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Human immunoglobulin constant heavy G chain (IGHG) (Fcγ) (GM) genes, defining innate variants of IgG molecules and B cells, have impact on disease and therapy.

Oxelius, Vivi-Anne LU and Pandey, Janardan P (2013) In Clinical Immunology 149(3). p.475-486
Abstract
The distinguished alternative GM allotypes localized in immunoglobulin constant heavy G chain IGHG (Fcγ) (GM) genes on chromosome 14q32.3 define two unique variants of respectively IgG3, IgG1 and IgG2 subclasses, with different structures and functions. The IGHG allele (allotypes), expressed in homozygous or heterozygous forms, are assessed by new serological methods. Fixed combinations of γ3, γ1 and γ2 allotypes constitute the haplotypes, which are indirect markers of B cells. We highlight the role of homozygous IGHG genes with restricted qualities of IgG subclass molecules and B cells. These common Mendelian IGHG genes respond differently to allergens and infections, both bacterial and viral, and to active and passive immunotherapies.... (More)
The distinguished alternative GM allotypes localized in immunoglobulin constant heavy G chain IGHG (Fcγ) (GM) genes on chromosome 14q32.3 define two unique variants of respectively IgG3, IgG1 and IgG2 subclasses, with different structures and functions. The IGHG allele (allotypes), expressed in homozygous or heterozygous forms, are assessed by new serological methods. Fixed combinations of γ3, γ1 and γ2 allotypes constitute the haplotypes, which are indirect markers of B cells. We highlight the role of homozygous IGHG genes with restricted qualities of IgG subclass molecules and B cells. These common Mendelian IGHG genes respond differently to allergens and infections, both bacterial and viral, and to active and passive immunotherapies. IGHG genes have an impact on diseases such as allergy, immunodeficiency, autoimmunity and malignancy. Association/linkage of different IGHG genes gives information about risk/protection, good or bad prognosis, for improvement of clinical care. The IGHG gene map of healthy Caucasians is registered. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Immunology
volume
149
issue
3
pages
475 - 486
publisher
Elsevier
external identifiers
  • wos:000328874800013
  • pmid:24239836
  • scopus:84887564125
  • pmid:24239836
ISSN
1521-6616
DOI
10.1016/j.clim.2013.10.003
language
English
LU publication?
yes
id
1ae5a763-e5f8-450b-9b38-7e1cea7f7295 (old id 4179272)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24239836?dopt=Abstract
date added to LUP
2016-04-01 10:57:50
date last changed
2022-01-26 04:14:35
@article{1ae5a763-e5f8-450b-9b38-7e1cea7f7295,
  abstract     = {{The distinguished alternative GM allotypes localized in immunoglobulin constant heavy G chain IGHG (Fcγ) (GM) genes on chromosome 14q32.3 define two unique variants of respectively IgG3, IgG1 and IgG2 subclasses, with different structures and functions. The IGHG allele (allotypes), expressed in homozygous or heterozygous forms, are assessed by new serological methods. Fixed combinations of γ3, γ1 and γ2 allotypes constitute the haplotypes, which are indirect markers of B cells. We highlight the role of homozygous IGHG genes with restricted qualities of IgG subclass molecules and B cells. These common Mendelian IGHG genes respond differently to allergens and infections, both bacterial and viral, and to active and passive immunotherapies. IGHG genes have an impact on diseases such as allergy, immunodeficiency, autoimmunity and malignancy. Association/linkage of different IGHG genes gives information about risk/protection, good or bad prognosis, for improvement of clinical care. The IGHG gene map of healthy Caucasians is registered.}},
  author       = {{Oxelius, Vivi-Anne and Pandey, Janardan P}},
  issn         = {{1521-6616}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{475--486}},
  publisher    = {{Elsevier}},
  series       = {{Clinical Immunology}},
  title        = {{Human immunoglobulin constant heavy G chain (IGHG) (Fcγ) (GM) genes, defining innate variants of IgG molecules and B cells, have impact on disease and therapy.}},
  url          = {{https://lup.lub.lu.se/search/files/2270248/4391246.pdf}},
  doi          = {{10.1016/j.clim.2013.10.003}},
  volume       = {{149}},
  year         = {{2013}},
}