Unmanipulated haploidentical stem cell transplantation in adults with acute lymphoblastic leukemia : a study on behalf of the Acute Leukemia Working Party of the EBMT
(2017) In Journal of Hematology & Oncology 10(1).- Abstract
Background: Allogenic hematopoietic stem cell transplantation (allo-SCT) is the most effective post-remission treatment for adults with high-risk acute lymphoblastic leukemia (ALL). The aim of the study was to analyze results of unmanipulated haploidentical allo-SCT (haplo-SCT) for adults with ALL and to identify prognostic factors. Methods: We performed a retrospective analysis on 208 adults transplanted in EBMT centers from 2007 to 2014. Results: Median age at haplo-SCT was 32 years and median follow-up, 31 months. Forty-four percent of the patients were in first complete remission (CR1). Stem cell source was the bone marrow (BM) for 43% and peripheral blood (PB) for 57% of patients. Myeloablative conditioning (MAC) was used for 66%... (More)
Background: Allogenic hematopoietic stem cell transplantation (allo-SCT) is the most effective post-remission treatment for adults with high-risk acute lymphoblastic leukemia (ALL). The aim of the study was to analyze results of unmanipulated haploidentical allo-SCT (haplo-SCT) for adults with ALL and to identify prognostic factors. Methods: We performed a retrospective analysis on 208 adults transplanted in EBMT centers from 2007 to 2014. Results: Median age at haplo-SCT was 32 years and median follow-up, 31 months. Forty-four percent of the patients were in first complete remission (CR1). Stem cell source was the bone marrow (BM) for 43% and peripheral blood (PB) for 57% of patients. Myeloablative conditioning (MAC) was used for 66% and reduced intensity regimen (RIC) for 34% of patients. GVHD prophylaxis was based on post-transplant cyclophosphamide (PT-Cy) for 118 (57%) or on anti-thymocyte-globulin (ATG) for 90 (43%) plus standard prophylaxis. One hundred eighty-four (92%) patients achieved engraftment. Cumulative incidence (CI) of grade II-IV acute-graft-versus-host-disease (GVHD) was 31%, grade III-IV 11%, and chronic GVHD 29%. Non-relapse mortality (NRM) and relapse-incidence (RI) were 32 and 37%, respectively. Overall survival (OS), leukemia-free survival (LFS), and GVHD-free, relapse-free-survival (GRFS) at 3 years were 33, 31, and 26%. For patients in CR1, OS, LFS, and GRFS were 52, 47, and 40%, respectively. Disease status was the main factor associated with transplant outcomes. Use of BM was independently associated with improvement in NRM, acute GVHD, GRFS, LFS, and OS. Conclusions: Unmanipulated haplo-SCT may be considered a valid option for adult patients with high-risk ALL lacking HLA identical donor preferably in early disease status.
(Less)
- author
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acute lymphoblastic leukemia, Adults, Allogenic stem cell transplantation, Non-TCD haploidentical
- in
- Journal of Hematology & Oncology
- volume
- 10
- issue
- 1
- article number
- 113
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85019733626
- pmid:28558762
- ISSN
- 1756-8722
- DOI
- 10.1186/s13045-017-0480-5
- language
- English
- LU publication?
- no
- id
- 1e53cd4b-38c8-4331-9233-468e1d3117d9
- date added to LUP
- 2020-04-23 10:16:35
- date last changed
- 2024-04-17 08:38:31
@article{1e53cd4b-38c8-4331-9233-468e1d3117d9,
abstract = {{<p>Background: Allogenic hematopoietic stem cell transplantation (allo-SCT) is the most effective post-remission treatment for adults with high-risk acute lymphoblastic leukemia (ALL). The aim of the study was to analyze results of unmanipulated haploidentical allo-SCT (haplo-SCT) for adults with ALL and to identify prognostic factors. Methods: We performed a retrospective analysis on 208 adults transplanted in EBMT centers from 2007 to 2014. Results: Median age at haplo-SCT was 32 years and median follow-up, 31 months. Forty-four percent of the patients were in first complete remission (CR1). Stem cell source was the bone marrow (BM) for 43% and peripheral blood (PB) for 57% of patients. Myeloablative conditioning (MAC) was used for 66% and reduced intensity regimen (RIC) for 34% of patients. GVHD prophylaxis was based on post-transplant cyclophosphamide (PT-Cy) for 118 (57%) or on anti-thymocyte-globulin (ATG) for 90 (43%) plus standard prophylaxis. One hundred eighty-four (92%) patients achieved engraftment. Cumulative incidence (CI) of grade II-IV acute-graft-versus-host-disease (GVHD) was 31%, grade III-IV 11%, and chronic GVHD 29%. Non-relapse mortality (NRM) and relapse-incidence (RI) were 32 and 37%, respectively. Overall survival (OS), leukemia-free survival (LFS), and GVHD-free, relapse-free-survival (GRFS) at 3 years were 33, 31, and 26%. For patients in CR1, OS, LFS, and GRFS were 52, 47, and 40%, respectively. Disease status was the main factor associated with transplant outcomes. Use of BM was independently associated with improvement in NRM, acute GVHD, GRFS, LFS, and OS. Conclusions: Unmanipulated haplo-SCT may be considered a valid option for adult patients with high-risk ALL lacking HLA identical donor preferably in early disease status.</p>}},
author = {{Santoro, Nicole and Ruggeri, Annalisa and Labopin, Myriam and Bacigalupo, Andrea and Ciceri, Fabio and Gülbaş, Zafer and Huang, He and Afanasyev, Boris and Arcese, William and Wu, Depei and Koc, Yener and Tischer, Johanna and Santarone, Stella and Giebel, Sebastian and Mohty, Mohamad and Nagler, Arnon}},
issn = {{1756-8722}},
keywords = {{Acute lymphoblastic leukemia; Adults; Allogenic stem cell transplantation; Non-TCD haploidentical}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{Journal of Hematology & Oncology}},
title = {{Unmanipulated haploidentical stem cell transplantation in adults with acute lymphoblastic leukemia : a study on behalf of the Acute Leukemia Working Party of the EBMT}},
url = {{http://dx.doi.org/10.1186/s13045-017-0480-5}},
doi = {{10.1186/s13045-017-0480-5}},
volume = {{10}},
year = {{2017}},
}