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Mycoplasma pneumonia with severe cold agglutinin hemolysis, thrombocytosis, leukemoid reaction and acute renal failure

Widén, Johan LU ; Jönsson, Göran LU and Karlsson, Ulf LU (2023) In IDCases 31.
Abstract

Mycoplasma pneumoniae (M. pneumoniae) is a common cause of community acquired pneumonia and although most cases are mild, complications sometimes occur. Cold agglutinin hemolysis is a known complication of M. pneumoniae infection, and usually presents as a mild and transient hemolysis. Here we present a case of infection with M. pneumoniae in a 64-year-old male that caused life threatening hemolysis that required multiple blood transfusions. The patient also presented with acute kidney failure and a marked leukemoid reaction and thrombocytosis. This is a very rare combination of symptoms that could have led the clinicians to suspect a more virulent etiology than M. pneumoniae, thereby delaying adequate antibiotic treatment.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acute kidney failure, Cold-agglutinin hemolysis, Corticosteroids, Leukemoid reaction, Mycoplasma pneumoniae
in
IDCases
volume
31
article number
e01689
publisher
Elsevier
external identifiers
  • pmid:36687368
  • scopus:85146352639
ISSN
2214-2509
DOI
10.1016/j.idcr.2023.e01689
language
English
LU publication?
yes
id
1e4a106d-e5d6-481d-af44-082cd785af2f
date added to LUP
2023-02-15 10:36:19
date last changed
2024-06-13 23:58:29
@article{1e4a106d-e5d6-481d-af44-082cd785af2f,
  abstract     = {{<p>Mycoplasma pneumoniae (M. pneumoniae) is a common cause of community acquired pneumonia and although most cases are mild, complications sometimes occur. Cold agglutinin hemolysis is a known complication of M. pneumoniae infection, and usually presents as a mild and transient hemolysis. Here we present a case of infection with M. pneumoniae in a 64-year-old male that caused life threatening hemolysis that required multiple blood transfusions. The patient also presented with acute kidney failure and a marked leukemoid reaction and thrombocytosis. This is a very rare combination of symptoms that could have led the clinicians to suspect a more virulent etiology than M. pneumoniae, thereby delaying adequate antibiotic treatment.</p>}},
  author       = {{Widén, Johan and Jönsson, Göran and Karlsson, Ulf}},
  issn         = {{2214-2509}},
  keywords     = {{Acute kidney failure; Cold-agglutinin hemolysis; Corticosteroids; Leukemoid reaction; Mycoplasma pneumoniae}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{IDCases}},
  title        = {{Mycoplasma pneumonia with severe cold agglutinin hemolysis, thrombocytosis, leukemoid reaction and acute renal failure}},
  url          = {{http://dx.doi.org/10.1016/j.idcr.2023.e01689}},
  doi          = {{10.1016/j.idcr.2023.e01689}},
  volume       = {{31}},
  year         = {{2023}},
}