Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Isolation of two tissue-specific Drosophila paired box genes, Pox meso and Pox neuro

Bopp, D. ; Jamet, E. ; Baumgartner, S. LU orcid ; Burri, M. and Noll, M. (1989) In EMBO Journal 8(11). p.3447-3457
Abstract

Two new paired domain genes of Drosophila, Pox meso and Pox neuro, are described. In contrast to the previously isolated paired domain gnees, paired and gooseberry, which contain both a paired and a homeodomain (PHox genes), Pox meso and Pox neuro possess no homeodomain. Evidence suggesting that the new genes encode tissue-specific transcriptional factors and belong to the same regulatory cascade as the other paired domain genes includes (i) tissue-specific expression of Pox meso in the somatic mesoderm and of Pox neuro in the central and peripheral nervous system, (ii) nuclear localization of their proteins, (iiI) dependence on prd activity and (iv) presence of the paired domain in genes of known regulatory activity. While no mutant... (More)

Two new paired domain genes of Drosophila, Pox meso and Pox neuro, are described. In contrast to the previously isolated paired domain gnees, paired and gooseberry, which contain both a paired and a homeodomain (PHox genes), Pox meso and Pox neuro possess no homeodomain. Evidence suggesting that the new genes encode tissue-specific transcriptional factors and belong to the same regulatory cascade as the other paired domain genes includes (i) tissue-specific expression of Pox meso in the somatic mesoderm and of Pox neuro in the central and peripheral nervous system, (ii) nuclear localization of their proteins, (iiI) dependence on prd activity and (iv) presence of the paired domain in genes of known regulatory activity. While no mutant phenotypes of Pox meso and Pox neuro have yet been discovered, a murine gene with a paired domain closely homologous to that of Pox meso has recently been identified with the undulated mutant. Both Pox meso and undulated are expressed in tissues derived from the somatic mesoderm. The five known Drosophila paired domains fall into three classes: (i) the prd,gsb-class, (ii) the Pox meso, undulated-class and (iii) the Pox neuro-class which probably includes the paired domain of the murine gene Pax 2.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
EMBO Journal
volume
8
issue
11
pages
3447 - 3457
publisher
Oxford University Press
external identifiers
  • scopus:0024424064
  • pmid:2573516
ISSN
0261-4189
DOI
10.1002/j.1460-2075.1989.tb08509.x
language
English
LU publication?
no
id
1aa9df9f-6c93-448b-95e8-7ce87bf93b3e
date added to LUP
2019-05-21 14:10:57
date last changed
2024-02-15 06:53:55
@article{1aa9df9f-6c93-448b-95e8-7ce87bf93b3e,
  abstract     = {{<p>Two new paired domain genes of Drosophila, Pox meso and Pox neuro, are described. In contrast to the previously isolated paired domain gnees, paired and gooseberry, which contain both a paired and a homeodomain (PHox genes), Pox meso and Pox neuro possess no homeodomain. Evidence suggesting that the new genes encode tissue-specific transcriptional factors and belong to the same regulatory cascade as the other paired domain genes includes (i) tissue-specific expression of Pox meso in the somatic mesoderm and of Pox neuro in the central and peripheral nervous system, (ii) nuclear localization of their proteins, (iiI) dependence on prd activity and (iv) presence of the paired domain in genes of known regulatory activity. While no mutant phenotypes of Pox meso and Pox neuro have yet been discovered, a murine gene with a paired domain closely homologous to that of Pox meso has recently been identified with the undulated mutant. Both Pox meso and undulated are expressed in tissues derived from the somatic mesoderm. The five known Drosophila paired domains fall into three classes: (i) the prd,gsb-class, (ii) the Pox meso, undulated-class and (iii) the Pox neuro-class which probably includes the paired domain of the murine gene Pax 2.</p>}},
  author       = {{Bopp, D. and Jamet, E. and Baumgartner, S. and Burri, M. and Noll, M.}},
  issn         = {{0261-4189}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{11}},
  pages        = {{3447--3457}},
  publisher    = {{Oxford University Press}},
  series       = {{EMBO Journal}},
  title        = {{Isolation of two tissue-specific Drosophila paired box genes, Pox meso and Pox neuro}},
  url          = {{http://dx.doi.org/10.1002/j.1460-2075.1989.tb08509.x}},
  doi          = {{10.1002/j.1460-2075.1989.tb08509.x}},
  volume       = {{8}},
  year         = {{1989}},
}