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Impact of month of birth on the development of autoimmune thyroid disease in the United Kingdom and Europe

Hamilton, Alexander LU ; Newby, Paul R ; Carr-Smith, Jacqueline D ; Disanto, Giulio ; Allahabadia, Amit ; Armitage, Mary ; Brix, Thomas H ; Chatterjee, Krishna ; Connell, John M and Hegedüs, Laszlo , et al. (2014) In The Journal of clinical endocrinology and metabolism 99(8). p.65-1459
Abstract

CONTEXT: Viral/bacterial infection is proposed as a trigger for the autoimmune thyroid diseases (AITD): Graves' disease (GD) and Hashimoto's thyroiditis (HT). Previous studies in European Caucasian AITD subjects found higher birth rates in the autumn/winter, suggesting those born in the autumn/winter experience increased viral/bacterial exposure after birth, impacting upon immune system development and predisposing to AITD later in life.

OBJECTIVE: Month of birth effects were investigated in three independent European Caucasian AITD datasets.

DESIGN: Variation in GD and HT onset was compared across months and seasons, with fluctuations across all 12 months analyzed using a Walter-Elwood test.

SETTING: The study was... (More)

CONTEXT: Viral/bacterial infection is proposed as a trigger for the autoimmune thyroid diseases (AITD): Graves' disease (GD) and Hashimoto's thyroiditis (HT). Previous studies in European Caucasian AITD subjects found higher birth rates in the autumn/winter, suggesting those born in the autumn/winter experience increased viral/bacterial exposure after birth, impacting upon immune system development and predisposing to AITD later in life.

OBJECTIVE: Month of birth effects were investigated in three independent European Caucasian AITD datasets.

DESIGN: Variation in GD and HT onset was compared across months and seasons, with fluctuations across all 12 months analyzed using a Walter-Elwood test.

SETTING: The study was conducted at a research laboratory.

PATIENTS: National UK Caucasian AITD Case Control Collection (2746 GD and 502 HT compared with 1 423 716 UK births), National UK Caucasian GD Family Collection (239 GD and 227 unaffected siblings), and OXAGEN AITD Caucasian Family Collection (885 GD, 717 HT, and 794 unaffected siblings of European Caucasian decent).

MAIN OUTCOME MEASURES: Case-control and family-based association studies were measured.

RESULTS: No consistent month of birth effects were detected in GD females or males across all three collections. In HT females from the OXAGEN AITD Caucasian Family Collection, slightly higher birth rates were detected in autumn (Walter's test statistic = 7.47, P = .024) however, this was not seen in the HT females from the case-control cohort.

CONCLUSION: Our results suggest in UK/Northern European Caucasian GD subjects, month of birth does not impact on AITD development. Although some month of birth effects for HT females in one collection cannot be excluded, only further work in larger European Caucasian AITD collections can confirm these effects.

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@article{1d7c37fa-bb6f-4ceb-bc91-83612d5f5ce6,
  abstract     = {<p>CONTEXT: Viral/bacterial infection is proposed as a trigger for the autoimmune thyroid diseases (AITD): Graves' disease (GD) and Hashimoto's thyroiditis (HT). Previous studies in European Caucasian AITD subjects found higher birth rates in the autumn/winter, suggesting those born in the autumn/winter experience increased viral/bacterial exposure after birth, impacting upon immune system development and predisposing to AITD later in life.</p><p>OBJECTIVE: Month of birth effects were investigated in three independent European Caucasian AITD datasets.</p><p>DESIGN: Variation in GD and HT onset was compared across months and seasons, with fluctuations across all 12 months analyzed using a Walter-Elwood test.</p><p>SETTING: The study was conducted at a research laboratory.</p><p>PATIENTS: National UK Caucasian AITD Case Control Collection (2746 GD and 502 HT compared with 1 423 716 UK births), National UK Caucasian GD Family Collection (239 GD and 227 unaffected siblings), and OXAGEN AITD Caucasian Family Collection (885 GD, 717 HT, and 794 unaffected siblings of European Caucasian decent).</p><p>MAIN OUTCOME MEASURES: Case-control and family-based association studies were measured.</p><p>RESULTS: No consistent month of birth effects were detected in GD females or males across all three collections. In HT females from the OXAGEN AITD Caucasian Family Collection, slightly higher birth rates were detected in autumn (Walter's test statistic = 7.47, P = .024) however, this was not seen in the HT females from the case-control cohort.</p><p>CONCLUSION: Our results suggest in UK/Northern European Caucasian GD subjects, month of birth does not impact on AITD development. Although some month of birth effects for HT females in one collection cannot be excluded, only further work in larger European Caucasian AITD collections can confirm these effects.</p>},
  author       = {Hamilton, Alexander and Newby, Paul R and Carr-Smith, Jacqueline D and Disanto, Giulio and Allahabadia, Amit and Armitage, Mary and Brix, Thomas H and Chatterjee, Krishna and Connell, John M and Hegedüs, Laszlo and Hunt, Penny J and Lazarus, John H and Pearce, Simon H and Robinson, Bruce G and Taylor, Jenny C and Vaidya, Bijay and Wass, John A H and Wiersinga, Wilmar M and Weetman, Anthony P and Ramagopalan, Sreeram V and Franklyn, Jayne A and Gough, Stephen C L and Simmonds, Matthew J},
  issn         = {1945-7197},
  language     = {eng},
  number       = {8},
  pages        = {65--1459},
  publisher    = {The Endocrine Society},
  series       = {The Journal of clinical endocrinology and metabolism},
  title        = {Impact of month of birth on the development of autoimmune thyroid disease in the United Kingdom and Europe},
  url          = {http://dx.doi.org/10.1210/jc.2014-1270},
  doi          = {10.1210/jc.2014-1270},
  volume       = {99},
  year         = {2014},
}