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Cardiovascular disease risk in early rheumatoid arthritis : the impact of cartilage oligomeric matrix protein (COMP) and disease activity

Rydell, Emil LU orcid ; Jacobsson, Lennart Th LU ; Saxne, Tore LU and Turesson, Carl LU (2023) In BMC Rheumatology 7(1).
Abstract

Background: To investigate whether baseline serum cartilage oligomeric matrix protein (COMP), patient characteristics, traditional cardiovascular disease (CVD) risk factors and disease activity over time predict CVD, in early rheumatoid arthritis (RA). Methods: This study included patients with early RA (< 12 months disease duration) (n = 233) recruited 1995–2005. Potential predictors of CVD and coronary artery disease (CAD) were assessed using Cox regression. Results: A first ever diagnosis of CVD occurred in 70 patients, and CAD in 52. Age, sex, hypertension and diabetes predicted CVD and CAD. COMP was associated with increased risk of CVD and CAD [crude hazard ratios (HRs) per SD 1.45; 95% CI 1.17–1.80 and 1.51; 95% CI 1.18–1.92,... (More)

Background: To investigate whether baseline serum cartilage oligomeric matrix protein (COMP), patient characteristics, traditional cardiovascular disease (CVD) risk factors and disease activity over time predict CVD, in early rheumatoid arthritis (RA). Methods: This study included patients with early RA (< 12 months disease duration) (n = 233) recruited 1995–2005. Potential predictors of CVD and coronary artery disease (CAD) were assessed using Cox regression. Results: A first ever diagnosis of CVD occurred in 70 patients, and CAD in 52. Age, sex, hypertension and diabetes predicted CVD and CAD. COMP was associated with increased risk of CVD and CAD [crude hazard ratios (HRs) per SD 1.45; 95% CI 1.17–1.80 and 1.51; 95% CI 1.18–1.92, respectively]. When adjusted for age, sex, hypertension, diabetes and ESR, results where similar but did not reach significance [HRs 1.32, 95% CI 0.99–1.74 and 1.35, 95% CI 0.99–1.86]. Baseline disease activity did not independently predict CVD. High DAS28 (> 5.1) at two years was associated with increased risk of subsequent CVD [adjusted HR 2.58; 95% CI 1.10–6.04] and CAD. ESR and CRP at two years as well as cumulative disease activity over 2 years independently predicted CVD and CAD. Conclusion: COMP may be a novel predictor of CVD and CAD in RA. Active disease two years after RA diagnosis, as well as cumulative disease activity, was associated with increased risk of CVD and CAD, independent of traditional CVD risk factors. Awareness of the particularly increased CVD risk among difficult to treat patients is important in order to further reduce CVD in RA.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Arthritis, rheumatoid, Biomarkers, Cardiovascular Diseases, Prognosis
in
BMC Rheumatology
volume
7
issue
1
article number
43
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85178200353
  • pmid:38037148
ISSN
2520-1026
DOI
10.1186/s41927-023-00367-2
language
English
LU publication?
yes
id
1aac8e51-2de3-4f33-bb19-5cc5070aed00
date added to LUP
2023-12-18 15:27:52
date last changed
2025-06-26 21:26:33
@article{1aac8e51-2de3-4f33-bb19-5cc5070aed00,
  abstract     = {{<p>Background: To investigate whether baseline serum cartilage oligomeric matrix protein (COMP), patient characteristics, traditional cardiovascular disease (CVD) risk factors and disease activity over time predict CVD, in early rheumatoid arthritis (RA). Methods: This study included patients with early RA (&lt; 12 months disease duration) (n = 233) recruited 1995–2005. Potential predictors of CVD and coronary artery disease (CAD) were assessed using Cox regression. Results: A first ever diagnosis of CVD occurred in 70 patients, and CAD in 52. Age, sex, hypertension and diabetes predicted CVD and CAD. COMP was associated with increased risk of CVD and CAD [crude hazard ratios (HRs) per SD 1.45; 95% CI 1.17–1.80 and 1.51; 95% CI 1.18–1.92, respectively]. When adjusted for age, sex, hypertension, diabetes and ESR, results where similar but did not reach significance [HRs 1.32, 95% CI 0.99–1.74 and 1.35, 95% CI 0.99–1.86]. Baseline disease activity did not independently predict CVD. High DAS28 (&gt; 5.1) at two years was associated with increased risk of subsequent CVD [adjusted HR 2.58; 95% CI 1.10–6.04] and CAD. ESR and CRP at two years as well as cumulative disease activity over 2 years independently predicted CVD and CAD. Conclusion: COMP may be a novel predictor of CVD and CAD in RA. Active disease two years after RA diagnosis, as well as cumulative disease activity, was associated with increased risk of CVD and CAD, independent of traditional CVD risk factors. Awareness of the particularly increased CVD risk among difficult to treat patients is important in order to further reduce CVD in RA.</p>}},
  author       = {{Rydell, Emil and Jacobsson, Lennart Th and Saxne, Tore and Turesson, Carl}},
  issn         = {{2520-1026}},
  keywords     = {{Arthritis, rheumatoid; Biomarkers; Cardiovascular Diseases; Prognosis}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Rheumatology}},
  title        = {{Cardiovascular disease risk in early rheumatoid arthritis : the impact of cartilage oligomeric matrix protein (COMP) and disease activity}},
  url          = {{http://dx.doi.org/10.1186/s41927-023-00367-2}},
  doi          = {{10.1186/s41927-023-00367-2}},
  volume       = {{7}},
  year         = {{2023}},
}