tudisco, Erika and Perdikouri, Christina and Belfrage, Ola and Kaestner, Anders and Hall, Stephen and Tägil, Magnus and Isaksson, Hanna},
  issn         = {1751-6161},
  keyword      = {Bone,Digital Volume Correlation,Metallic screw,Neutron tomography},
  language     = {eng},
  month        = {11},
  pages        = {271--278},
  publisher    = {Elsevier},
  series       = {Journal of the Mechanical Behavior of Biomedical Materials},
  title        = {Characterization of the bone-metal implant interface by Digital Volume Correlation of in-situ loading using neutron tomography},
  url          = {http://dx.doi.org/10.1016/j.jmbbm.2017.07.001},
  volume       = {75},
  year         = {2017},
}