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Twenty-eight-day follow-up of patch test reactions to p-phenylenediamine and p-phenylenediamine dihydrochloride : A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group

Young, Ewa LU ; Andersen, Klaus E.; Bruze, Magnus LU ; Giménez-Arnau, Ana; Ross-Hansen, Katrine; Johansen, Jeanne D.; Madsen, Jakob Torp; Zimerson, Erik LU and Svedman, Cecilia LU (2019) In Contact Dermatitis
Abstract

Background: There is an ongoing discussion on whether routinely patch testing with p-phenylenediamine (PPD) 1.0% pet. is safe, owing to the risk of patch test sensitization. Late-appearing patch test reactions may reflect patch test sensitization, but may also be attributable to a low degree of pre-existing sensitization. Objectives: To follow the positive patch test reactions to PPD and its salt PPD dihydrochloride (PPD-DHC) in order to characterize reaction patterns concerning time and dose in PPD-sensitized individuals. Methods: Volunteers with previous reactions to PPD 1.0% were included and patch tested with PPD and PPD-DHC in equimolar dilution series. There were then seven follow-up visits over a period of 28 days. Results:... (More)

Background: There is an ongoing discussion on whether routinely patch testing with p-phenylenediamine (PPD) 1.0% pet. is safe, owing to the risk of patch test sensitization. Late-appearing patch test reactions may reflect patch test sensitization, but may also be attributable to a low degree of pre-existing sensitization. Objectives: To follow the positive patch test reactions to PPD and its salt PPD dihydrochloride (PPD-DHC) in order to characterize reaction patterns concerning time and dose in PPD-sensitized individuals. Methods: Volunteers with previous reactions to PPD 1.0% were included and patch tested with PPD and PPD-DHC in equimolar dilution series. There were then seven follow-up visits over a period of 28 days. Results: Twenty-six volunteers completed the study, of whom 23 of 26 (88%) reacted to PPD 1.0%, and 69% reacted to PPD 0.32%. Altogether, 42% and 27% reacted to the corresponding equimolar concentrations of PPD-DHC. After day 7, no new reactions were observed to any concentration tested, either of PPD or of PPD-DHC. Conclusion: No late-appearing reactions to PPD or PPD-DHC were observed at any dose. There is a risk of missing contact allergy when the dose is decreased.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
active sensitization, allergic contact dermatitis, contact allergy, delayed, dilution series, false-negative reactions, hypersensitivity, late-appearing patch test reactions, PPD
in
Contact Dermatitis
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • scopus:85062965187
ISSN
0105-1873
DOI
10.1111/cod.13235
language
English
LU publication?
yes
id
1c27a7a5-3f5f-46d5-a146-34b665db3c0c
date added to LUP
2019-03-29 09:24:05
date last changed
2019-04-23 04:47:34
@article{1c27a7a5-3f5f-46d5-a146-34b665db3c0c,
  abstract     = {<p>Background: There is an ongoing discussion on whether routinely patch testing with p-phenylenediamine (PPD) 1.0% pet. is safe, owing to the risk of patch test sensitization. Late-appearing patch test reactions may reflect patch test sensitization, but may also be attributable to a low degree of pre-existing sensitization. Objectives: To follow the positive patch test reactions to PPD and its salt PPD dihydrochloride (PPD-DHC) in order to characterize reaction patterns concerning time and dose in PPD-sensitized individuals. Methods: Volunteers with previous reactions to PPD 1.0% were included and patch tested with PPD and PPD-DHC in equimolar dilution series. There were then seven follow-up visits over a period of 28 days. Results: Twenty-six volunteers completed the study, of whom 23 of 26 (88%) reacted to PPD 1.0%, and 69% reacted to PPD 0.32%. Altogether, 42% and 27% reacted to the corresponding equimolar concentrations of PPD-DHC. After day 7, no new reactions were observed to any concentration tested, either of PPD or of PPD-DHC. Conclusion: No late-appearing reactions to PPD or PPD-DHC were observed at any dose. There is a risk of missing contact allergy when the dose is decreased.</p>},
  author       = {Young, Ewa and Andersen, Klaus E. and Bruze, Magnus and Giménez-Arnau, Ana and Ross-Hansen, Katrine and Johansen, Jeanne D. and Madsen, Jakob Torp and Zimerson, Erik and Svedman, Cecilia},
  issn         = {0105-1873},
  keyword      = {active sensitization,allergic contact dermatitis,contact allergy,delayed,dilution series,false-negative reactions,hypersensitivity,late-appearing patch test reactions,PPD},
  language     = {eng},
  month        = {01},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Twenty-eight-day follow-up of patch test reactions to p-phenylenediamine and p-phenylenediamine dihydrochloride : A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group},
  url          = {http://dx.doi.org/10.1111/cod.13235},
  year         = {2019},
}