Twenty-eight-day follow-up of patch test reactions to p-phenylenediamine and p-phenylenediamine dihydrochloride : A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group
(2019) In Contact Dermatitis 81(1). p.1-8- Abstract
Background: There is an ongoing discussion on whether routinely patch testing with p-phenylenediamine (PPD) 1.0% pet. is safe, owing to the risk of patch test sensitization. Late-appearing patch test reactions may reflect patch test sensitization, but may also be attributable to a low degree of pre-existing sensitization. Objectives: To follow the positive patch test reactions to PPD and its salt PPD dihydrochloride (PPD-DHC) in order to characterize reaction patterns concerning time and dose in PPD-sensitized individuals. Methods: Volunteers with previous reactions to PPD 1.0% were included and patch tested with PPD and PPD-DHC in equimolar dilution series. There were then seven follow-up visits over a period of 28 days. Results:... (More)
Background: There is an ongoing discussion on whether routinely patch testing with p-phenylenediamine (PPD) 1.0% pet. is safe, owing to the risk of patch test sensitization. Late-appearing patch test reactions may reflect patch test sensitization, but may also be attributable to a low degree of pre-existing sensitization. Objectives: To follow the positive patch test reactions to PPD and its salt PPD dihydrochloride (PPD-DHC) in order to characterize reaction patterns concerning time and dose in PPD-sensitized individuals. Methods: Volunteers with previous reactions to PPD 1.0% were included and patch tested with PPD and PPD-DHC in equimolar dilution series. There were then seven follow-up visits over a period of 28 days. Results: Twenty-six volunteers completed the study, of whom 23 of 26 (88%) reacted to PPD 1.0%, and 69% reacted to PPD 0.32%. Altogether, 42% and 27% reacted to the corresponding equimolar concentrations of PPD-DHC. After day 7, no new reactions were observed to any concentration tested, either of PPD or of PPD-DHC. Conclusion: No late-appearing reactions to PPD or PPD-DHC were observed at any dose. There is a risk of missing contact allergy when the dose is decreased.
(Less)
- author
- Young, Ewa LU ; Andersen, Klaus E. ; Bruze, Magnus LU ; Giménez-Arnau, Ana ; Ross-Hansen, Katrine ; Johansen, Jeanne D. ; Madsen, Jakob Torp ; Zimerson, Erik LU and Svedman, Cecilia LU
- organization
- publishing date
- 2019-01-26
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- active sensitization, allergic contact dermatitis, contact allergy, delayed, dilution series, false-negative reactions, hypersensitivity, late-appearing patch test reactions, PPD
- in
- Contact Dermatitis
- volume
- 81
- issue
- 1
- pages
- 1 - 8
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:30684277
- scopus:85062965187
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.13235
- language
- English
- LU publication?
- yes
- id
- 1c27a7a5-3f5f-46d5-a146-34b665db3c0c
- date added to LUP
- 2019-03-29 09:24:05
- date last changed
- 2024-07-09 08:39:45
@article{1c27a7a5-3f5f-46d5-a146-34b665db3c0c, abstract = {{<p>Background: There is an ongoing discussion on whether routinely patch testing with p-phenylenediamine (PPD) 1.0% pet. is safe, owing to the risk of patch test sensitization. Late-appearing patch test reactions may reflect patch test sensitization, but may also be attributable to a low degree of pre-existing sensitization. Objectives: To follow the positive patch test reactions to PPD and its salt PPD dihydrochloride (PPD-DHC) in order to characterize reaction patterns concerning time and dose in PPD-sensitized individuals. Methods: Volunteers with previous reactions to PPD 1.0% were included and patch tested with PPD and PPD-DHC in equimolar dilution series. There were then seven follow-up visits over a period of 28 days. Results: Twenty-six volunteers completed the study, of whom 23 of 26 (88%) reacted to PPD 1.0%, and 69% reacted to PPD 0.32%. Altogether, 42% and 27% reacted to the corresponding equimolar concentrations of PPD-DHC. After day 7, no new reactions were observed to any concentration tested, either of PPD or of PPD-DHC. Conclusion: No late-appearing reactions to PPD or PPD-DHC were observed at any dose. There is a risk of missing contact allergy when the dose is decreased.</p>}}, author = {{Young, Ewa and Andersen, Klaus E. and Bruze, Magnus and Giménez-Arnau, Ana and Ross-Hansen, Katrine and Johansen, Jeanne D. and Madsen, Jakob Torp and Zimerson, Erik and Svedman, Cecilia}}, issn = {{0105-1873}}, keywords = {{active sensitization; allergic contact dermatitis; contact allergy; delayed; dilution series; false-negative reactions; hypersensitivity; late-appearing patch test reactions; PPD}}, language = {{eng}}, month = {{01}}, number = {{1}}, pages = {{1--8}}, publisher = {{Wiley-Blackwell}}, series = {{Contact Dermatitis}}, title = {{Twenty-eight-day follow-up of patch test reactions to p-phenylenediamine and p-phenylenediamine dihydrochloride : A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group}}, url = {{http://dx.doi.org/10.1111/cod.13235}}, doi = {{10.1111/cod.13235}}, volume = {{81}}, year = {{2019}}, }