Animal modelling of interstitial cystitis/bladder pain syndrome
Birder, Lori and Andersson, Karl Erik LU
(2018)
In International Neurourology Journal
22.
p.3-9
- Abstract
The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1)... (More)
The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1) bladder-centric models, (2) models with complex mechanisms, and (3) psychological and physical stressors/natural disease models. It is obvious that all aspects of the human disease cannot be mimicked by a single model. It may be the case that several models, each contributing to a piece of the puzzle, are required to recreate a reasonable picture of the pathophysiology and time course of the disease(s) diagnosed as IC/BPS, and thus to identify reasonable targets for treatment.
(Less)
- author
- Birder, Lori
and Andersson, Karl Erik
LU
- organization
- publishing date
- 2018-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animal models, Bladder pain syndrome, Inflammation, Interstitial cystitis, Mucosa, Stress
- in
- International Neurourology Journal
- volume
- 22
- pages
- 3 - 9
- publisher
- Korean Association of Medical Journal Editors
- external identifiers
-
- pmid:29385788
- scopus:85041213119
- ISSN
- 2093-4777
- DOI
- 10.5213/inj.1835062.531
- language
- English
- LU publication?
- yes
- id
- 1b5aa95a-311f-4c71-a62f-fcceb1c127bb
- date added to LUP
- 2018-02-23 10:02:39
- date last changed
- 2024-06-25 13:01:04
@article{1b5aa95a-311f-4c71-a62f-fcceb1c127bb,
abstract = {{<p>The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1) bladder-centric models, (2) models with complex mechanisms, and (3) psychological and physical stressors/natural disease models. It is obvious that all aspects of the human disease cannot be mimicked by a single model. It may be the case that several models, each contributing to a piece of the puzzle, are required to recreate a reasonable picture of the pathophysiology and time course of the disease(s) diagnosed as IC/BPS, and thus to identify reasonable targets for treatment.</p>}},
author = {{Birder, Lori and Andersson, Karl Erik}},
issn = {{2093-4777}},
keywords = {{Animal models; Bladder pain syndrome; Inflammation; Interstitial cystitis; Mucosa; Stress}},
language = {{eng}},
month = {{01}},
pages = {{3--9}},
publisher = {{Korean Association of Medical Journal Editors}},
series = {{International Neurourology Journal}},
title = {{Animal modelling of interstitial cystitis/bladder pain syndrome}},
url = {{http://dx.doi.org/10.5213/inj.1835062.531}},
doi = {{10.5213/inj.1835062.531}},
volume = {{22}},
year = {{2018}},
}