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Blood Plasma Reference Material – A Global Resource for Proteomic Research

Malm, Johan LU ; Danmyr, Pia LU ; Nilsson, Rolf ; Appelqvist, Roger LU ; Végvári, Ákos LU and Marko-Varga, György LU (2013) In Journal of Proteome Research 12(7). p.3087-3092
Abstract
There is an ever-increasing awareness and interest within the clinical research field that has creating a large demand for blood fraction samples as well as other clinical samples. The translational research area is another field that demanding for blood samples, used widely in proteomics, genomics, as well as metabolomics. Blood samples are the global most common biological samples that find its use in a broad variety of applications in Life Science. We hereby introduce a new reference blood plasma (EDTA) that is aimed as a global resource for the Proteomics community. We have developed these reference plasma standards by defining the Control group as those with CRP levels <3mg/L and a Disease group with CRP ranges >30 mg/L. In... (More)
There is an ever-increasing awareness and interest within the clinical research field that has creating a large demand for blood fraction samples as well as other clinical samples. The translational research area is another field that demanding for blood samples, used widely in proteomics, genomics, as well as metabolomics. Blood samples are the global most common biological samples that find its use in a broad variety of applications in Life Science. We hereby introduce a new reference blood plasma (EDTA) that is aimed as a global resource for the Proteomics community. We have developed these reference plasma standards by defining the Control group as those with CRP levels <3mg/L and a Disease group with CRP ranges >30 mg/L. In these references we have used both newborn children 1-2 weeks, as well as youngsters 10-15 years, and middle aged 30-50 years, and elderly patients at the ages of 65+. The total number of these reference plasma pools was 80 patients in each group. We provide data on the developments and characteristics of the reference blood plasma standards, as well as what is used by the team members at the respective laboratories. The standards have been evaluated by pilot sample processing in biobanking operations, and are currently a resource that allows the Proteomic society to perform quantitative proteomic studies. By the use of high quality reference plasma samples, global initiatives, such as the Chromosome Human Proteome Project (C-HPP), will benefit as one scientific program when the entire human proteome is mapped and linked to human diseases. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
C-HPP, blood plasma reference material
in
Journal of Proteome Research
volume
12
issue
7
pages
3087 - 3092
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000321605700002
  • scopus:84879910249
  • pmid:23701512
ISSN
1535-3893
DOI
10.1021/pr400131r
language
English
LU publication?
yes
id
1b1d5d9b-7fad-498f-9452-10df61208153 (old id 3459912)
date added to LUP
2016-04-01 09:48:47
date last changed
2022-03-19 06:34:48
@article{1b1d5d9b-7fad-498f-9452-10df61208153,
  abstract     = {{There is an ever-increasing awareness and interest within the clinical research field that has creating a large demand for blood fraction samples as well as other clinical samples. The translational research area is another field that demanding for blood samples, used widely in proteomics, genomics, as well as metabolomics. Blood samples are the global most common biological samples that find its use in a broad variety of applications in Life Science. We hereby introduce a new reference blood plasma (EDTA) that is aimed as a global resource for the Proteomics community. We have developed these reference plasma standards by defining the Control group as those with CRP levels &lt;3mg/L and a Disease group with CRP ranges &gt;30 mg/L. In these references we have used both newborn children 1-2 weeks, as well as youngsters 10-15 years, and middle aged 30-50 years, and elderly patients at the ages of 65+. The total number of these reference plasma pools was 80 patients in each group. We provide data on the developments and characteristics of the reference blood plasma standards, as well as what is used by the team members at the respective laboratories. The standards have been evaluated by pilot sample processing in biobanking operations, and are currently a resource that allows the Proteomic society to perform quantitative proteomic studies. By the use of high quality reference plasma samples, global initiatives, such as the Chromosome Human Proteome Project (C-HPP), will benefit as one scientific program when the entire human proteome is mapped and linked to human diseases.}},
  author       = {{Malm, Johan and Danmyr, Pia and Nilsson, Rolf and Appelqvist, Roger and Végvári, Ákos and Marko-Varga, György}},
  issn         = {{1535-3893}},
  keywords     = {{C-HPP; blood plasma reference material}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{3087--3092}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Journal of Proteome Research}},
  title        = {{Blood Plasma Reference Material – A Global Resource for Proteomic Research}},
  url          = {{http://dx.doi.org/10.1021/pr400131r}},
  doi          = {{10.1021/pr400131r}},
  volume       = {{12}},
  year         = {{2013}},
}