Renal inflammatory and oxidative and metabolic changes after 6 weeks of cafeteria diet in rats
(2016) In Jornal Brasileiro de Nefrologia 38(1). p.9-14- Abstract
INTRODUCTION: Obesity is a disease in which inflammation is directly involved and can lead to impaired renal function.
OBJECTIVE: To evaluate the influence of short term exposure to cafeteria diet on kidney tissue inflammation and advanced glycation end products (AGEs) in the rat plasma.
METHODS: Male Wistar rats (10 weeks of age, weighing 350 g) were assigned to receive commercial chow diet (C; n = 8 animals/group, 5% of energy from fat) or cafeteria diet (CAF-D, n = 8 animals/group: 29% energy fat) and sucrose in drinking water (300 g/L) for 6 weeks.
RESULTS: adiposity index at six weeks was higher in CAF-D group compared to C. The same behavior was observed for plasma levels of glucose, triglycerides, leptin,... (More)
INTRODUCTION: Obesity is a disease in which inflammation is directly involved and can lead to impaired renal function.
OBJECTIVE: To evaluate the influence of short term exposure to cafeteria diet on kidney tissue inflammation and advanced glycation end products (AGEs) in the rat plasma.
METHODS: Male Wistar rats (10 weeks of age, weighing 350 g) were assigned to receive commercial chow diet (C; n = 8 animals/group, 5% of energy from fat) or cafeteria diet (CAF-D, n = 8 animals/group: 29% energy fat) and sucrose in drinking water (300 g/L) for 6 weeks.
RESULTS: adiposity index at six weeks was higher in CAF-D group compared to C. The same behavior was observed for plasma levels of glucose, triglycerides, leptin, insulin and AGEs. The gene expression of IL-6 and TNF-α in renal tissue was higher in CAF-D group and no significant difference in adipose tissue. There was no increase of these cytokines in plasma and kidney or histologically. There was a significant decrease of adiponectin in the CAF-D group.
CONCLUSION: The short exposure CAF-D reflects changes in metabolism, increased plasma levels of AGEs, which may reflect the increased expression of inflammatory cytokines in the kidney.
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- author
- Navarro, Maria Eugênia Lopes ; Santos, Klinsmann Carolo Dos LU ; Nascimento, André Ferreira do ; Francisqueti, Fabiane Valentini ; Minatel, Igor Otávio ; Pierine, Damiana Tortolero ; Luvizotto, Renata Azevedo de Melo ; Ferreira, Ana Lúcia A ; Campos, Dijon Henrique Salomé de and Corrêa, Camila Renata
- publishing date
- 2016-03
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adiposity, Animals, Cytokines/metabolism, Diet/adverse effects, Glycation End Products, Advanced/blood, Inflammation/metabolism, Kidney/metabolism, Male, Rats, Rats, Wistar
- in
- Jornal Brasileiro de Nefrologia
- volume
- 38
- issue
- 1
- pages
- 6 pages
- publisher
- Sociedade Brasileira de Nefrologia
- external identifiers
-
- scopus:85031732062
- pmid:27049359
- ISSN
- 0101-2800
- DOI
- 10.5935/0101-2800.20160003
- language
- English
- LU publication?
- no
- id
- 1b2dc0e1-33de-436c-9de6-dcc6d6649f01
- date added to LUP
- 2019-03-28 18:17:59
- date last changed
- 2024-06-14 23:52:42
@article{1b2dc0e1-33de-436c-9de6-dcc6d6649f01,
abstract = {{<p>INTRODUCTION: Obesity is a disease in which inflammation is directly involved and can lead to impaired renal function.</p><p>OBJECTIVE: To evaluate the influence of short term exposure to cafeteria diet on kidney tissue inflammation and advanced glycation end products (AGEs) in the rat plasma.</p><p>METHODS: Male Wistar rats (10 weeks of age, weighing 350 g) were assigned to receive commercial chow diet (C; n = 8 animals/group, 5% of energy from fat) or cafeteria diet (CAF-D, n = 8 animals/group: 29% energy fat) and sucrose in drinking water (300 g/L) for 6 weeks.</p><p>RESULTS: adiposity index at six weeks was higher in CAF-D group compared to C. The same behavior was observed for plasma levels of glucose, triglycerides, leptin, insulin and AGEs. The gene expression of IL-6 and TNF-α in renal tissue was higher in CAF-D group and no significant difference in adipose tissue. There was no increase of these cytokines in plasma and kidney or histologically. There was a significant decrease of adiponectin in the CAF-D group.</p><p>CONCLUSION: The short exposure CAF-D reflects changes in metabolism, increased plasma levels of AGEs, which may reflect the increased expression of inflammatory cytokines in the kidney.</p>}},
author = {{Navarro, Maria Eugênia Lopes and Santos, Klinsmann Carolo Dos and Nascimento, André Ferreira do and Francisqueti, Fabiane Valentini and Minatel, Igor Otávio and Pierine, Damiana Tortolero and Luvizotto, Renata Azevedo de Melo and Ferreira, Ana Lúcia A and Campos, Dijon Henrique Salomé de and Corrêa, Camila Renata}},
issn = {{0101-2800}},
keywords = {{Adiposity; Animals; Cytokines/metabolism; Diet/adverse effects; Glycation End Products, Advanced/blood; Inflammation/metabolism; Kidney/metabolism; Male; Rats; Rats, Wistar}},
language = {{eng}},
number = {{1}},
pages = {{9--14}},
publisher = {{Sociedade Brasileira de Nefrologia}},
series = {{Jornal Brasileiro de Nefrologia}},
title = {{Renal inflammatory and oxidative and metabolic changes after 6 weeks of cafeteria diet in rats}},
url = {{http://dx.doi.org/10.5935/0101-2800.20160003}},
doi = {{10.5935/0101-2800.20160003}},
volume = {{38}},
year = {{2016}},
}