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Effects of diet-induced hypercholesterolemia and gold nanoparticles treatment on peripheral tissues

Rodrigues, Matheus S. ; Martins, Julia N. ; De Paula, Gabriela C. LU ; Venturini, Ligia M. ; Silveira, Gustavo De B. ; Streck, Emílio L. ; Budni, Josiani ; De Ávila, Ricardo A.Machado ; De Bem, Andreza F. and Silveira, Paulo C.L. , et al. (2022) In Anais da Academia Brasileira de Ciencias 94.
Abstract

Cholesterol is a lipid molecule of great biological importance to animal cells. Dysregulation of cholesterol metabolism leads to raised blood total cholesterol levels, a clinical condition called hypercholesterolemia. Evidence has shown that hypercholesterolemia is associated with the development of liver and heart disease. One of the mechanisms underlying heart and liver alterations induced by hypercholesterolemia is oxidative stress. In this regard, in several experimental studies, gold nanoparticles (AuNP) displayed antioxidant properties. We hypothesized that hypercholesterolemia causes redox system imbalance in the liver and cardiac tissues, and AuNP treatment could ameliorate it. Young adult male Swiss mice fed a regular rodent... (More)

Cholesterol is a lipid molecule of great biological importance to animal cells. Dysregulation of cholesterol metabolism leads to raised blood total cholesterol levels, a clinical condition called hypercholesterolemia. Evidence has shown that hypercholesterolemia is associated with the development of liver and heart disease. One of the mechanisms underlying heart and liver alterations induced by hypercholesterolemia is oxidative stress. In this regard, in several experimental studies, gold nanoparticles (AuNP) displayed antioxidant properties. We hypothesized that hypercholesterolemia causes redox system imbalance in the liver and cardiac tissues, and AuNP treatment could ameliorate it. Young adult male Swiss mice fed a regular rodent diet or a high cholesterol diet for eight weeks and concomitantly treated with AuNP (2.5 μg/kg) or vehicle by oral gavage. Hypercholesterolemia increased the nitrite concentration and glutathione (GSH) levels and decreased the liver’s superoxide dismutase (SOD) activity. Also, hypercholesterolemia significantly enhanced the reactive oxygen species (ROS) and GSH levels in cardiac tissue. Notably, AuNP promoted the redox system homeostasis, increasing the SOD activity in hepatic tissue and reducing ROS levels in cardiac tissue. Overall, our data showed that hypercholesterolemia triggered oxidative stress in mice’s liver and heart, which was partially prevented by AuNP treatment.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antioxidant molecules, gold nanoparticles, hypercholesterolemia, oxidative stress, peripheral tissues
in
Anais da Academia Brasileira de Ciencias
volume
94
article number
e20211081
publisher
Academia Brasileira de Ciencias
external identifiers
  • pmid:36541976
  • scopus:85144026338
ISSN
0001-3765
DOI
10.1590/0001-3765202220211081
language
English
LU publication?
yes
id
1cdbc2e1-3092-4e23-a9dc-17f52bced2f1
date added to LUP
2023-01-12 11:28:06
date last changed
2024-04-04 15:33:33
@article{1cdbc2e1-3092-4e23-a9dc-17f52bced2f1,
  abstract     = {{<p>Cholesterol is a lipid molecule of great biological importance to animal cells. Dysregulation of cholesterol metabolism leads to raised blood total cholesterol levels, a clinical condition called hypercholesterolemia. Evidence has shown that hypercholesterolemia is associated with the development of liver and heart disease. One of the mechanisms underlying heart and liver alterations induced by hypercholesterolemia is oxidative stress. In this regard, in several experimental studies, gold nanoparticles (AuNP) displayed antioxidant properties. We hypothesized that hypercholesterolemia causes redox system imbalance in the liver and cardiac tissues, and AuNP treatment could ameliorate it. Young adult male Swiss mice fed a regular rodent diet or a high cholesterol diet for eight weeks and concomitantly treated with AuNP (2.5 μg/kg) or vehicle by oral gavage. Hypercholesterolemia increased the nitrite concentration and glutathione (GSH) levels and decreased the liver’s superoxide dismutase (SOD) activity. Also, hypercholesterolemia significantly enhanced the reactive oxygen species (ROS) and GSH levels in cardiac tissue. Notably, AuNP promoted the redox system homeostasis, increasing the SOD activity in hepatic tissue and reducing ROS levels in cardiac tissue. Overall, our data showed that hypercholesterolemia triggered oxidative stress in mice’s liver and heart, which was partially prevented by AuNP treatment.</p>}},
  author       = {{Rodrigues, Matheus S. and Martins, Julia N. and De Paula, Gabriela C. and Venturini, Ligia M. and Silveira, Gustavo De B. and Streck, Emílio L. and Budni, Josiani and De Ávila, Ricardo A.Machado and De Bem, Andreza F. and Silveira, Paulo C.L. and De Oliveira, Jade}},
  issn         = {{0001-3765}},
  keywords     = {{Antioxidant molecules; gold nanoparticles; hypercholesterolemia; oxidative stress; peripheral tissues}},
  language     = {{eng}},
  publisher    = {{Academia Brasileira de Ciencias}},
  series       = {{Anais da Academia Brasileira de Ciencias}},
  title        = {{Effects of diet-induced hypercholesterolemia and gold nanoparticles treatment on peripheral tissues}},
  url          = {{http://dx.doi.org/10.1590/0001-3765202220211081}},
  doi          = {{10.1590/0001-3765202220211081}},
  volume       = {{94}},
  year         = {{2022}},
}