Some substances with proposed digitalis-like effects evaluated on platelet functions sensitive for cardiac glycosides
(1991) In General Pharamacology 22(4). p.749-753- Abstract
1. 1. The effects of progresterone, corticosterone 21-acetate, chlormadinone acetate, dehydroepi-androsterone 3-sulfate and lysophosphatidylcholine were tested on 86Rb-uptake, 3H-5-HT-uptake, ADP-induced aggregation and 5-HT-induced shape change in human platelets. Ouabain and digoxin were used for reference. 2. 2. Ouabain and digoxin 10-5 M inhibited 86Rb-uptake by more than 85%, and chlormadinone acetate 10-5 M by 20%. The other substances had no effects. 3. 3. Ouabain and digoxin were potent inhibitors on 3H-5-HT-uptake, whereas chlormadinone acetate had no effect. 4. 4. Ouabain and digoxin increased ADP-induced aggregation but chlormadinone acetate decreased it.... (More)
1. 1. The effects of progresterone, corticosterone 21-acetate, chlormadinone acetate, dehydroepi-androsterone 3-sulfate and lysophosphatidylcholine were tested on 86Rb-uptake, 3H-5-HT-uptake, ADP-induced aggregation and 5-HT-induced shape change in human platelets. Ouabain and digoxin were used for reference. 2. 2. Ouabain and digoxin 10-5 M inhibited 86Rb-uptake by more than 85%, and chlormadinone acetate 10-5 M by 20%. The other substances had no effects. 3. 3. Ouabain and digoxin were potent inhibitors on 3H-5-HT-uptake, whereas chlormadinone acetate had no effect. 4. 4. Ouabain and digoxin increased ADP-induced aggregation but chlormadinone acetate decreased it. 5-HT-induced shape change was decreased by ouabain and digoxin, and to a lesser extent by chlormadinone acetate and its vehicle (ethanol 1.0%).
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- author
- Andersson, Tomas L.G. LU ; Zygmunt, Peter LU and Vinge, Ellen LU
- publishing date
- 1991-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- General Pharamacology
- volume
- 22
- issue
- 4
- pages
- 5 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:0025753816
- pmid:1718814
- ISSN
- 0306-3623
- DOI
- 10.1016/0306-3623(91)90090-S
- language
- English
- LU publication?
- no
- id
- 1bb1f51f-f8f8-4bef-a038-7f8ddb7be506
- date added to LUP
- 2019-05-31 21:44:01
- date last changed
- 2024-01-01 09:01:58
@article{1bb1f51f-f8f8-4bef-a038-7f8ddb7be506, abstract = {{<p>1. 1. The effects of progresterone, corticosterone 21-acetate, chlormadinone acetate, dehydroepi-androsterone 3-sulfate and lysophosphatidylcholine were tested on <sup>86</sup>Rb-uptake, <sup>3</sup>H-5-HT-uptake, ADP-induced aggregation and 5-HT-induced shape change in human platelets. Ouabain and digoxin were used for reference. 2. 2. Ouabain and digoxin 10<sup>-5</sup> M inhibited <sup>86</sup>Rb-uptake by more than 85%, and chlormadinone acetate 10<sup>-5</sup> M by 20%. The other substances had no effects. 3. 3. Ouabain and digoxin were potent inhibitors on <sup>3</sup>H-5-HT-uptake, whereas chlormadinone acetate had no effect. 4. 4. Ouabain and digoxin increased ADP-induced aggregation but chlormadinone acetate decreased it. 5-HT-induced shape change was decreased by ouabain and digoxin, and to a lesser extent by chlormadinone acetate and its vehicle (ethanol 1.0%).</p>}}, author = {{Andersson, Tomas L.G. and Zygmunt, Peter and Vinge, Ellen}}, issn = {{0306-3623}}, language = {{eng}}, month = {{01}}, number = {{4}}, pages = {{749--753}}, publisher = {{Elsevier}}, series = {{General Pharamacology}}, title = {{Some substances with proposed digitalis-like effects evaluated on platelet functions sensitive for cardiac glycosides}}, url = {{http://dx.doi.org/10.1016/0306-3623(91)90090-S}}, doi = {{10.1016/0306-3623(91)90090-S}}, volume = {{22}}, year = {{1991}}, }