Specialized pro-resolving mediators and the lymphatic system
(2021) In International Journal of Molecular Sciences 22(5). p.1-17- Abstract
Diminished lymphatic function and abnormal morphology are common in chronic inflammatory diseases. Recent studies are investigating whether it is possible to target chronic inflammation by promoting resolution of inflammation, in order to enhance lymphatic function and attenuate disease. Resolution of inflammation is an active process regulated by bioactive lipids known as specialized pro-resolving mediators (SPMs). SPMs can modulate leukocyte migration and function, alter cytokine/chemokine release, modify autophagy, among other immune-related activities. Here, we summarize the role of the lymphatics in resolution of inflammation and lymphatic impairment in chronic inflammatory diseases. Furthermore, we discuss the current literature... (More)
Diminished lymphatic function and abnormal morphology are common in chronic inflammatory diseases. Recent studies are investigating whether it is possible to target chronic inflammation by promoting resolution of inflammation, in order to enhance lymphatic function and attenuate disease. Resolution of inflammation is an active process regulated by bioactive lipids known as specialized pro-resolving mediators (SPMs). SPMs can modulate leukocyte migration and function, alter cytokine/chemokine release, modify autophagy, among other immune-related activities. Here, we summarize the role of the lymphatics in resolution of inflammation and lymphatic impairment in chronic inflammatory diseases. Furthermore, we discuss the current literature describing the connection between SPMs and the lymphatics, and the possibility of targeting the lymphatics with innovative SPM therapy to promote resolution of inflammation and mitigate disease.
(Less)
- author
- Kraft, Jamie D. ; Blomgran, Robert ; Lundgaard, Iben LU ; Quiding-Järbrink, Marianne ; Bromberg, Jonathan S. and Börgeson, Emma
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Atherosclerosis, Dry eye disease, Inflammatory bowel disease, Lymphatics, Lymphoid organs, Resolution of inflammation, Specialized pro-resolving mediators (SPMs)
- in
- International Journal of Molecular Sciences
- volume
- 22
- issue
- 5
- article number
- 2750
- pages
- 17 pages
- publisher
- MDPI AG
- external identifiers
-
- pmid:33803130
- scopus:85102107353
- ISSN
- 1661-6596
- DOI
- 10.3390/ijms22052750
- language
- English
- LU publication?
- yes
- id
- 1eb509e5-3c84-46cf-b38a-663dd40eab4d
- date added to LUP
- 2021-03-17 08:28:15
- date last changed
- 2024-04-04 01:41:13
@article{1eb509e5-3c84-46cf-b38a-663dd40eab4d,
abstract = {{<p>Diminished lymphatic function and abnormal morphology are common in chronic inflammatory diseases. Recent studies are investigating whether it is possible to target chronic inflammation by promoting resolution of inflammation, in order to enhance lymphatic function and attenuate disease. Resolution of inflammation is an active process regulated by bioactive lipids known as specialized pro-resolving mediators (SPMs). SPMs can modulate leukocyte migration and function, alter cytokine/chemokine release, modify autophagy, among other immune-related activities. Here, we summarize the role of the lymphatics in resolution of inflammation and lymphatic impairment in chronic inflammatory diseases. Furthermore, we discuss the current literature describing the connection between SPMs and the lymphatics, and the possibility of targeting the lymphatics with innovative SPM therapy to promote resolution of inflammation and mitigate disease.</p>}},
author = {{Kraft, Jamie D. and Blomgran, Robert and Lundgaard, Iben and Quiding-Järbrink, Marianne and Bromberg, Jonathan S. and Börgeson, Emma}},
issn = {{1661-6596}},
keywords = {{Atherosclerosis; Dry eye disease; Inflammatory bowel disease; Lymphatics; Lymphoid organs; Resolution of inflammation; Specialized pro-resolving mediators (SPMs)}},
language = {{eng}},
number = {{5}},
pages = {{1--17}},
publisher = {{MDPI AG}},
series = {{International Journal of Molecular Sciences}},
title = {{Specialized pro-resolving mediators and the lymphatic system}},
url = {{http://dx.doi.org/10.3390/ijms22052750}},
doi = {{10.3390/ijms22052750}},
volume = {{22}},
year = {{2021}},
}