Clinical Manifestations and Outcomes in Adults Hospitalized With Respiratory Syncytial Virus and Influenza a/B : A Multicenter Observational Cohort Study
(2024) In Open Forum Infectious Diseases 11(10).- Abstract
BACKGROUND: Respiratory syncytial virus (RSV) and influenza cause significant health challenges, particularly for individuals with comorbid conditions and older adults. However, information on the clinical manifestations and outcomes of adults hospitalized with RSV in Europe remains limited.
METHODS: This multicenter observational cohort study of adults hospitalized with RSV or influenza A or B from March 2016 to April 2020 investigated the clinical manifestations, mortality risk factors, and association with 90-day mortality rates by logistic regression analysis after adjustment for covariates.
RESULTS: Of 988 patients hospitalized with either virus, 353 had RSV, 347 had influenza A, and 288 had influenza B infection.... (More)
BACKGROUND: Respiratory syncytial virus (RSV) and influenza cause significant health challenges, particularly for individuals with comorbid conditions and older adults. However, information on the clinical manifestations and outcomes of adults hospitalized with RSV in Europe remains limited.
METHODS: This multicenter observational cohort study of adults hospitalized with RSV or influenza A or B from March 2016 to April 2020 investigated the clinical manifestations, mortality risk factors, and association with 90-day mortality rates by logistic regression analysis after adjustment for covariates.
RESULTS: Of 988 patients hospitalized with either virus, 353 had RSV, 347 had influenza A, and 288 had influenza B infection. Patients with RSV, compared with those with influenza A or B, were more likely to have comorbid conditions (83% for RSV vs 72% for influenza A [P = .03] and 74% for influenza B [P = .001]) or pneumonia (41% vs 29% [P = .03] and 24% [P < .001], respectively). After adjustment for covariates, RSV infection was associated with an increased all-cause mortality rate within 90 days compared with influenza B (odds ratio, 2.16 [95% confidence interval, 1.20-3.87]; P = .01) but not influenza A (1.38 [.84-2.29]; P = .21). Increasing age and present pneumonia were identified as independent mortality risk factors in patients with RSV.
CONCLUSIONS: Older adults hospitalized with RSV infections are at a higher risk of dying within 90 days of hospitalization than patients admitted with influenza B but at a similar risk as those admitted with influenza A, emphasizing the detrimental effects and severity of older patients being infected with RSV. Our findings underscore the need for strategic testing and vaccination approaches to mitigate the impact of RSV among older adults.
(Less)
- author
- publishing date
- 2024-10
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Open Forum Infectious Diseases
- volume
- 11
- issue
- 10
- article number
- ofae513
- publisher
- Oxford University Press
- external identifiers
-
- pmid:39411215
- scopus:85207631399
- ISSN
- 2328-8957
- DOI
- 10.1093/ofid/ofae513
- language
- English
- LU publication?
- no
- additional info
- © The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
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- 1de9204d-8252-4245-ad1c-737180c5478d
- date added to LUP
- 2025-01-03 10:00:52
- date last changed
- 2025-07-19 20:43:48
@article{1de9204d-8252-4245-ad1c-737180c5478d,
abstract = {{<p>BACKGROUND: Respiratory syncytial virus (RSV) and influenza cause significant health challenges, particularly for individuals with comorbid conditions and older adults. However, information on the clinical manifestations and outcomes of adults hospitalized with RSV in Europe remains limited.</p><p>METHODS: This multicenter observational cohort study of adults hospitalized with RSV or influenza A or B from March 2016 to April 2020 investigated the clinical manifestations, mortality risk factors, and association with 90-day mortality rates by logistic regression analysis after adjustment for covariates.</p><p>RESULTS: Of 988 patients hospitalized with either virus, 353 had RSV, 347 had influenza A, and 288 had influenza B infection. Patients with RSV, compared with those with influenza A or B, were more likely to have comorbid conditions (83% for RSV vs 72% for influenza A [P = .03] and 74% for influenza B [P = .001]) or pneumonia (41% vs 29% [P = .03] and 24% [P < .001], respectively). After adjustment for covariates, RSV infection was associated with an increased all-cause mortality rate within 90 days compared with influenza B (odds ratio, 2.16 [95% confidence interval, 1.20-3.87]; P = .01) but not influenza A (1.38 [.84-2.29]; P = .21). Increasing age and present pneumonia were identified as independent mortality risk factors in patients with RSV.</p><p>CONCLUSIONS: Older adults hospitalized with RSV infections are at a higher risk of dying within 90 days of hospitalization than patients admitted with influenza B but at a similar risk as those admitted with influenza A, emphasizing the detrimental effects and severity of older patients being infected with RSV. Our findings underscore the need for strategic testing and vaccination approaches to mitigate the impact of RSV among older adults.</p>}},
author = {{Clausen, Clara Lundetoft and Egeskov-Cavling, Amanda Marie and Hayder, Noor and Sejdic, Adin and Roed, Casper and Gitz Holler, Jon and Nielsen, Lene and Eiberg, Mads Frederik and Rezahosseini, Omid and Østergaard, Christian and Harboe, Zitta Barrella and Fischer, Thea K and Benfield, Thomas and Lindegaard, Birgitte}},
issn = {{2328-8957}},
language = {{eng}},
number = {{10}},
publisher = {{Oxford University Press}},
series = {{Open Forum Infectious Diseases}},
title = {{Clinical Manifestations and Outcomes in Adults Hospitalized With Respiratory Syncytial Virus and Influenza a/B : A Multicenter Observational Cohort Study}},
url = {{http://dx.doi.org/10.1093/ofid/ofae513}},
doi = {{10.1093/ofid/ofae513}},
volume = {{11}},
year = {{2024}},
}