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Animal modelling of interstitial cystitis/bladder pain syndrome

Birder, Lori and Andersson, Karl Erik LU (2018) In International Neurourology Journal 22. p.3-9
Abstract

The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1)... (More)

The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1) bladder-centric models, (2) models with complex mechanisms, and (3) psychological and physical stressors/natural disease models. It is obvious that all aspects of the human disease cannot be mimicked by a single model. It may be the case that several models, each contributing to a piece of the puzzle, are required to recreate a reasonable picture of the pathophysiology and time course of the disease(s) diagnosed as IC/BPS, and thus to identify reasonable targets for treatment.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animal models, Bladder pain syndrome, Inflammation, Interstitial cystitis, Mucosa, Stress
in
International Neurourology Journal
volume
22
pages
3 - 9
external identifiers
  • scopus:85041213119
ISSN
2093-4777
DOI
10.5213/inj.1835062.531
language
English
LU publication?
yes
id
1b5aa95a-311f-4c71-a62f-fcceb1c127bb
date added to LUP
2018-02-23 10:02:39
date last changed
2018-07-15 04:47:42
@article{1b5aa95a-311f-4c71-a62f-fcceb1c127bb,
  abstract     = {<p>The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1) bladder-centric models, (2) models with complex mechanisms, and (3) psychological and physical stressors/natural disease models. It is obvious that all aspects of the human disease cannot be mimicked by a single model. It may be the case that several models, each contributing to a piece of the puzzle, are required to recreate a reasonable picture of the pathophysiology and time course of the disease(s) diagnosed as IC/BPS, and thus to identify reasonable targets for treatment.</p>},
  author       = {Birder, Lori and Andersson, Karl Erik},
  issn         = {2093-4777},
  keyword      = {Animal models,Bladder pain syndrome,Inflammation,Interstitial cystitis,Mucosa,Stress},
  language     = {eng},
  month        = {01},
  pages        = {3--9},
  series       = {International Neurourology Journal},
  title        = {Animal modelling of interstitial cystitis/bladder pain syndrome},
  url          = {http://dx.doi.org/10.5213/inj.1835062.531},
  volume       = {22},
  year         = {2018},
}