Pharmacological treatment of vertigo
Pyykkö, I. ; Magnusson, M LU
; Schalén, L
LU
and Enbom, Håkan
(1988)
In Acta Oto-Laryngologica, Supplement
105(S455).
p.77-81
- Abstract
A review of the treatment of vestibular disorders with drugs is presented. In animal experiments, administration of certain drugs, e.g. alcohol, barbiturates and chlorpromazine, retards the vestibular compensation, while others, e.g. caffeine, amphetamine and ACTH, accelerate the compensation. In compensated animals, some drugs produce overcompensation and some decompensation. A double-blind, randomized trial of the effect of scopolamine and dimenhydrinate in patients with vertigo of varying origin showed, as compared with placebo, that these drugs did not significantly alleviate the vestibular imbalance. The reason for the poor efficacy of the treatment may have been overcompensation of vestibular function loss and adverse effects... (More)
A review of the treatment of vestibular disorders with drugs is presented. In animal experiments, administration of certain drugs, e.g. alcohol, barbiturates and chlorpromazine, retards the vestibular compensation, while others, e.g. caffeine, amphetamine and ACTH, accelerate the compensation. In compensated animals, some drugs produce overcompensation and some decompensation. A double-blind, randomized trial of the effect of scopolamine and dimenhydrinate in patients with vertigo of varying origin showed, as compared with placebo, that these drugs did not significantly alleviate the vestibular imbalance. The reason for the poor efficacy of the treatment may have been overcompensation of vestibular function loss and adverse effects caused by the drugs. Care should be taken that the drugs used do not retard the vestibular compensation caused by the central nervous system.
(Less)
- author
- Pyykkö, I.
; Magnusson, M
LU
; Schalén, L
LU
and Enbom, Håkan
- publishing date
- 1988
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Dimenhydrinate, Humans, Meniere Disease, Motion Sickness, Scopolamine Hydrobromide, Vertigo, Vestibule, Labyrinth, Journal Article, Review
- in
- Acta Oto-Laryngologica, Supplement
- volume
- 105
- issue
- S455
- pages
- 77 - 81
- publisher
- Scandinavian University Press
- external identifiers
-
- pmid:3064540
- scopus:0024230055
- ISSN
- 0365-5237
- language
- English
- LU publication?
- no
- id
- 1bf09ce7-4432-42d3-8c31-ffe7fbb836ec
- date added to LUP
- 2017-05-03 13:03:02
- date last changed
- 2024-01-13 20:03:09
@article{1bf09ce7-4432-42d3-8c31-ffe7fbb836ec,
abstract = {{<p>A review of the treatment of vestibular disorders with drugs is presented. In animal experiments, administration of certain drugs, e.g. alcohol, barbiturates and chlorpromazine, retards the vestibular compensation, while others, e.g. caffeine, amphetamine and ACTH, accelerate the compensation. In compensated animals, some drugs produce overcompensation and some decompensation. A double-blind, randomized trial of the effect of scopolamine and dimenhydrinate in patients with vertigo of varying origin showed, as compared with placebo, that these drugs did not significantly alleviate the vestibular imbalance. The reason for the poor efficacy of the treatment may have been overcompensation of vestibular function loss and adverse effects caused by the drugs. Care should be taken that the drugs used do not retard the vestibular compensation caused by the central nervous system.</p>}},
author = {{Pyykkö, I. and Magnusson, M and Schalén, L and Enbom, Håkan}},
issn = {{0365-5237}},
keywords = {{Animals; Dimenhydrinate; Humans; Meniere Disease; Motion Sickness; Scopolamine Hydrobromide; Vertigo; Vestibule, Labyrinth; Journal Article; Review}},
language = {{eng}},
number = {{S455}},
pages = {{77--81}},
publisher = {{Scandinavian University Press}},
series = {{Acta Oto-Laryngologica, Supplement}},
title = {{Pharmacological treatment of vertigo}},
volume = {{105}},
year = {{1988}},
}