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Adipose tissue concentrations of dioxins and dibenzofurans in patients with malignant lymphoproliferative diseases and in patients without a malignant disease

Hardell, L. ; Fredrikson, M. ; Eriksson, M. LU orcid ; Hansson, M. and Rappe, C. (1995) In European Journal of Cancer Prevention 4(3). p.225-230
Abstract

Concentrations of dioxins (PCDD) and dibenzofurans (PCDF) were analysed in adipose tissue from seven patients with malignant lymphoproliferative diseases and 12 surgical patients without a malignant disease. All cases in the first group had reported potential exposure to PCDD and PCDF. Of the analysed congeners significantly higher concentrations of 1, 2, 3, 7, 8-pentachlorodioxin, 1, 2, 3, 6, 7, 8-hexachlorodioxin, and 2, 3, 4, 7, 8-pentachlorodibenzofuran were found in the cases with lymphoproliferative diseases compared with the patients in the other group. Higher mean concentration of 2, 3, 7, 8-TCDD was also found in the first group but not significantly so. Toxic equivalents of PCDD and PCDF were significantly higher in the first... (More)

Concentrations of dioxins (PCDD) and dibenzofurans (PCDF) were analysed in adipose tissue from seven patients with malignant lymphoproliferative diseases and 12 surgical patients without a malignant disease. All cases in the first group had reported potential exposure to PCDD and PCDF. Of the analysed congeners significantly higher concentrations of 1, 2, 3, 7, 8-pentachlorodioxin, 1, 2, 3, 6, 7, 8-hexachlorodioxin, and 2, 3, 4, 7, 8-pentachlorodibenzofuran were found in the cases with lymphoproliferative diseases compared with the patients in the other group. Higher mean concentration of 2, 3, 7, 8-TCDD was also found in the first group but not significantly so. Toxic equivalents of PCDD and PCDF were significantly higher in the first group (mean 64.7 pg/g, range 19.9-187) than in the second group (mean 29.7 pg/g, range 12.9-53.4). Even if the cases with lymphoproliferative diseases in this case series were potentially exposed to PCDD/PCDF in contrast to the other group, the observed differences may be of interest in relation to the aetiology of these malignancies. Immunosuppression increases the risk for malignant lymphoproliferative diseases, and PCDD/PCDF have established immunotoxic properties.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dibenzofurans, dioxins, malignant lymphoproliferative diseases
in
European Journal of Cancer Prevention
volume
4
issue
3
pages
225 - 230
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:0029024282
  • pmid:7647690
ISSN
0959-8278
DOI
10.1097/00008469-199506000-00003
language
English
LU publication?
no
id
1d809010-79aa-41df-adb7-5d716689bf35
date added to LUP
2020-02-18 17:22:30
date last changed
2024-01-02 05:47:30
@article{1d809010-79aa-41df-adb7-5d716689bf35,
  abstract     = {{<p>Concentrations of dioxins (PCDD) and dibenzofurans (PCDF) were analysed in adipose tissue from seven patients with malignant lymphoproliferative diseases and 12 surgical patients without a malignant disease. All cases in the first group had reported potential exposure to PCDD and PCDF. Of the analysed congeners significantly higher concentrations of 1, 2, 3, 7, 8-pentachlorodioxin, 1, 2, 3, 6, 7, 8-hexachlorodioxin, and 2, 3, 4, 7, 8-pentachlorodibenzofuran were found in the cases with lymphoproliferative diseases compared with the patients in the other group. Higher mean concentration of 2, 3, 7, 8-TCDD was also found in the first group but not significantly so. Toxic equivalents of PCDD and PCDF were significantly higher in the first group (mean 64.7 pg/g, range 19.9-187) than in the second group (mean 29.7 pg/g, range 12.9-53.4). Even if the cases with lymphoproliferative diseases in this case series were potentially exposed to PCDD/PCDF in contrast to the other group, the observed differences may be of interest in relation to the aetiology of these malignancies. Immunosuppression increases the risk for malignant lymphoproliferative diseases, and PCDD/PCDF have established immunotoxic properties.</p>}},
  author       = {{Hardell, L. and Fredrikson, M. and Eriksson, M. and Hansson, M. and Rappe, C.}},
  issn         = {{0959-8278}},
  keywords     = {{Dibenzofurans; dioxins; malignant lymphoproliferative diseases}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{3}},
  pages        = {{225--230}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{European Journal of Cancer Prevention}},
  title        = {{Adipose tissue concentrations of dioxins and dibenzofurans in patients with malignant lymphoproliferative diseases and in patients without a malignant disease}},
  url          = {{http://dx.doi.org/10.1097/00008469-199506000-00003}},
  doi          = {{10.1097/00008469-199506000-00003}},
  volume       = {{4}},
  year         = {{1995}},
}