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Appropriate/Inappropriate Developed Pain Paths

Schouenborg, J. LU orcid (2010) 5. p.147-154
Abstract

The organization of the somatosensory input to the dorsal horn of the spinal cord has for a long time been viewed as a somatotopical map of the body that is adult-like already at birth. Recent studies indicate, however, that the adult somatotopic organization in the dorsal horn of the spinal cord emerges from an initial floating and diffuse body representation with many inappropriate connections through profound activity-dependent rearrangements of afferent synaptic connections, involving both pruning and sprouting. In this process, tactile fibres appear to guide nociceptive afferents to appropriate targets. Moreover, at the network level, it has been demonstrated that a task-related body representation is engraved through... (More)

The organization of the somatosensory input to the dorsal horn of the spinal cord has for a long time been viewed as a somatotopical map of the body that is adult-like already at birth. Recent studies indicate, however, that the adult somatotopic organization in the dorsal horn of the spinal cord emerges from an initial floating and diffuse body representation with many inappropriate connections through profound activity-dependent rearrangements of afferent synaptic connections, involving both pruning and sprouting. In this process, tactile fibres appear to guide nociceptive afferents to appropriate targets. Moreover, at the network level, it has been demonstrated that a task-related body representation is engraved through learning-dependent mechanisms, termed somatosensory imprinting, during development. Somatosensory imprinting depends on the tactile input that is associated with spontaneous movements that occur during sleep and results in elimination of inappropriate connections and establishment of appropriate connections. This mechanism presumably plays a key role also for the establishment of the recently demonstrated action-based convergence patterns in rostrocaudally elongated zones in the dorsal horn. Hence, recent studies challenge the view of a somatotopical map of the body that is adult-like already at birth.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Development, Learning and memory, Nociception, Plasticity, Spinal cord
host publication
The Senses : A Comprehensive Reference - A Comprehensive Reference
editor
Basbaum, A
volume
5
pages
8 pages
publisher
Elsevier
external identifiers
  • scopus:84882531411
ISBN
978-0-12-370880-9
DOI
10.1016/B978-012370880-9.00151-1
language
English
LU publication?
yes
id
1b150270-f236-4f97-8c02-ef7a332ecd77
date added to LUP
2019-06-25 15:59:20
date last changed
2024-01-01 13:11:33
@inbook{1b150270-f236-4f97-8c02-ef7a332ecd77,
  abstract     = {{<p>The organization of the somatosensory input to the dorsal horn of the spinal cord has for a long time been viewed as a somatotopical map of the body that is adult-like already at birth. Recent studies indicate, however, that the adult somatotopic organization in the dorsal horn of the spinal cord emerges from an initial floating and diffuse body representation with many inappropriate connections through profound activity-dependent rearrangements of afferent synaptic connections, involving both pruning and sprouting. In this process, tactile fibres appear to guide nociceptive afferents to appropriate targets. Moreover, at the network level, it has been demonstrated that a task-related body representation is engraved through learning-dependent mechanisms, termed somatosensory imprinting, during development. Somatosensory imprinting depends on the tactile input that is associated with spontaneous movements that occur during sleep and results in elimination of inappropriate connections and establishment of appropriate connections. This mechanism presumably plays a key role also for the establishment of the recently demonstrated action-based convergence patterns in rostrocaudally elongated zones in the dorsal horn. Hence, recent studies challenge the view of a somatotopical map of the body that is adult-like already at birth.</p>}},
  author       = {{Schouenborg, J.}},
  booktitle    = {{The Senses : A Comprehensive Reference}},
  editor       = {{Basbaum, A}},
  isbn         = {{978-0-12-370880-9}},
  keywords     = {{Development; Learning and memory; Nociception; Plasticity; Spinal cord}},
  language     = {{eng}},
  month        = {{12}},
  pages        = {{147--154}},
  publisher    = {{Elsevier}},
  title        = {{Appropriate/Inappropriate Developed Pain Paths}},
  url          = {{http://dx.doi.org/10.1016/B978-012370880-9.00151-1}},
  doi          = {{10.1016/B978-012370880-9.00151-1}},
  volume       = {{5}},
  year         = {{2010}},
}