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The effect of different strains of Helicobacter pylori on platelet aggregation

Corcoran, Paul A. ; Atherton, John C. ; Kerrigan, Steve W. ; Wadström, Torkel LU ; Murray, Frank E. ; Peek, Richard M. ; Fitzgerald, Desmond J. ; Cox, Dermot M. and Byrne, Michael F. (2007) In Canadian Journal of Gastroenterology 21(6). p.367-370
Abstract
BACKGROUND AND AIMS: Helicobacter pylori is the major causative agent in peptic ulcer disease and is strongly implicated in the development of gastric cancer. It has also been linked, less strongly, to cardiovascular disease. The mechanisms by which certain Strains of H pylon induce platelet aggregation through interactions with platelet glycoprotein 1b have been previously described. METHODS: In the present study, 21 different strains of H pylori, varying in their vacuolating toxin gene, cytotoxic-associated gene A status and other pathogenicity factors, were tested for their ability to induce platelet agggregation. RESULTS: Ten of the 21 strains induced platelet aggregation, a response that appeared to be independent of their vacuolating... (More)
BACKGROUND AND AIMS: Helicobacter pylori is the major causative agent in peptic ulcer disease and is strongly implicated in the development of gastric cancer. It has also been linked, less strongly, to cardiovascular disease. The mechanisms by which certain Strains of H pylon induce platelet aggregation through interactions with platelet glycoprotein 1b have been previously described. METHODS: In the present study, 21 different strains of H pylori, varying in their vacuolating toxin gene, cytotoxic-associated gene A status and other pathogenicity factors, were tested for their ability to induce platelet agggregation. RESULTS: Ten of the 21 strains induced platelet aggregation, a response that appeared to be independent of their vacuolating toxin gene and cytotoxic-associated gene A status. CONCLUSIONS: Platelet aggregation has been suggested to be one of the possible mechanisms involved in the effects on the cardiovascular system induced by H pylori. Our results suggest that any putative role H pylon plays in cardiovascular disease may be strain dependent. Further work to identify the H pylon factors involved in induction of platelet aggregation may allow for identification of 'higher risk' strains for cardiovascular disease. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
platelet aggregation, cardiovascular disease, H pylori
in
Canadian Journal of Gastroenterology
volume
21
issue
6
pages
367 - 370
publisher
Hindawi Limited
external identifiers
  • wos:000247672200005
  • scopus:34547552949
ISSN
0835-7900
language
English
LU publication?
yes
id
1c507c7a-8862-4131-aa2e-9f081b2b83c3 (old id 907740)
date added to LUP
2016-04-01 16:12:47
date last changed
2022-03-14 22:57:36
@article{1c507c7a-8862-4131-aa2e-9f081b2b83c3,
  abstract     = {{BACKGROUND AND AIMS: Helicobacter pylori is the major causative agent in peptic ulcer disease and is strongly implicated in the development of gastric cancer. It has also been linked, less strongly, to cardiovascular disease. The mechanisms by which certain Strains of H pylon induce platelet aggregation through interactions with platelet glycoprotein 1b have been previously described. METHODS: In the present study, 21 different strains of H pylori, varying in their vacuolating toxin gene, cytotoxic-associated gene A status and other pathogenicity factors, were tested for their ability to induce platelet agggregation. RESULTS: Ten of the 21 strains induced platelet aggregation, a response that appeared to be independent of their vacuolating toxin gene and cytotoxic-associated gene A status. CONCLUSIONS: Platelet aggregation has been suggested to be one of the possible mechanisms involved in the effects on the cardiovascular system induced by H pylori. Our results suggest that any putative role H pylon plays in cardiovascular disease may be strain dependent. Further work to identify the H pylon factors involved in induction of platelet aggregation may allow for identification of 'higher risk' strains for cardiovascular disease.}},
  author       = {{Corcoran, Paul A. and Atherton, John C. and Kerrigan, Steve W. and Wadström, Torkel and Murray, Frank E. and Peek, Richard M. and Fitzgerald, Desmond J. and Cox, Dermot M. and Byrne, Michael F.}},
  issn         = {{0835-7900}},
  keywords     = {{platelet aggregation; cardiovascular disease; H pylori}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{367--370}},
  publisher    = {{Hindawi Limited}},
  series       = {{Canadian Journal of Gastroenterology}},
  title        = {{The effect of different strains of Helicobacter pylori on platelet aggregation}},
  volume       = {{21}},
  year         = {{2007}},
}