First two decades of paediatric heart transplantation in Sweden - outcome of listing and post-transplant results.
(2011) In Acta Pædiatrica 100(11). p.1442-1447- Abstract
- Aims: To evaluate outcome in the first generation of children with end-stage heart disease to whom heart transplantation was available. Methods: Retrospective review of all 135 Swedish children <18 years old listed for heart transplantation 1989-2009, followed to December 31, 2009, including 74 (55%) with cardiomyopathy and 61 (45%) with congenital heart disease; 34 (25%) were infants (<1 year). Cumulative risk of requiring heart transplantation was 1:17 300 (11 patients who improved were omitted from outcome analysis). Results: Waiting-list mortality was 31% (44% in infants). Median waiting time in 82 transplanted patients was 57 days (0-585 days). Post-transplant follow-up time was median 5.9 years (0.03-20.1 years), and... (More)
- Aims: To evaluate outcome in the first generation of children with end-stage heart disease to whom heart transplantation was available. Methods: Retrospective review of all 135 Swedish children <18 years old listed for heart transplantation 1989-2009, followed to December 31, 2009, including 74 (55%) with cardiomyopathy and 61 (45%) with congenital heart disease; 34 (25%) were infants (<1 year). Cumulative risk of requiring heart transplantation was 1:17 300 (11 patients who improved were omitted from outcome analysis). Results: Waiting-list mortality was 31% (44% in infants). Median waiting time in 82 transplanted patients was 57 days (0-585 days). Post-transplant follow-up time was median 5.9 years (0.03-20.1 years), and actuarial survival was 92% at 1 year, 82% at 5 years, 76% at 10 years and 58% at 15 years. Survival after listing was 64% at 1 year, 58% at 5 years, 52% at 10 years and 40% at 15 years. Post-transplant complications included rejections (34%), malignancies (12%), renal failure (8%), coronary artery vasculopathy (6%) and re-transplantation (5%). Among 64 survivors, 84% were free of complications affecting prognosis. Conclusion: High waiting-list mortality and post-transplant attrition precluded 60% of this pioneer population from reaching adulthood. Functional status in survivors is generally good. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2008437
- author
- Gilljam, Thomas ; Higgins, Thomas ; Bennhagen, Rolf LU and Wåhlander, Håkan
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Complications, Heart transplantation, Paediatric cardiology, Survival
- in
- Acta Pædiatrica
- volume
- 100
- issue
- 11
- pages
- 1442 - 1447
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000296421300019
- pmid:21645110
- scopus:80054019469
- pmid:21645110
- ISSN
- 1651-2227
- DOI
- 10.1111/j.1651-2227.2011.02377.x
- language
- English
- LU publication?
- yes
- id
- 1d681a1b-15e7-456a-9fdf-f6deaabe7772 (old id 2008437)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21645110?dopt=Abstract
- date added to LUP
- 2016-04-01 10:58:34
- date last changed
- 2022-01-26 04:20:14
@article{1d681a1b-15e7-456a-9fdf-f6deaabe7772,
abstract = {{Aims: To evaluate outcome in the first generation of children with end-stage heart disease to whom heart transplantation was available. Methods: Retrospective review of all 135 Swedish children <18 years old listed for heart transplantation 1989-2009, followed to December 31, 2009, including 74 (55%) with cardiomyopathy and 61 (45%) with congenital heart disease; 34 (25%) were infants (<1 year). Cumulative risk of requiring heart transplantation was 1:17 300 (11 patients who improved were omitted from outcome analysis). Results: Waiting-list mortality was 31% (44% in infants). Median waiting time in 82 transplanted patients was 57 days (0-585 days). Post-transplant follow-up time was median 5.9 years (0.03-20.1 years), and actuarial survival was 92% at 1 year, 82% at 5 years, 76% at 10 years and 58% at 15 years. Survival after listing was 64% at 1 year, 58% at 5 years, 52% at 10 years and 40% at 15 years. Post-transplant complications included rejections (34%), malignancies (12%), renal failure (8%), coronary artery vasculopathy (6%) and re-transplantation (5%). Among 64 survivors, 84% were free of complications affecting prognosis. Conclusion: High waiting-list mortality and post-transplant attrition precluded 60% of this pioneer population from reaching adulthood. Functional status in survivors is generally good.}},
author = {{Gilljam, Thomas and Higgins, Thomas and Bennhagen, Rolf and Wåhlander, Håkan}},
issn = {{1651-2227}},
keywords = {{Complications; Heart transplantation; Paediatric cardiology; Survival}},
language = {{eng}},
number = {{11}},
pages = {{1442--1447}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Pædiatrica}},
title = {{First two decades of paediatric heart transplantation in Sweden - outcome of listing and post-transplant results.}},
url = {{http://dx.doi.org/10.1111/j.1651-2227.2011.02377.x}},
doi = {{10.1111/j.1651-2227.2011.02377.x}},
volume = {{100}},
year = {{2011}},
}