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Pharmacotherapy for Nocturia

Andersson, Karl Erik LU and Van Kerrebroeck, Philip (2018) In Current Urology Reports 19(1).
Abstract

PURPOSE OF REVIEW: To assess current pharmacological principles used for treatment of nocturia/nocturnal polyuria.

RECENT FINDINGS: The pathophysiology of nocturia is often multifactorial, but two main mechanisms have been identified, occurring alone or in combination: low functional bladder capacity and nocturnal polyuria. The multifactorial pathophysiology not only implies several possible targets for therapeutic intervention but also means that it is unlikely that one treatment modality including drugs will be successful in all patients. Drugs approved for the treatment of male LUTS and male and female OAB are known to be far more effective for treatment of the daytime symptoms than for nocturia. Several pharmacological... (More)

PURPOSE OF REVIEW: To assess current pharmacological principles used for treatment of nocturia/nocturnal polyuria.

RECENT FINDINGS: The pathophysiology of nocturia is often multifactorial, but two main mechanisms have been identified, occurring alone or in combination: low functional bladder capacity and nocturnal polyuria. The multifactorial pathophysiology not only implies several possible targets for therapeutic intervention but also means that it is unlikely that one treatment modality including drugs will be successful in all patients. Drugs approved for the treatment of male LUTS and male and female OAB are known to be far more effective for treatment of the daytime symptoms than for nocturia. Several pharmacological principles have been tested with varying success. The treatment of choice should depend upon the main underlying cause, thus aiming primarily to increase bladder capacity by counteracting detrusor overactivity and/or reducing nocturnal polyuria. Using current available agents, effective, personalized treatment should be designed taking into account gender, co-morbidities, and identified etiological factors. However, there is a medical need for new, approved drugs for treatments for patients with nocturia.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Global polyuria, Nocturnal polyuria, Overactive bladder, Pharmacological principles, Reduced bladder capacity
in
Current Urology Reports
volume
19
issue
1
pages
1 pages
publisher
Current Medicine Group LLC
external identifiers
  • scopus:85049246275
ISSN
1527-2737
DOI
10.1007/s11934-018-0750-y
language
English
LU publication?
yes
id
1b9d59a9-15b3-4051-9d66-daab56319e99
date added to LUP
2018-07-17 10:58:14
date last changed
2018-09-16 04:56:17
@article{1b9d59a9-15b3-4051-9d66-daab56319e99,
  abstract     = {<p>PURPOSE OF REVIEW: To assess current pharmacological principles used for treatment of nocturia/nocturnal polyuria.</p><p>RECENT FINDINGS: The pathophysiology of nocturia is often multifactorial, but two main mechanisms have been identified, occurring alone or in combination: low functional bladder capacity and nocturnal polyuria. The multifactorial pathophysiology not only implies several possible targets for therapeutic intervention but also means that it is unlikely that one treatment modality including drugs will be successful in all patients. Drugs approved for the treatment of male LUTS and male and female OAB are known to be far more effective for treatment of the daytime symptoms than for nocturia. Several pharmacological principles have been tested with varying success. The treatment of choice should depend upon the main underlying cause, thus aiming primarily to increase bladder capacity by counteracting detrusor overactivity and/or reducing nocturnal polyuria. Using current available agents, effective, personalized treatment should be designed taking into account gender, co-morbidities, and identified etiological factors. However, there is a medical need for new, approved drugs for treatments for patients with nocturia.</p>},
  author       = {Andersson, Karl Erik and Van Kerrebroeck, Philip},
  issn         = {1527-2737},
  keyword      = {Global polyuria,Nocturnal polyuria,Overactive bladder,Pharmacological principles,Reduced bladder capacity},
  language     = {eng},
  month        = {02},
  number       = {1},
  pages        = {1},
  publisher    = {Current Medicine Group LLC},
  series       = {Current Urology Reports},
  title        = {Pharmacotherapy for Nocturia},
  url          = {http://dx.doi.org/10.1007/s11934-018-0750-y},
  volume       = {19},
  year         = {2018},
}