Metabolic disturbances in diseases with neurological involvement
Duarte, João M N LU
; Schuck, Patrícia F
; Wenk, Gary L
and Ferreira, Gustavo C
(2014)
In Aging and Disease
5(4).
p.55-238
- Abstract
Degeneration of specific neuronal populations and progressive nervous system dysfunction characterize neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These findings are also reported in inherited diseases such as phenylketonuria and glutaric aciduria type I. The involvement of mitochondrial dysfunction in these diseases was reported, elicited by genetic alterations, exogenous toxins or buildup of toxic metabolites. In this review we shall discuss some metabolic alterations related to the pathophysiology of diseases with neurological involvement and aging process. These findings may help identifying early disease biomarkers and lead to more effective therapies to improve the quality of life of the... (More)
Degeneration of specific neuronal populations and progressive nervous system dysfunction characterize neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These findings are also reported in inherited diseases such as phenylketonuria and glutaric aciduria type I. The involvement of mitochondrial dysfunction in these diseases was reported, elicited by genetic alterations, exogenous toxins or buildup of toxic metabolites. In this review we shall discuss some metabolic alterations related to the pathophysiology of diseases with neurological involvement and aging process. These findings may help identifying early disease biomarkers and lead to more effective therapies to improve the quality of life of the patients affected by these devastating illnesses.
(Less)
- author
- Duarte, João M N
LU
; Schuck, Patrícia F
; Wenk, Gary L
and Ferreira, Gustavo C
- publishing date
- 2014-08
- type
- Contribution to journal
- publication status
- published
- keywords
- Journal Article, Review
- in
- Aging and Disease
- volume
- 5
- issue
- 4
- pages
- 18 pages
- publisher
- Buck Institute for Age Research
- external identifiers
-
- pmid:25110608
- scopus:84916931763
- ISSN
- 2152-5250
- DOI
- 10.14336/AD.2014.0500238
- language
- English
- LU publication?
- no
- id
- 1a9232c2-1eb6-4123-b605-949167ff5c5e
- date added to LUP
- 2017-10-19 15:23:26
- date last changed
- 2024-03-31 19:03:42
@article{1a9232c2-1eb6-4123-b605-949167ff5c5e,
abstract = {{<p>Degeneration of specific neuronal populations and progressive nervous system dysfunction characterize neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These findings are also reported in inherited diseases such as phenylketonuria and glutaric aciduria type I. The involvement of mitochondrial dysfunction in these diseases was reported, elicited by genetic alterations, exogenous toxins or buildup of toxic metabolites. In this review we shall discuss some metabolic alterations related to the pathophysiology of diseases with neurological involvement and aging process. These findings may help identifying early disease biomarkers and lead to more effective therapies to improve the quality of life of the patients affected by these devastating illnesses.</p>}},
author = {{Duarte, João M N and Schuck, Patrícia F and Wenk, Gary L and Ferreira, Gustavo C}},
issn = {{2152-5250}},
keywords = {{Journal Article; Review}},
language = {{eng}},
number = {{4}},
pages = {{55--238}},
publisher = {{Buck Institute for Age Research}},
series = {{Aging and Disease}},
title = {{Metabolic disturbances in diseases with neurological involvement}},
url = {{http://dx.doi.org/10.14336/AD.2014.0500238}},
doi = {{10.14336/AD.2014.0500238}},
volume = {{5}},
year = {{2014}},
}