CSF and blood biomarkers for Parkinson's disease
Parnetti, Lucilla ; Gaetani, Lorenzo ; Eusebi, Paolo ; Paciotti, Silvia ; Hansson, Oskar LU
; El-Agnaf, Omar
; Mollenhauer, Brit
; Blennow, Kaj
LU
and Calabresi, Paolo
(2019)
In The Lancet Neurology
18(6).
p.573-586
- Abstract
In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urgently needed. The diagnosis of Parkinson's disease mostly relies on clinical symptoms, which hampers the detection of the earliest phases of the disease—the time at which treatment with forthcoming disease-modifying drugs could have the greatest therapeutic effect. Reliable prognostic markers could help in predicting the response to treatments. Evidence suggests potential diagnostic and prognostic value of CSF and blood biomarkers closely reflecting the pathophysiology of Parkinson's disease, such as α-synuclein species, lysosomal enzymes, markers of amyloid and tau pathology, and neurofilament light chain. A combination of multiple CSF... (More)
In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urgently needed. The diagnosis of Parkinson's disease mostly relies on clinical symptoms, which hampers the detection of the earliest phases of the disease—the time at which treatment with forthcoming disease-modifying drugs could have the greatest therapeutic effect. Reliable prognostic markers could help in predicting the response to treatments. Evidence suggests potential diagnostic and prognostic value of CSF and blood biomarkers closely reflecting the pathophysiology of Parkinson's disease, such as α-synuclein species, lysosomal enzymes, markers of amyloid and tau pathology, and neurofilament light chain. A combination of multiple CSF biomarkers has emerged as an accurate diagnostic and prognostic model. With respect to early diagnosis, the measurement of CSF α-synuclein aggregates is providing encouraging preliminary results. Blood α-synuclein species and neurofilament light chain are also under investigation because they would provide a non-invasive tool, both for early and differential diagnosis of Parkinson's disease versus atypical parkinsonian disorders, and for disease monitoring. In view of adopting CSF and blood biomarkers for improving Parkinson's disease diagnostic and prognostic accuracy, further validation in large independent cohorts is needed.
(Less)
- author
- Parnetti, Lucilla
; Gaetani, Lorenzo
; Eusebi, Paolo
; Paciotti, Silvia
; Hansson, Oskar
LU
; El-Agnaf, Omar
; Mollenhauer, Brit
; Blennow, Kaj
LU
and Calabresi, Paolo
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Lancet Neurology
- volume
- 18
- issue
- 6
- pages
- 14 pages
- publisher
- Lancet Publishing Group
- external identifiers
-
- pmid:30981640
- scopus:85065771657
- ISSN
- 1474-4422
- DOI
- 10.1016/S1474-4422(19)30024-9
- language
- English
- LU publication?
- yes
- id
- 1e39b742-db65-4dcd-aca0-1fb79e7a4c0a
- date added to LUP
- 2019-05-28 09:56:20
- date last changed
- 2024-04-16 07:52:54
@article{1e39b742-db65-4dcd-aca0-1fb79e7a4c0a,
abstract = {{<p>In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urgently needed. The diagnosis of Parkinson's disease mostly relies on clinical symptoms, which hampers the detection of the earliest phases of the disease—the time at which treatment with forthcoming disease-modifying drugs could have the greatest therapeutic effect. Reliable prognostic markers could help in predicting the response to treatments. Evidence suggests potential diagnostic and prognostic value of CSF and blood biomarkers closely reflecting the pathophysiology of Parkinson's disease, such as α-synuclein species, lysosomal enzymes, markers of amyloid and tau pathology, and neurofilament light chain. A combination of multiple CSF biomarkers has emerged as an accurate diagnostic and prognostic model. With respect to early diagnosis, the measurement of CSF α-synuclein aggregates is providing encouraging preliminary results. Blood α-synuclein species and neurofilament light chain are also under investigation because they would provide a non-invasive tool, both for early and differential diagnosis of Parkinson's disease versus atypical parkinsonian disorders, and for disease monitoring. In view of adopting CSF and blood biomarkers for improving Parkinson's disease diagnostic and prognostic accuracy, further validation in large independent cohorts is needed.</p>}},
author = {{Parnetti, Lucilla and Gaetani, Lorenzo and Eusebi, Paolo and Paciotti, Silvia and Hansson, Oskar and El-Agnaf, Omar and Mollenhauer, Brit and Blennow, Kaj and Calabresi, Paolo}},
issn = {{1474-4422}},
language = {{eng}},
number = {{6}},
pages = {{573--586}},
publisher = {{Lancet Publishing Group}},
series = {{The Lancet Neurology}},
title = {{CSF and blood biomarkers for Parkinson's disease}},
url = {{http://dx.doi.org/10.1016/S1474-4422(19)30024-9}},
doi = {{10.1016/S1474-4422(19)30024-9}},
volume = {{18}},
year = {{2019}},
}