Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Surgical resection of a retroperitoneal liposarcoma producing insulin-like growth factor II : a case report

Nishiwaki, Noriyuki ; Mikuriya, Yoshihiro ; Takatsu, Fumiaki ; Ochiai, Ryoji ; Kakishita, Tomokazu ; Kobayashi, Naruyuki ; Kobatake, Takaya ; Hato, Shinji ; Teramoto, Norihiro and Nagao, Mototsugu LU , et al. (2023) In Surgical case reports 9.
Abstract

BACKGROUND: Tumor-produced high molecular weight insulin-like growth factor-II (big insulin-like growth factor-II) is considered to cause non-islet cell tumor hypoglycemia. This paper presents a case of surgically resected retroperitoneal liposarcoma that produced big insulin-like growth factor-II.

CASE PRESENTATION: Here, we report the case of a 62-year-old woman who presented with an abdominal mass and hypoglycemia. Non-islet cell tumor hypoglycemia due to retroperitoneal liposarcoma was suspected. After complete resection of the tumor, the patient's hypoglycemia improved and big insulin-like growth factor-II disappeared in the molecular weight analysis of serum insulin-like growth factor-II by western blotting. The patient had... (More)

BACKGROUND: Tumor-produced high molecular weight insulin-like growth factor-II (big insulin-like growth factor-II) is considered to cause non-islet cell tumor hypoglycemia. This paper presents a case of surgically resected retroperitoneal liposarcoma that produced big insulin-like growth factor-II.

CASE PRESENTATION: Here, we report the case of a 62-year-old woman who presented with an abdominal mass and hypoglycemia. Non-islet cell tumor hypoglycemia due to retroperitoneal liposarcoma was suspected. After complete resection of the tumor, the patient's hypoglycemia improved and big insulin-like growth factor-II disappeared in the molecular weight analysis of serum insulin-like growth factor-II by western blotting. The patient had no tumor recurrence or reappearance of hypoglycemia 16 months after the operation without any adjuvant therapy.

CONCLUSIONS: Although insulin-like growth factor-II-producing tumors are generally large and difficult to operate on, surgical resection is currently the most effective and only treatment; thus, it is essential to attempt resection aggressively.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; and (Less)
publishing date
type
Contribution to journal
publication status
published
subject
in
Surgical case reports
volume
9
article number
19
external identifiers
  • pmid:36752872
ISSN
2198-7793
DOI
10.1186/s40792-023-01589-9
language
English
LU publication?
no
additional info
© 2023. The Author(s).
id
1c26117e-75a9-415d-86dd-664502a2c823
date added to LUP
2025-01-12 01:57:30
date last changed
2025-01-13 08:29:08
@article{1c26117e-75a9-415d-86dd-664502a2c823,
  abstract     = {{<p>BACKGROUND: Tumor-produced high molecular weight insulin-like growth factor-II (big insulin-like growth factor-II) is considered to cause non-islet cell tumor hypoglycemia. This paper presents a case of surgically resected retroperitoneal liposarcoma that produced big insulin-like growth factor-II.</p><p>CASE PRESENTATION: Here, we report the case of a 62-year-old woman who presented with an abdominal mass and hypoglycemia. Non-islet cell tumor hypoglycemia due to retroperitoneal liposarcoma was suspected. After complete resection of the tumor, the patient's hypoglycemia improved and big insulin-like growth factor-II disappeared in the molecular weight analysis of serum insulin-like growth factor-II by western blotting. The patient had no tumor recurrence or reappearance of hypoglycemia 16 months after the operation without any adjuvant therapy.</p><p>CONCLUSIONS: Although insulin-like growth factor-II-producing tumors are generally large and difficult to operate on, surgical resection is currently the most effective and only treatment; thus, it is essential to attempt resection aggressively.</p>}},
  author       = {{Nishiwaki, Noriyuki and Mikuriya, Yoshihiro and Takatsu, Fumiaki and Ochiai, Ryoji and Kakishita, Tomokazu and Kobayashi, Naruyuki and Kobatake, Takaya and Hato, Shinji and Teramoto, Norihiro and Nagao, Mototsugu and Fukuda, Izumi and Ohta, Koji}},
  issn         = {{2198-7793}},
  language     = {{eng}},
  month        = {{02}},
  series       = {{Surgical case reports}},
  title        = {{Surgical resection of a retroperitoneal liposarcoma producing insulin-like growth factor II : a case report}},
  url          = {{http://dx.doi.org/10.1186/s40792-023-01589-9}},
  doi          = {{10.1186/s40792-023-01589-9}},
  volume       = {{9}},
  year         = {{2023}},
}