Advanced

Pharmacological treatment of vertigo

Pyykkö, I.; Magnusson, M LU ; Schalén, L LU and Enbom, Håkan (1988) In Acta Oto-Laryngologica, Supplement 105(S455). p.77-81
Abstract

A review of the treatment of vestibular disorders with drugs is presented. In animal experiments, administration of certain drugs, e.g. alcohol, barbiturates and chlorpromazine, retards the vestibular compensation, while others, e.g. caffeine, amphetamine and ACTH, accelerate the compensation. In compensated animals, some drugs produce overcompensation and some decompensation. A double-blind, randomized trial of the effect of scopolamine and dimenhydrinate in patients with vertigo of varying origin showed, as compared with placebo, that these drugs did not significantly alleviate the vestibular imbalance. The reason for the poor efficacy of the treatment may have been overcompensation of vestibular function loss and adverse effects... (More)

A review of the treatment of vestibular disorders with drugs is presented. In animal experiments, administration of certain drugs, e.g. alcohol, barbiturates and chlorpromazine, retards the vestibular compensation, while others, e.g. caffeine, amphetamine and ACTH, accelerate the compensation. In compensated animals, some drugs produce overcompensation and some decompensation. A double-blind, randomized trial of the effect of scopolamine and dimenhydrinate in patients with vertigo of varying origin showed, as compared with placebo, that these drugs did not significantly alleviate the vestibular imbalance. The reason for the poor efficacy of the treatment may have been overcompensation of vestibular function loss and adverse effects caused by the drugs. Care should be taken that the drugs used do not retard the vestibular compensation caused by the central nervous system.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Dimenhydrinate, Humans, Meniere Disease, Motion Sickness, Scopolamine Hydrobromide, Vertigo, Vestibule, Labyrinth, Journal Article, Review
in
Acta Oto-Laryngologica, Supplement
volume
105
issue
S455
pages
77 - 81
publisher
Scandinavian University Press
external identifiers
  • scopus:0024230055
ISSN
0365-5237
language
English
LU publication?
no
id
1bf09ce7-4432-42d3-8c31-ffe7fbb836ec
date added to LUP
2017-05-03 13:03:02
date last changed
2017-08-13 05:07:12
@article{1bf09ce7-4432-42d3-8c31-ffe7fbb836ec,
  abstract     = {<p>A review of the treatment of vestibular disorders with drugs is presented. In animal experiments, administration of certain drugs, e.g. alcohol, barbiturates and chlorpromazine, retards the vestibular compensation, while others, e.g. caffeine, amphetamine and ACTH, accelerate the compensation. In compensated animals, some drugs produce overcompensation and some decompensation. A double-blind, randomized trial of the effect of scopolamine and dimenhydrinate in patients with vertigo of varying origin showed, as compared with placebo, that these drugs did not significantly alleviate the vestibular imbalance. The reason for the poor efficacy of the treatment may have been overcompensation of vestibular function loss and adverse effects caused by the drugs. Care should be taken that the drugs used do not retard the vestibular compensation caused by the central nervous system.</p>},
  author       = {Pyykkö, I. and Magnusson, M and Schalén, L and Enbom, Håkan},
  issn         = {0365-5237},
  keyword      = {Animals,Dimenhydrinate,Humans,Meniere Disease,Motion Sickness,Scopolamine Hydrobromide,Vertigo,Vestibule, Labyrinth,Journal Article,Review},
  language     = {eng},
  number       = {S455},
  pages        = {77--81},
  publisher    = {Scandinavian University Press},
  series       = {Acta Oto-Laryngologica, Supplement},
  title        = {Pharmacological treatment of vertigo},
  volume       = {105},
  year         = {1988},
}