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A prospective study of positron emission tomography for evaluation of neck node response 6 weeks after radiotherapy in patients with head and neck squamous cell carcinoma.

Sjövall, Johanna LU ; Wahlberg, Peter LU ; Almquist, Helen ; Kjellén, Elisabeth LU and Brun, Eva LU (2015) In Head and Neck
Abstract
Background: The purpose of this study was to evaluate if a positron emission tomography (PET) scan, 6 weeks post radiotherapy (RT), adequately selects patients in whom a neck node dissection can be omitted. Primary endpoints were isolated neck recurrences and overall survival (OS). Methods: 105 patients, mainly with oropharyngeal human papilloma virus (HPV) positive tumors, with a positive PET scan before treatment, were evaluated regarding the neck response 6 weeks post RT. The PET results determined the management of the neck: observation vs. neck dissection. Results: Median follow-up was 25 months. Positive predictive value (PPV) and negative predictive value (NPV) were 56% and 94%, respectively. Four isolated neck recurrences occurred.... (More)
Background: The purpose of this study was to evaluate if a positron emission tomography (PET) scan, 6 weeks post radiotherapy (RT), adequately selects patients in whom a neck node dissection can be omitted. Primary endpoints were isolated neck recurrences and overall survival (OS). Methods: 105 patients, mainly with oropharyngeal human papilloma virus (HPV) positive tumors, with a positive PET scan before treatment, were evaluated regarding the neck response 6 weeks post RT. The PET results determined the management of the neck: observation vs. neck dissection. Results: Median follow-up was 25 months. Positive predictive value (PPV) and negative predictive value (NPV) were 56% and 94%, respectively. Four isolated neck recurrences occurred. The 2 year OS rate was 86.3%. Conclusion: PET scans performed 6 weeks after RT have a high NPV and can obviate neck dissections but the PPV is insufficient. A later scheduled scan is recommended. This article is protected by copyright. All rights reserved. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Head and Neck
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:25716933
  • scopus:84938880630
  • pmid:25716933
  • wos:000375116400050
ISSN
1043-3074
DOI
10.1002/hed.24021
language
English
LU publication?
yes
id
1e674bce-7954-4555-87fd-d7d82e59bc7c (old id 5142660)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25716933?dopt=Abstract
date added to LUP
2016-04-04 07:42:44
date last changed
2022-03-15 07:19:43
@article{1e674bce-7954-4555-87fd-d7d82e59bc7c,
  abstract     = {{Background: The purpose of this study was to evaluate if a positron emission tomography (PET) scan, 6 weeks post radiotherapy (RT), adequately selects patients in whom a neck node dissection can be omitted. Primary endpoints were isolated neck recurrences and overall survival (OS). Methods: 105 patients, mainly with oropharyngeal human papilloma virus (HPV) positive tumors, with a positive PET scan before treatment, were evaluated regarding the neck response 6 weeks post RT. The PET results determined the management of the neck: observation vs. neck dissection. Results: Median follow-up was 25 months. Positive predictive value (PPV) and negative predictive value (NPV) were 56% and 94%, respectively. Four isolated neck recurrences occurred. The 2 year OS rate was 86.3%. Conclusion: PET scans performed 6 weeks after RT have a high NPV and can obviate neck dissections but the PPV is insufficient. A later scheduled scan is recommended. This article is protected by copyright. All rights reserved.}},
  author       = {{Sjövall, Johanna and Wahlberg, Peter and Almquist, Helen and Kjellén, Elisabeth and Brun, Eva}},
  issn         = {{1043-3074}},
  language     = {{eng}},
  month        = {{02}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Head and Neck}},
  title        = {{A prospective study of positron emission tomography for evaluation of neck node response 6 weeks after radiotherapy in patients with head and neck squamous cell carcinoma.}},
  url          = {{http://dx.doi.org/10.1002/hed.24021}},
  doi          = {{10.1002/hed.24021}},
  year         = {{2015}},
}