A click approach to unprotected glycodendrimers
(2006) In Macromolecules 39(6). p.2113-2120- Abstract
Click chemistry in combination with ultrafiltration has allowed the quick, efficient, and reliable multivalent conjugation of unprotected alkyne-derived carbohydrates to three generations of azido-terminated gallic acid-triethylene glycol dendrimers under aqueous conditions. The reported procedure allows the atom economical incorporation of up to 27 unprotected fucose, mannose, and lactose residues, in reproducible high yields (up to 92%), requiring only catalytic amounts of Cu. The completion of the conjugation process was clearly established in all cases by both 1H NMR and MALDI-TOF MS.
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https://lup.lub.lu.se/record/1ad86531-8b41-423e-8e96-d10fe9f8bc30
- author
- Fernandez-Megia, Eduardo ; Correa, Juan ; Rodríguez-Meizoso, Irene LU and Riguera, Ricardo
- publishing date
- 2006-03-21
- type
- Contribution to journal
- publication status
- published
- in
- Macromolecules
- volume
- 39
- issue
- 6
- pages
- 8 pages
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- scopus:33645814833
- ISSN
- 0024-9297
- DOI
- 10.1021/ma052448w
- language
- English
- LU publication?
- no
- id
- 1ad86531-8b41-423e-8e96-d10fe9f8bc30
- date added to LUP
- 2017-04-10 10:43:59
- date last changed
- 2022-04-01 07:57:36
@article{1ad86531-8b41-423e-8e96-d10fe9f8bc30, abstract = {{<p>Click chemistry in combination with ultrafiltration has allowed the quick, efficient, and reliable multivalent conjugation of unprotected alkyne-derived carbohydrates to three generations of azido-terminated gallic acid-triethylene glycol dendrimers under aqueous conditions. The reported procedure allows the atom economical incorporation of up to 27 unprotected fucose, mannose, and lactose residues, in reproducible high yields (up to 92%), requiring only catalytic amounts of Cu. The completion of the conjugation process was clearly established in all cases by both <sup>1</sup>H NMR and MALDI-TOF MS.</p>}}, author = {{Fernandez-Megia, Eduardo and Correa, Juan and Rodríguez-Meizoso, Irene and Riguera, Ricardo}}, issn = {{0024-9297}}, language = {{eng}}, month = {{03}}, number = {{6}}, pages = {{2113--2120}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Macromolecules}}, title = {{A click approach to unprotected glycodendrimers}}, url = {{http://dx.doi.org/10.1021/ma052448w}}, doi = {{10.1021/ma052448w}}, volume = {{39}}, year = {{2006}}, }