Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides
(1998) In Nature Medicine 4(4). p.447-451- Abstract
Alzheimer's disease (AD) is characterized by the accumulation of cerebral plaques composed of 40- and 42-amino acid ̄-amyloid (Aβ) peptides, and autosomal dominant forms of AD appear to cause disease by promoting brain Aβ accumulation. Recent studies indicate that postmenopausal estrogen replacement therapy may prevent or delay the onset of AD. Here we present evidence that physiological levels of 17β-estradiol reduce the generation of Aβ by neuroblastoma cells and by primary cultures of rat, mouse and human embryonic cerebrocortical neurons. These results suggest a mechanism by which estrogen replacement therapy can delay or prevent AD.
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- author
- publishing date
- 1998-04-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Medicine
- volume
- 4
- issue
- 4
- pages
- 447 - 451
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:9546791
- scopus:0031946864
- ISSN
- 1078-8956
- DOI
- 10.1038/nm0498-447
- language
- English
- LU publication?
- no
- id
- 1ea2a08a-e65b-4b85-bdf6-c754ddc5ff0e
- date added to LUP
- 2020-02-20 14:29:11
- date last changed
- 2024-04-03 03:10:34
@article{1ea2a08a-e65b-4b85-bdf6-c754ddc5ff0e, abstract = {{<p>Alzheimer's disease (AD) is characterized by the accumulation of cerebral plaques composed of 40- and 42-amino acid ̄-amyloid (Aβ) peptides, and autosomal dominant forms of AD appear to cause disease by promoting brain Aβ accumulation. Recent studies indicate that postmenopausal estrogen replacement therapy may prevent or delay the onset of AD. Here we present evidence that physiological levels of 17β-estradiol reduce the generation of Aβ by neuroblastoma cells and by primary cultures of rat, mouse and human embryonic cerebrocortical neurons. These results suggest a mechanism by which estrogen replacement therapy can delay or prevent AD.</p>}}, author = {{Xu, Huaxi and Gouras, Gunnar K. and Greenfield, Jeffrey P. and Vincent, Bruno and Naslund, Jan and Mazzarelli, Louis and Fried, Gabriel and Jovanovic, Jasmina N. and Seeger, Mary and Relkin, Norman R. and Liao, Fang and Checler, Frédéric and Buxbaum, Joseph D. and Chait, Brian T. and Thinakaran, Gopal and Sisodia, Sangram S. and Wang, Rong and Greengard, Paul and Gandy, Sam}}, issn = {{1078-8956}}, language = {{eng}}, month = {{04}}, number = {{4}}, pages = {{447--451}}, publisher = {{Nature Publishing Group}}, series = {{Nature Medicine}}, title = {{Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides}}, url = {{http://dx.doi.org/10.1038/nm0498-447}}, doi = {{10.1038/nm0498-447}}, volume = {{4}}, year = {{1998}}, }