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Quality of Life in the First Year of Follow-Up in a Randomized Multicenter Trial Assessing the Role of Imaging after Radical Surgery of Stage IIB-C and III Cutaneous Melanoma (TRIM Study)

Naeser, Ylva ; Helgadottir, Hildur ; Hansson, Johan ; Ingvar, Christian LU ; Elander, Nils O. ; Flygare, Petra ; Nilsson, Cecilia ; Jakobsson, Frida ; Valachis, Antonios and Papantoniou, Dimitrios , et al. (2022) In Cancers 14(4).
Abstract

The benefit of imaging in the follow-up setting for high-risk melanoma patients is uncertain, and even less is known about the impact of intensive follow-up on the patient´s quality of life. In 2017, a Swedish prospective randomized multicenter study started, in which high-risk melanoma patients are randomly assigned 1:1 to follow-up by physical examinations +/− whole-body imaging. The first-year examinations are scheduled at 0, 6 and 12 months. The aim of this study was to investigate whether the patients´ health-related quality of life (HRQoL) and levels of anxiety and depression were affected at 1 year by imaging. Anxiety/depression and HRQoL were assessed at 0 and 12 months by the questionnaires Hospital Anxiety and Depression (HAD)... (More)

The benefit of imaging in the follow-up setting for high-risk melanoma patients is uncertain, and even less is known about the impact of intensive follow-up on the patient´s quality of life. In 2017, a Swedish prospective randomized multicenter study started, in which high-risk melanoma patients are randomly assigned 1:1 to follow-up by physical examinations +/− whole-body imaging. The first-year examinations are scheduled at 0, 6 and 12 months. The aim of this study was to investigate whether the patients´ health-related quality of life (HRQoL) and levels of anxiety and depression were affected at 1 year by imaging. Anxiety/depression and HRQoL were assessed at 0 and 12 months by the questionnaires Hospital Anxiety and Depression (HAD) scale and EORTC QLQ-C30 version 3. Expected baseline QLQ-C30 values for the patients were calculated using data from the general population. In total, 204 patients were analyzed. Mean differences in subscale scores at 1 year were not statistically significant either for HRQoL or for anxiety/depression. Baseline HRQoL did not differ from expected values in the general Swedish population. In conclusion, the patients in general coped well with the situation, and adding whole-body imaging to physical examinations did not affect the melanoma patients’ HRQoL or levels of anxiety or depression.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Follow-up studies, Melanoma, Positron emission tomography computed tomography, Prospective studies, Quality of life, Randomized controlled trial, Tomography, X-ray computed
in
Cancers
volume
14
issue
4
article number
1040
publisher
MDPI AG
external identifiers
  • pmid:35205786
  • scopus:85124989637
ISSN
2072-6694
DOI
10.3390/cancers14041040
language
English
LU publication?
yes
id
1d33c99a-fde9-4df1-984d-07a344a8984e
date added to LUP
2022-04-13 10:45:49
date last changed
2024-06-18 15:48:45
@article{1d33c99a-fde9-4df1-984d-07a344a8984e,
  abstract     = {{<p>The benefit of imaging in the follow-up setting for high-risk melanoma patients is uncertain, and even less is known about the impact of intensive follow-up on the patient´s quality of life. In 2017, a Swedish prospective randomized multicenter study started, in which high-risk melanoma patients are randomly assigned 1:1 to follow-up by physical examinations +/− whole-body imaging. The first-year examinations are scheduled at 0, 6 and 12 months. The aim of this study was to investigate whether the patients´ health-related quality of life (HRQoL) and levels of anxiety and depression were affected at 1 year by imaging. Anxiety/depression and HRQoL were assessed at 0 and 12 months by the questionnaires Hospital Anxiety and Depression (HAD) scale and EORTC QLQ-C30 version 3. Expected baseline QLQ-C30 values for the patients were calculated using data from the general population. In total, 204 patients were analyzed. Mean differences in subscale scores at 1 year were not statistically significant either for HRQoL or for anxiety/depression. Baseline HRQoL did not differ from expected values in the general Swedish population. In conclusion, the patients in general coped well with the situation, and adding whole-body imaging to physical examinations did not affect the melanoma patients’ HRQoL or levels of anxiety or depression.</p>}},
  author       = {{Naeser, Ylva and Helgadottir, Hildur and Hansson, Johan and Ingvar, Christian and Elander, Nils O. and Flygare, Petra and Nilsson, Cecilia and Jakobsson, Frida and Valachis, Antonios and Papantoniou, Dimitrios and Danfors, Agneta Nordin and Johansson, Hemming and Sundin, Anders and Brandberg, Yvonne and Ullenhag, Gustav J.}},
  issn         = {{2072-6694}},
  keywords     = {{Follow-up studies; Melanoma; Positron emission tomography computed tomography; Prospective studies; Quality of life; Randomized controlled trial; Tomography; X-ray computed}},
  language     = {{eng}},
  number       = {{4}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{Quality of Life in the First Year of Follow-Up in a Randomized Multicenter Trial Assessing the Role of Imaging after Radical Surgery of Stage IIB-C and III Cutaneous Melanoma (TRIM Study)}},
  url          = {{http://dx.doi.org/10.3390/cancers14041040}},
  doi          = {{10.3390/cancers14041040}},
  volume       = {{14}},
  year         = {{2022}},
}