Effect of UGT2B7-900G > A (-842G > A; rs7438135) on morphine glucuronidation in preterm newborns: results from a pilot cohort
Matic, Maja ; Norman, Elisabeth LU ; Rane, Anders ; Beck, Olof ; Andersson, Maria ; Elens, Laure ; Tibboel, Dick ; Fellman, Vineta LU
and van Schaik, Ron H. N.
(2014)
In Pharmacogenomics
15(12).
p.1589-1597
- Abstract
- Aim: Assess association between UGT2B7 polymorphism -900G>A (rs7438135, also known as -842G>A) with morphine kinetics in preterm newborns undergoing mechanical ventilation. Materials & methods: Thirty-four infants were enrolled in a randomized clinical trial and allocated to rapid sequence intubation with remifentanil (1 mu g/kg) or morphine (0.3 mg/kg). The latter group was included in our study. Results: Morphine plasma concentrations at 20 min post intubation were associated with postnatal age (p = 0.017) and UGT2B7 -900G>A (p = 0.036). UGT2B7 -900A allele carriers (n = 13) had lower morphine levels compared with UGT2B7 -900G/G patients (n = 2). Morphine-3-glucuronide and morphine-6-glucuronide plasma concentrations were... (More)
- Aim: Assess association between UGT2B7 polymorphism -900G>A (rs7438135, also known as -842G>A) with morphine kinetics in preterm newborns undergoing mechanical ventilation. Materials & methods: Thirty-four infants were enrolled in a randomized clinical trial and allocated to rapid sequence intubation with remifentanil (1 mu g/kg) or morphine (0.3 mg/kg). The latter group was included in our study. Results: Morphine plasma concentrations at 20 min post intubation were associated with postnatal age (p = 0.017) and UGT2B7 -900G>A (p = 0.036). UGT2B7 -900A allele carriers (n = 13) had lower morphine levels compared with UGT2B7 -900G/G patients (n = 2). Morphine-3-glucuronide and morphine-6-glucuronide plasma concentrations were only found to be associated with gestational and postnatal age. However, -900A allele carriers had a higher morphine-3-glucuronide: morphine metabolic ratio compared with patients genotyped as -900G/G (p = 0.005), as determined by linear regression. Conclusion: Our small pilot study illustrates that in addition to gestational and postnatal age, the UGT2B7 -900G>A polymorphism significantly alters morphine pharmacokinetics in preterm infants. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4875960
- author
- Matic, Maja
; Norman, Elisabeth
LU
; Rane, Anders
; Beck, Olof
; Andersson, Maria
; Elens, Laure
; Tibboel, Dick
; Fellman, Vineta
LU
and van Schaik, Ron H. N.
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- morphine, newborns, pharmacokinetics, polymorphism, UGT2B7, ventilation
- in
- Pharmacogenomics
- volume
- 15
- issue
- 12
- pages
- 1589 - 1597
- publisher
- Future Medicine Ltd.
- external identifiers
-
- wos:000344180300005
- scopus:84908139332
- ISSN
- 1462-2416
- DOI
- 10.2217/PGS.14.115
- language
- English
- LU publication?
- yes
- id
- 1ef01f8d-7b39-490e-a04e-9df396af97f1 (old id 4875960)
- date added to LUP
- 2016-04-01 10:36:13
- date last changed
- 2022-02-02 19:20:23
@article{1ef01f8d-7b39-490e-a04e-9df396af97f1,
abstract = {{Aim: Assess association between UGT2B7 polymorphism -900G>A (rs7438135, also known as -842G>A) with morphine kinetics in preterm newborns undergoing mechanical ventilation. Materials & methods: Thirty-four infants were enrolled in a randomized clinical trial and allocated to rapid sequence intubation with remifentanil (1 mu g/kg) or morphine (0.3 mg/kg). The latter group was included in our study. Results: Morphine plasma concentrations at 20 min post intubation were associated with postnatal age (p = 0.017) and UGT2B7 -900G>A (p = 0.036). UGT2B7 -900A allele carriers (n = 13) had lower morphine levels compared with UGT2B7 -900G/G patients (n = 2). Morphine-3-glucuronide and morphine-6-glucuronide plasma concentrations were only found to be associated with gestational and postnatal age. However, -900A allele carriers had a higher morphine-3-glucuronide: morphine metabolic ratio compared with patients genotyped as -900G/G (p = 0.005), as determined by linear regression. Conclusion: Our small pilot study illustrates that in addition to gestational and postnatal age, the UGT2B7 -900G>A polymorphism significantly alters morphine pharmacokinetics in preterm infants.}},
author = {{Matic, Maja and Norman, Elisabeth and Rane, Anders and Beck, Olof and Andersson, Maria and Elens, Laure and Tibboel, Dick and Fellman, Vineta and van Schaik, Ron H. N.}},
issn = {{1462-2416}},
keywords = {{morphine; newborns; pharmacokinetics; polymorphism; UGT2B7; ventilation}},
language = {{eng}},
number = {{12}},
pages = {{1589--1597}},
publisher = {{Future Medicine Ltd.}},
series = {{Pharmacogenomics}},
title = {{Effect of UGT2B7-900G > A (-842G > A; rs7438135) on morphine glucuronidation in preterm newborns: results from a pilot cohort}},
url = {{http://dx.doi.org/10.2217/PGS.14.115}},
doi = {{10.2217/PGS.14.115}},
volume = {{15}},
year = {{2014}},
}