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Some substances with proposed digitalis-like effects evaluated on platelet functions sensitive for cardiac glycosides

Andersson, Tomas L.G. LU ; Zygmunt, Peter LU orcid and Vinge, Ellen LU (1991) In General Pharamacology 22(4). p.749-753
Abstract

1. 1. The effects of progresterone, corticosterone 21-acetate, chlormadinone acetate, dehydroepi-androsterone 3-sulfate and lysophosphatidylcholine were tested on 86Rb-uptake, 3H-5-HT-uptake, ADP-induced aggregation and 5-HT-induced shape change in human platelets. Ouabain and digoxin were used for reference. 2. 2. Ouabain and digoxin 10-5 M inhibited 86Rb-uptake by more than 85%, and chlormadinone acetate 10-5 M by 20%. The other substances had no effects. 3. 3. Ouabain and digoxin were potent inhibitors on 3H-5-HT-uptake, whereas chlormadinone acetate had no effect. 4. 4. Ouabain and digoxin increased ADP-induced aggregation but chlormadinone acetate decreased it.... (More)

1. 1. The effects of progresterone, corticosterone 21-acetate, chlormadinone acetate, dehydroepi-androsterone 3-sulfate and lysophosphatidylcholine were tested on 86Rb-uptake, 3H-5-HT-uptake, ADP-induced aggregation and 5-HT-induced shape change in human platelets. Ouabain and digoxin were used for reference. 2. 2. Ouabain and digoxin 10-5 M inhibited 86Rb-uptake by more than 85%, and chlormadinone acetate 10-5 M by 20%. The other substances had no effects. 3. 3. Ouabain and digoxin were potent inhibitors on 3H-5-HT-uptake, whereas chlormadinone acetate had no effect. 4. 4. Ouabain and digoxin increased ADP-induced aggregation but chlormadinone acetate decreased it. 5-HT-induced shape change was decreased by ouabain and digoxin, and to a lesser extent by chlormadinone acetate and its vehicle (ethanol 1.0%).

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author
; and
publishing date
type
Contribution to journal
publication status
published
subject
in
General Pharamacology
volume
22
issue
4
pages
5 pages
publisher
Elsevier
external identifiers
  • scopus:0025753816
  • pmid:1718814
ISSN
0306-3623
DOI
10.1016/0306-3623(91)90090-S
language
English
LU publication?
no
id
1bb1f51f-f8f8-4bef-a038-7f8ddb7be506
date added to LUP
2019-05-31 21:44:01
date last changed
2024-01-01 09:01:58
@article{1bb1f51f-f8f8-4bef-a038-7f8ddb7be506,
  abstract     = {{<p>1. 1. The effects of progresterone, corticosterone 21-acetate, chlormadinone acetate, dehydroepi-androsterone 3-sulfate and lysophosphatidylcholine were tested on <sup>86</sup>Rb-uptake, <sup>3</sup>H-5-HT-uptake, ADP-induced aggregation and 5-HT-induced shape change in human platelets. Ouabain and digoxin were used for reference. 2. 2. Ouabain and digoxin 10<sup>-5</sup> M inhibited <sup>86</sup>Rb-uptake by more than 85%, and chlormadinone acetate 10<sup>-5</sup> M by 20%. The other substances had no effects. 3. 3. Ouabain and digoxin were potent inhibitors on <sup>3</sup>H-5-HT-uptake, whereas chlormadinone acetate had no effect. 4. 4. Ouabain and digoxin increased ADP-induced aggregation but chlormadinone acetate decreased it. 5-HT-induced shape change was decreased by ouabain and digoxin, and to a lesser extent by chlormadinone acetate and its vehicle (ethanol 1.0%).</p>}},
  author       = {{Andersson, Tomas L.G. and Zygmunt, Peter and Vinge, Ellen}},
  issn         = {{0306-3623}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{4}},
  pages        = {{749--753}},
  publisher    = {{Elsevier}},
  series       = {{General Pharamacology}},
  title        = {{Some substances with proposed digitalis-like effects evaluated on platelet functions sensitive for cardiac glycosides}},
  url          = {{http://dx.doi.org/10.1016/0306-3623(91)90090-S}},
  doi          = {{10.1016/0306-3623(91)90090-S}},
  volume       = {{22}},
  year         = {{1991}},
}