A Novel Microparticle Based Formulation for Topical Delivery of FOL-005, a Small Peptide
(2022) In Journal of Pharmaceutical Sciences 111(5). p.1309-1317- Abstract
Although many therapeutically active peptides and proteins have been developed there is a lack of topical pharmaceutical products on the market containing these sensitive molecules. The main reasons may be lack of stability and a limitation of larger molecules to penetrate into the skin. In this study we investigated the possibility to develop a peptide formulation which enables follicular permeation of peptides and passes the following criteria: 1) The formulation should be chemically and physically stable, 2) The formulation should have appealing cosmetical properties and 3) The formulation should be compatible with skin as well as sebum. The hypothesis was that increased stability of the peptide could be obtained by keeping the... (More)
Although many therapeutically active peptides and proteins have been developed there is a lack of topical pharmaceutical products on the market containing these sensitive molecules. The main reasons may be lack of stability and a limitation of larger molecules to penetrate into the skin. In this study we investigated the possibility to develop a peptide formulation which enables follicular permeation of peptides and passes the following criteria: 1) The formulation should be chemically and physically stable, 2) The formulation should have appealing cosmetical properties and 3) The formulation should be compatible with skin as well as sebum. The hypothesis was that increased stability of the peptide could be obtained by keeping the peptide in solid form and in a water-free environment, and that permeation into skin could be facilitated by reducing the particle size to < 10 µm and by formulating the peptide in sebum compatible excipients. By this method a safe and a cosmetically attractive formulation, facilitating the local distribution of the model peptide FOL-005 into the skin and at the same time securing chemical and physical stability, was successfully developed.
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- author
- Runnsjö, Anna ; Liljedahl, Susanna ; Sagna, David ; Ekblad, Maria and Alenfall, Jan LU
- organization
- publishing date
- 2022-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cosmetical evaluation, Follicle, Formulation, Hair, Hair follicle delivery, Microparticle, Peptide, Skin, Topical
- in
- Journal of Pharmaceutical Sciences
- volume
- 111
- issue
- 5
- pages
- 9 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85124390511
- pmid:35093338
- ISSN
- 0022-3549
- DOI
- 10.1016/j.xphs.2022.01.009
- language
- English
- LU publication?
- yes
- id
- 1ad13ffa-e7f1-450f-95e0-cac5dcb99e2d
- date added to LUP
- 2022-12-28 11:22:16
- date last changed
- 2024-05-30 21:27:52
@article{1ad13ffa-e7f1-450f-95e0-cac5dcb99e2d,
abstract = {{<p>Although many therapeutically active peptides and proteins have been developed there is a lack of topical pharmaceutical products on the market containing these sensitive molecules. The main reasons may be lack of stability and a limitation of larger molecules to penetrate into the skin. In this study we investigated the possibility to develop a peptide formulation which enables follicular permeation of peptides and passes the following criteria: 1) The formulation should be chemically and physically stable, 2) The formulation should have appealing cosmetical properties and 3) The formulation should be compatible with skin as well as sebum. The hypothesis was that increased stability of the peptide could be obtained by keeping the peptide in solid form and in a water-free environment, and that permeation into skin could be facilitated by reducing the particle size to < 10 µm and by formulating the peptide in sebum compatible excipients. By this method a safe and a cosmetically attractive formulation, facilitating the local distribution of the model peptide FOL-005 into the skin and at the same time securing chemical and physical stability, was successfully developed.</p>}},
author = {{Runnsjö, Anna and Liljedahl, Susanna and Sagna, David and Ekblad, Maria and Alenfall, Jan}},
issn = {{0022-3549}},
keywords = {{Cosmetical evaluation; Follicle; Formulation; Hair; Hair follicle delivery; Microparticle; Peptide; Skin; Topical}},
language = {{eng}},
number = {{5}},
pages = {{1309--1317}},
publisher = {{Elsevier}},
series = {{Journal of Pharmaceutical Sciences}},
title = {{A Novel Microparticle Based Formulation for Topical Delivery of FOL-005, a Small Peptide}},
url = {{http://dx.doi.org/10.1016/j.xphs.2022.01.009}},
doi = {{10.1016/j.xphs.2022.01.009}},
volume = {{111}},
year = {{2022}},
}