DTI assessment of the maturing growth plate of the knee in adolescents and young adults
(2023) In European Journal of Radiology 162.- Abstract
Purpose: To assess the growth plates of the knee in a healthy population of young adults and adolescents using DTI, and to correlate the findings with chronological age and skeletal maturation. Methods: A prospective, cross-sectional study to assess the tibial and femoral growth plates with DTI in 155 healthy volunteers aged between 14.0 and 21 years old. Echo-planar DTI with 15 directions and b value of 0 and 600 s/mm2 was performed on a 3 T whole-body scanner. Results: A relationship was observed between chronological age and most DTI metrics (fractional anisotropy, mean diffusivity, and radial diffusivity), tract length and volume. (No significant relationship could be seen for axonal diffusivity and tract length.)... (More)
Purpose: To assess the growth plates of the knee in a healthy population of young adults and adolescents using DTI, and to correlate the findings with chronological age and skeletal maturation. Methods: A prospective, cross-sectional study to assess the tibial and femoral growth plates with DTI in 155 healthy volunteers aged between 14.0 and 21 years old. Echo-planar DTI with 15 directions and b value of 0 and 600 s/mm2 was performed on a 3 T whole-body scanner. Results: A relationship was observed between chronological age and most DTI metrics (fractional anisotropy, mean diffusivity, and radial diffusivity), tract length and volume. (No significant relationship could be seen for axonal diffusivity and tract length.) Subdivision according to skeletal maturation showed the greatest tract lengths and volumes seen in stage 4b and not 4a. The intra-observer agreement was significant (P = 0.01) for all the measured variables, but agreement varied (femur 0.53 – 0.98; tibia 0.58 – 0.98). Spearman's correlation showed a significant correlation for age (P = 0.05; P = 0.01) as well as for the fractional anisotropy value within all variables in both femur and tibia. Tract number and volume had a similar correlation with most variables, especially the DTI metrics, and would seem to be interchangeable. Conclusion: The current study indicates that DTI metrics could be a tool to assess the skeletal maturation process of the growth plate and its activity. Tractography seems promising to assess the activity of the growth plate in a younger population but must be used with caution in the more mature growth plate.
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- author
- Kvist, Ola ; Dorniok, Torsten ; Sanmartin Berglund, Johan ; Nilsson, Ola ; Flodmark, Carl Erik LU and Diaz, Sandra LU
- organization
- publishing date
- 2023-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Diffusion tensor imaging, Growth plate, Magnetic resonance imaging, Maturation process, Puberty
- in
- European Journal of Radiology
- volume
- 162
- article number
- 110759
- publisher
- Elsevier
- external identifiers
-
- pmid:36931119
- scopus:85150174214
- ISSN
- 0720-048X
- DOI
- 10.1016/j.ejrad.2023.110759
- language
- English
- LU publication?
- yes
- id
- 1ca69289-ae42-4bd1-a75e-5d975c477b94
- date added to LUP
- 2023-04-24 11:55:22
- date last changed
- 2024-06-15 02:07:22
@article{1ca69289-ae42-4bd1-a75e-5d975c477b94,
abstract = {{<p>Purpose: To assess the growth plates of the knee in a healthy population of young adults and adolescents using DTI, and to correlate the findings with chronological age and skeletal maturation. Methods: A prospective, cross-sectional study to assess the tibial and femoral growth plates with DTI in 155 healthy volunteers aged between 14.0 and 21 years old. Echo-planar DTI with 15 directions and b value of 0 and 600 s/mm<sup>2</sup> was performed on a 3 T whole-body scanner. Results: A relationship was observed between chronological age and most DTI metrics (fractional anisotropy, mean diffusivity, and radial diffusivity), tract length and volume. (No significant relationship could be seen for axonal diffusivity and tract length.) Subdivision according to skeletal maturation showed the greatest tract lengths and volumes seen in stage 4b and not 4a. The intra-observer agreement was significant (P = 0.01) for all the measured variables, but agreement varied (femur 0.53 – 0.98; tibia 0.58 – 0.98). Spearman's correlation showed a significant correlation for age (P = 0.05; P = 0.01) as well as for the fractional anisotropy value within all variables in both femur and tibia. Tract number and volume had a similar correlation with most variables, especially the DTI metrics, and would seem to be interchangeable. Conclusion: The current study indicates that DTI metrics could be a tool to assess the skeletal maturation process of the growth plate and its activity. Tractography seems promising to assess the activity of the growth plate in a younger population but must be used with caution in the more mature growth plate.</p>}},
author = {{Kvist, Ola and Dorniok, Torsten and Sanmartin Berglund, Johan and Nilsson, Ola and Flodmark, Carl Erik and Diaz, Sandra}},
issn = {{0720-048X}},
keywords = {{Diffusion tensor imaging; Growth plate; Magnetic resonance imaging; Maturation process; Puberty}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{European Journal of Radiology}},
title = {{DTI assessment of the maturing growth plate of the knee in adolescents and young adults}},
url = {{http://dx.doi.org/10.1016/j.ejrad.2023.110759}},
doi = {{10.1016/j.ejrad.2023.110759}},
volume = {{162}},
year = {{2023}},
}