Cardiac q-space trajectory imaging by motion-compensated tensor-valued diffusion encoding in human heart in vivo
(2023) In Magnetic Resonance in Medicine 90(1). p.150-165- Abstract
Purpose: Tensor-valued diffusion encoding can probe more specific features of tissue microstructure than what is available by conventional diffusion weighting. In this work, we investigate the technical feasibility of tensor-valued diffusion encoding at high b-values with q-space trajectory imaging (QTI) analysis, in the human heart in vivo. Methods: Ten healthy volunteers were scanned on a 3T scanner. We designed time-optimal gradient waveforms for tensor-valued diffusion encoding (linear and planar) with second-order motion compensation. Data were analyzed with QTI. Normal values and repeatability were investigated for the mean diffusivity (MD), fractional anisotropy (FA), microscopic FA (μFA), isotropic, anisotropic and total mean... (More)
Purpose: Tensor-valued diffusion encoding can probe more specific features of tissue microstructure than what is available by conventional diffusion weighting. In this work, we investigate the technical feasibility of tensor-valued diffusion encoding at high b-values with q-space trajectory imaging (QTI) analysis, in the human heart in vivo. Methods: Ten healthy volunteers were scanned on a 3T scanner. We designed time-optimal gradient waveforms for tensor-valued diffusion encoding (linear and planar) with second-order motion compensation. Data were analyzed with QTI. Normal values and repeatability were investigated for the mean diffusivity (MD), fractional anisotropy (FA), microscopic FA (μFA), isotropic, anisotropic and total mean kurtosis (MKi, MKa, and MKt), and orientation coherence (Cc). A phantom, consisting of two fiber blocks at adjustable angles, was used to evaluate sensitivity of parameters to orientation dispersion and diffusion time. Results: QTI data in the left ventricular myocardium were MD = 1.62 ± 0.07 μm2/ms, FA = 0.31 ± 0.03, μFA = 0.43 ± 0.07, MKa = 0.20 ± 0.07, MKi = 0.13 ± 0.03, MKt = 0.33 ± 0.09, and Cc = 0.56 ± 0.22 (mean ± SD across subjects). Phantom experiments showed that FA depends on orientation dispersion, whereas μFA was insensitive to this effect. Conclusion: We demonstrated the first tensor-valued diffusion encoding and QTI analysis in the heart in vivo, along with first measurements of myocardial μFA, MKi, MKa, and Cc. The methodology is technically feasible and provides promising novel biomarkers for myocardial tissue characterization.
(Less)
- author
- Teh, Irvin
; Shelley, David
; Boyle, Jordan H.
; Zhou, Fenglei
; Poenar, Ana Maria
; Sharrack, Noor
; Foster, Richard J.
; Yuldasheva, Nadira Y.
; Parker, Geoff J.M.
; Dall'Armellina, Erica
; Plein, Sven
; Schneider, Jürgen E.
and Szczepankiewicz, Filip
LU
(Less) - organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cardiac microstructure, diffusion tensor imaging, motion-compensated diffusion encoding, q-space trajectory imaging, tensor-valued diffusion encoding, tissue characterization
- in
- Magnetic Resonance in Medicine
- volume
- 90
- issue
- 1
- pages
- 16 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:36941736
- scopus:85150904901
- ISSN
- 0740-3194
- DOI
- 10.1002/mrm.29637
- language
- English
- LU publication?
- yes
- id
- 1dbf435a-e3e3-4c28-b172-45f41e25d7b9
- date added to LUP
- 2023-05-26 13:13:59
- date last changed
- 2024-06-15 03:25:28
@article{1dbf435a-e3e3-4c28-b172-45f41e25d7b9,
abstract = {{<p>Purpose: Tensor-valued diffusion encoding can probe more specific features of tissue microstructure than what is available by conventional diffusion weighting. In this work, we investigate the technical feasibility of tensor-valued diffusion encoding at high b-values with q-space trajectory imaging (QTI) analysis, in the human heart in vivo. Methods: Ten healthy volunteers were scanned on a 3T scanner. We designed time-optimal gradient waveforms for tensor-valued diffusion encoding (linear and planar) with second-order motion compensation. Data were analyzed with QTI. Normal values and repeatability were investigated for the mean diffusivity (MD), fractional anisotropy (FA), microscopic FA (μFA), isotropic, anisotropic and total mean kurtosis (MKi, MKa, and MKt), and orientation coherence (C<sub>c</sub>). A phantom, consisting of two fiber blocks at adjustable angles, was used to evaluate sensitivity of parameters to orientation dispersion and diffusion time. Results: QTI data in the left ventricular myocardium were MD = 1.62 ± 0.07 μm<sup>2</sup>/ms, FA = 0.31 ± 0.03, μFA = 0.43 ± 0.07, MKa = 0.20 ± 0.07, MKi = 0.13 ± 0.03, MKt = 0.33 ± 0.09, and C<sub>c</sub> = 0.56 ± 0.22 (mean ± SD across subjects). Phantom experiments showed that FA depends on orientation dispersion, whereas μFA was insensitive to this effect. Conclusion: We demonstrated the first tensor-valued diffusion encoding and QTI analysis in the heart in vivo, along with first measurements of myocardial μFA, MKi, MKa, and C<sub>c</sub>. The methodology is technically feasible and provides promising novel biomarkers for myocardial tissue characterization.</p>}},
author = {{Teh, Irvin and Shelley, David and Boyle, Jordan H. and Zhou, Fenglei and Poenar, Ana Maria and Sharrack, Noor and Foster, Richard J. and Yuldasheva, Nadira Y. and Parker, Geoff J.M. and Dall'Armellina, Erica and Plein, Sven and Schneider, Jürgen E. and Szczepankiewicz, Filip}},
issn = {{0740-3194}},
keywords = {{cardiac microstructure; diffusion tensor imaging; motion-compensated diffusion encoding; q-space trajectory imaging; tensor-valued diffusion encoding; tissue characterization}},
language = {{eng}},
number = {{1}},
pages = {{150--165}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Magnetic Resonance in Medicine}},
title = {{Cardiac q-space trajectory imaging by motion-compensated tensor-valued diffusion encoding in human heart in vivo}},
url = {{http://dx.doi.org/10.1002/mrm.29637}},
doi = {{10.1002/mrm.29637}},
volume = {{90}},
year = {{2023}},
}