Advanced

RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7

Api, A. M.; Belsito, D.; Bhatia, S.; Bruze, M. LU ; Calow, P.; Dagli, M. L.; Dekant, W.; Fryer, A. D.; Kromidas, L. and La Cava, S., et al. (2016) In Food and Chemical Toxicology 97. p.136-146
Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog benzyl acetate (CAS # 140-11-4) show that this material is not genotoxic nor does it have skin sensitization potential and also provided a MOE > 100 for the repeated dose, developmental and reproductive, and local respiratory toxicity endpoints. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as... (More)

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog benzyl acetate (CAS # 140-11-4) show that this material is not genotoxic nor does it have skin sensitization potential and also provided a MOE > 100 for the repeated dose, developmental and reproductive, and local respiratory toxicity endpoints. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Developmental and reproductive Toxicity, Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Skin sensitization
in
Food and Chemical Toxicology
volume
97
pages
136 - 146
publisher
Elsevier
external identifiers
  • scopus:84997285896
ISSN
0278-6915
DOI
10.1016/j.fct.2016.08.007
language
English
LU publication?
no
id
1afee7c7-c081-4e11-8baa-329c46f87d23
date added to LUP
2016-12-12 12:03:28
date last changed
2017-03-30 14:50:44
@article{1afee7c7-c081-4e11-8baa-329c46f87d23,
  abstract     = {<p>The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog benzyl acetate (CAS # 140-11-4) show that this material is not genotoxic nor does it have skin sensitization potential and also provided a MOE &gt; 100 for the repeated dose, developmental and reproductive, and local respiratory toxicity endpoints. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.</p>},
  author       = {Api, A. M. and Belsito, D. and Bhatia, S. and Bruze, M. and Calow, P. and Dagli, M. L. and Dekant, W. and Fryer, A. D. and Kromidas, L. and La Cava, S. and Lalko, J. F. and Lapczynski, A. and Liebler, D. C. and Politano, V. T. and Ritacco, G. and Salvito, D. and Schultz, T. W. and Shen, J. and Sipes, I. G. and Wall, B. and Wilcox, D. K.},
  issn         = {0278-6915},
  keyword      = {Developmental and reproductive Toxicity,Environmental safety,Genotoxicity,Local respiratory toxicity,Phototoxicity/photoallergenicity,Repeated dose,Skin sensitization},
  language     = {eng},
  month        = {11},
  pages        = {136--146},
  publisher    = {Elsevier},
  series       = {Food and Chemical Toxicology},
  title        = {RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7},
  url          = {http://dx.doi.org/10.1016/j.fct.2016.08.007},
  volume       = {97},
  year         = {2016},
}