Effects of diet-induced hypercholesterolemia and gold nanoparticles treatment on peripheral tissues
(2022) In Anais da Academia Brasileira de Ciencias 94.- Abstract
Cholesterol is a lipid molecule of great biological importance to animal cells. Dysregulation of cholesterol metabolism leads to raised blood total cholesterol levels, a clinical condition called hypercholesterolemia. Evidence has shown that hypercholesterolemia is associated with the development of liver and heart disease. One of the mechanisms underlying heart and liver alterations induced by hypercholesterolemia is oxidative stress. In this regard, in several experimental studies, gold nanoparticles (AuNP) displayed antioxidant properties. We hypothesized that hypercholesterolemia causes redox system imbalance in the liver and cardiac tissues, and AuNP treatment could ameliorate it. Young adult male Swiss mice fed a regular rodent... (More)
Cholesterol is a lipid molecule of great biological importance to animal cells. Dysregulation of cholesterol metabolism leads to raised blood total cholesterol levels, a clinical condition called hypercholesterolemia. Evidence has shown that hypercholesterolemia is associated with the development of liver and heart disease. One of the mechanisms underlying heart and liver alterations induced by hypercholesterolemia is oxidative stress. In this regard, in several experimental studies, gold nanoparticles (AuNP) displayed antioxidant properties. We hypothesized that hypercholesterolemia causes redox system imbalance in the liver and cardiac tissues, and AuNP treatment could ameliorate it. Young adult male Swiss mice fed a regular rodent diet or a high cholesterol diet for eight weeks and concomitantly treated with AuNP (2.5 μg/kg) or vehicle by oral gavage. Hypercholesterolemia increased the nitrite concentration and glutathione (GSH) levels and decreased the liver’s superoxide dismutase (SOD) activity. Also, hypercholesterolemia significantly enhanced the reactive oxygen species (ROS) and GSH levels in cardiac tissue. Notably, AuNP promoted the redox system homeostasis, increasing the SOD activity in hepatic tissue and reducing ROS levels in cardiac tissue. Overall, our data showed that hypercholesterolemia triggered oxidative stress in mice’s liver and heart, which was partially prevented by AuNP treatment.
(Less)
- author
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Antioxidant molecules, gold nanoparticles, hypercholesterolemia, oxidative stress, peripheral tissues
- in
- Anais da Academia Brasileira de Ciencias
- volume
- 94
- article number
- e20211081
- publisher
- Academia Brasileira de Ciencias
- external identifiers
-
- pmid:36541976
- scopus:85144026338
- ISSN
- 0001-3765
- DOI
- 10.1590/0001-3765202220211081
- language
- English
- LU publication?
- yes
- id
- 1cdbc2e1-3092-4e23-a9dc-17f52bced2f1
- date added to LUP
- 2023-01-12 11:28:06
- date last changed
- 2024-05-30 22:04:18
@article{1cdbc2e1-3092-4e23-a9dc-17f52bced2f1, abstract = {{<p>Cholesterol is a lipid molecule of great biological importance to animal cells. Dysregulation of cholesterol metabolism leads to raised blood total cholesterol levels, a clinical condition called hypercholesterolemia. Evidence has shown that hypercholesterolemia is associated with the development of liver and heart disease. One of the mechanisms underlying heart and liver alterations induced by hypercholesterolemia is oxidative stress. In this regard, in several experimental studies, gold nanoparticles (AuNP) displayed antioxidant properties. We hypothesized that hypercholesterolemia causes redox system imbalance in the liver and cardiac tissues, and AuNP treatment could ameliorate it. Young adult male Swiss mice fed a regular rodent diet or a high cholesterol diet for eight weeks and concomitantly treated with AuNP (2.5 μg/kg) or vehicle by oral gavage. Hypercholesterolemia increased the nitrite concentration and glutathione (GSH) levels and decreased the liver’s superoxide dismutase (SOD) activity. Also, hypercholesterolemia significantly enhanced the reactive oxygen species (ROS) and GSH levels in cardiac tissue. Notably, AuNP promoted the redox system homeostasis, increasing the SOD activity in hepatic tissue and reducing ROS levels in cardiac tissue. Overall, our data showed that hypercholesterolemia triggered oxidative stress in mice’s liver and heart, which was partially prevented by AuNP treatment.</p>}}, author = {{Rodrigues, Matheus S. and Martins, Julia N. and De Paula, Gabriela C. and Venturini, Ligia M. and Silveira, Gustavo De B. and Streck, Emílio L. and Budni, Josiani and De Ávila, Ricardo A.Machado and De Bem, Andreza F. and Silveira, Paulo C.L. and De Oliveira, Jade}}, issn = {{0001-3765}}, keywords = {{Antioxidant molecules; gold nanoparticles; hypercholesterolemia; oxidative stress; peripheral tissues}}, language = {{eng}}, publisher = {{Academia Brasileira de Ciencias}}, series = {{Anais da Academia Brasileira de Ciencias}}, title = {{Effects of diet-induced hypercholesterolemia and gold nanoparticles treatment on peripheral tissues}}, url = {{http://dx.doi.org/10.1590/0001-3765202220211081}}, doi = {{10.1590/0001-3765202220211081}}, volume = {{94}}, year = {{2022}}, }