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Detection Performance and Risk Stratification Using a Model-Based Shape Index Characterizing Heart Rate Turbulence

Pablo Martinez, Juan ; Cygankiewicz, Iwona ; Smith, Danny LU ; Bayes de Luna, Antonio ; Laguna, Pablo and Sörnmo, Leif LU (2010) In Annals of Biomedical Engineering 38(10). p.3173-3184
Abstract
A detection-theoretic approach to quantify heart rate turbulence (HRT) following a ventricular premature beat is proposed and validated using an extended integral pulse frequency modulation (IPFM) model which accounts for HRT. The modulating signal of the extended IPFM model is projected into a three-dimensional subspace spanned by the Karhunen-Loeve basis functions, characterizing HRT shape. The presence or absence of HRT is decided by means of a likelihood ratio test, the Neyman-Pearson detector, resulting in a quadratic detection statistic. Using a labeled dataset built from different interbeat interval series, detection performance is assessed and found to outperform the two widely used indices: turbulence onset (TO) and turbulence... (More)
A detection-theoretic approach to quantify heart rate turbulence (HRT) following a ventricular premature beat is proposed and validated using an extended integral pulse frequency modulation (IPFM) model which accounts for HRT. The modulating signal of the extended IPFM model is projected into a three-dimensional subspace spanned by the Karhunen-Loeve basis functions, characterizing HRT shape. The presence or absence of HRT is decided by means of a likelihood ratio test, the Neyman-Pearson detector, resulting in a quadratic detection statistic. Using a labeled dataset built from different interbeat interval series, detection performance is assessed and found to outperform the two widely used indices: turbulence onset (TO) and turbulence slope (TS). The ability of the proposed method to predict the risk of cardiac death is evaluated in a population of patients (n = 90) with ischemic cardiomyopathy and mild-to-moderate congestive heart failure. While both TS and the novel HRT index differ significantly in survivors and cardiac death patients, mortality analysis shows that the latter index exhibits much stronger association with risk of cardiac death (hazard ratio = 2.8, CI = 1.32-5.97, p = 0.008). It is also shown that the model-based shape indices, but not TO and TS, remain predictive of cardiac death in our population when computed from 4-h instead of 24-h ambulatory ECGs. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
stratification, Risk, Mortality analysis, Detection theory, Karhunen-Loeve transform, Likelihood ratio test, Heart rate turbulence, Neyman-Pearson detection, Congestive heart failure, Ischemic cardiomyopathy
in
Annals of Biomedical Engineering
volume
38
issue
10
pages
3173 - 3184
publisher
Springer
external identifiers
  • wos:000281895500012
  • scopus:77956785121
  • pmid:20517647
ISSN
1573-9686
DOI
10.1007/s10439-010-0081-8
language
English
LU publication?
yes
id
1d06f520-2fed-44fe-91d3-01508bbb0ad5 (old id 1695692)
date added to LUP
2016-04-01 10:33:50
date last changed
2022-01-26 00:28:13
@article{1d06f520-2fed-44fe-91d3-01508bbb0ad5,
  abstract     = {{A detection-theoretic approach to quantify heart rate turbulence (HRT) following a ventricular premature beat is proposed and validated using an extended integral pulse frequency modulation (IPFM) model which accounts for HRT. The modulating signal of the extended IPFM model is projected into a three-dimensional subspace spanned by the Karhunen-Loeve basis functions, characterizing HRT shape. The presence or absence of HRT is decided by means of a likelihood ratio test, the Neyman-Pearson detector, resulting in a quadratic detection statistic. Using a labeled dataset built from different interbeat interval series, detection performance is assessed and found to outperform the two widely used indices: turbulence onset (TO) and turbulence slope (TS). The ability of the proposed method to predict the risk of cardiac death is evaluated in a population of patients (n = 90) with ischemic cardiomyopathy and mild-to-moderate congestive heart failure. While both TS and the novel HRT index differ significantly in survivors and cardiac death patients, mortality analysis shows that the latter index exhibits much stronger association with risk of cardiac death (hazard ratio = 2.8, CI = 1.32-5.97, p = 0.008). It is also shown that the model-based shape indices, but not TO and TS, remain predictive of cardiac death in our population when computed from 4-h instead of 24-h ambulatory ECGs.}},
  author       = {{Pablo Martinez, Juan and Cygankiewicz, Iwona and Smith, Danny and Bayes de Luna, Antonio and Laguna, Pablo and Sörnmo, Leif}},
  issn         = {{1573-9686}},
  keywords     = {{stratification; Risk; Mortality analysis; Detection theory; Karhunen-Loeve transform; Likelihood ratio test; Heart rate turbulence; Neyman-Pearson detection; Congestive heart failure; Ischemic cardiomyopathy}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{3173--3184}},
  publisher    = {{Springer}},
  series       = {{Annals of Biomedical Engineering}},
  title        = {{Detection Performance and Risk Stratification Using a Model-Based Shape Index Characterizing Heart Rate Turbulence}},
  url          = {{http://dx.doi.org/10.1007/s10439-010-0081-8}},
  doi          = {{10.1007/s10439-010-0081-8}},
  volume       = {{38}},
  year         = {{2010}},
}