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Metabolic disturbances in diseases with neurological involvement

Duarte, João M N LU ; Schuck, Patrícia F; Wenk, Gary L and Ferreira, Gustavo C (2014) In Aging and Disease 5(4). p.55-238
Abstract

Degeneration of specific neuronal populations and progressive nervous system dysfunction characterize neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These findings are also reported in inherited diseases such as phenylketonuria and glutaric aciduria type I. The involvement of mitochondrial dysfunction in these diseases was reported, elicited by genetic alterations, exogenous toxins or buildup of toxic metabolites. In this review we shall discuss some metabolic alterations related to the pathophysiology of diseases with neurological involvement and aging process. These findings may help identifying early disease biomarkers and lead to more effective therapies to improve the quality of life of the... (More)

Degeneration of specific neuronal populations and progressive nervous system dysfunction characterize neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These findings are also reported in inherited diseases such as phenylketonuria and glutaric aciduria type I. The involvement of mitochondrial dysfunction in these diseases was reported, elicited by genetic alterations, exogenous toxins or buildup of toxic metabolites. In this review we shall discuss some metabolic alterations related to the pathophysiology of diseases with neurological involvement and aging process. These findings may help identifying early disease biomarkers and lead to more effective therapies to improve the quality of life of the patients affected by these devastating illnesses.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Journal Article, Review
in
Aging and Disease
volume
5
issue
4
pages
18 pages
publisher
INT SOC AGING & DISEASE
external identifiers
  • scopus:84916931763
ISSN
2152-5250
DOI
10.14336/AD.2014.0500238
language
English
LU publication?
no
id
1a9232c2-1eb6-4123-b605-949167ff5c5e
date added to LUP
2017-10-19 15:23:26
date last changed
2017-10-30 13:58:29
@article{1a9232c2-1eb6-4123-b605-949167ff5c5e,
  abstract     = {<p>Degeneration of specific neuronal populations and progressive nervous system dysfunction characterize neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These findings are also reported in inherited diseases such as phenylketonuria and glutaric aciduria type I. The involvement of mitochondrial dysfunction in these diseases was reported, elicited by genetic alterations, exogenous toxins or buildup of toxic metabolites. In this review we shall discuss some metabolic alterations related to the pathophysiology of diseases with neurological involvement and aging process. These findings may help identifying early disease biomarkers and lead to more effective therapies to improve the quality of life of the patients affected by these devastating illnesses.</p>},
  author       = {Duarte, João M N and Schuck, Patrícia F and Wenk, Gary L and Ferreira, Gustavo C},
  issn         = {2152-5250},
  keyword      = {Journal Article,Review},
  language     = {eng},
  number       = {4},
  pages        = {55--238},
  publisher    = {INT SOC AGING & DISEASE},
  series       = {Aging and Disease},
  title        = {Metabolic disturbances in diseases with neurological involvement},
  url          = {http://dx.doi.org/10.14336/AD.2014.0500238},
  volume       = {5},
  year         = {2014},
}