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Brain energy metabolism : A roadmap for future research

Rae, Caroline D. ; Baur, Joseph A. ; Borges, Karin ; Dienel, Gerald ; Díaz-García, Carlos Manlio ; Douglass, Starlette R. ; Drew, Kelly ; Duarte, João M  N LU orcid ; Duran, Jordi and Kann, Oliver , et al. (2024) In Journal of Neurochemistry
Abstract

Although we have learned much about how the brain fuels its functions over the last decades, there remains much still to discover in an organ that is so complex. This article lays out major gaps in our knowledge of interrelationships between brain metabolism and brain function, including biochemical, cellular, and subcellular aspects of functional metabolism and its imaging in adult brain, as well as during development, aging, and disease. 

The focus is on unknowns in metabolism of major brain substrates and associated transporters, the roles of insulin and of lipid droplets, the emerging role of metabolism in microglia, mysteries about the major brain cofactor and signaling molecule NAD+, as well as unsolved problems... (More)

Although we have learned much about how the brain fuels its functions over the last decades, there remains much still to discover in an organ that is so complex. This article lays out major gaps in our knowledge of interrelationships between brain metabolism and brain function, including biochemical, cellular, and subcellular aspects of functional metabolism and its imaging in adult brain, as well as during development, aging, and disease. 

The focus is on unknowns in metabolism of major brain substrates and associated transporters, the roles of insulin and of lipid droplets, the emerging role of metabolism in microglia, mysteries about the major brain cofactor and signaling molecule NAD+, as well as unsolved problems underlying brain metabolism in pathologies such as traumatic brain injury, epilepsy, and metabolic downregulation during hibernation. It describes our current level of understanding of these facets of brain energy metabolism as well as a roadmap for future research.

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organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
acetate, aerobic glycolysis, GLUT4, insulin, noradrenaline
in
Journal of Neurochemistry
publisher
Wiley-Blackwell
external identifiers
  • pmid:38183680
  • scopus:85181446669
ISSN
0022-3042
DOI
10.1111/jnc.16032
language
English
LU publication?
yes
id
1b6c1b53-7c3e-4e1e-bfa5-da409ba6e3eb
date added to LUP
2024-02-08 13:10:44
date last changed
2024-04-23 16:07:17
@article{1b6c1b53-7c3e-4e1e-bfa5-da409ba6e3eb,
  abstract     = {{<p>Although we have learned much about how the brain fuels its functions over the last decades, there remains much still to discover in an organ that is so complex. This article lays out major gaps in our knowledge of interrelationships between brain metabolism and brain function, including biochemical, cellular, and subcellular aspects of functional metabolism and its imaging in adult brain, as well as during development, aging, and disease. </p><p>The focus is on unknowns in metabolism of major brain substrates and associated transporters, the roles of insulin and of lipid droplets, the emerging role of metabolism in microglia, mysteries about the major brain cofactor and signaling molecule NAD<sup>+</sup>, as well as unsolved problems underlying brain metabolism in pathologies such as traumatic brain injury, epilepsy, and metabolic downregulation during hibernation. It describes our current level of understanding of these facets of brain energy metabolism as well as a roadmap for future research.</p>}},
  author       = {{Rae, Caroline D. and Baur, Joseph A. and Borges, Karin and Dienel, Gerald and Díaz-García, Carlos Manlio and Douglass, Starlette R. and Drew, Kelly and Duarte, João M  N and Duran, Jordi and Kann, Oliver and Kristian, Tibor and Lee-Liu, Dasfne and Lindquist, Britta E. and McNay, Ewan C. and Robinson, Michael B. and Rothman, Douglas L. and Rowlands, Benjamin D. and Ryan, Timothy A. and Scafidi, Joseph and Scafidi, Susanna and Shuttleworth, C. William and Swanson, Raymond A. and Uruk, Gökhan and Vardjan, Nina and Zorec, Robert and McKenna, Mary C.}},
  issn         = {{0022-3042}},
  keywords     = {{acetate; aerobic glycolysis; GLUT4; insulin; noradrenaline}},
  language     = {{eng}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Neurochemistry}},
  title        = {{Brain energy metabolism : A roadmap for future research}},
  url          = {{http://dx.doi.org/10.1111/jnc.16032}},
  doi          = {{10.1111/jnc.16032}},
  year         = {{2024}},
}