High-level RNA editing diversifies the coleoid cephalopod brain proteome
Voss, Gjendine LU
and Rosenthal, Joshua J.C.
(2023)
In Briefings in Functional Genomics
22(6).
p.525-532
- Abstract
Coleoid cephalopods (octopus, squid and cuttlefish) have unusually complex nervous systems. The coleoid nervous system is also the only one currently known to recode the majority of expressed proteins through A-to-I RNA editing. The deamination of adenosine by adenosine deaminase acting on RNA (ADAR) enzymes produces inosine, which is interpreted as guanosine during translation. If this occurs in an open reading frame, which is the case for tens of thousands of editing sites in coleoids, it can recode the encoded protein. Here, we describe recent findings aimed at deciphering the mechanisms underlying high-level recoding and its adaptive potential. We describe the complement of ADAR enzymes in cephalopods, including a recently... (More)
Coleoid cephalopods (octopus, squid and cuttlefish) have unusually complex nervous systems. The coleoid nervous system is also the only one currently known to recode the majority of expressed proteins through A-to-I RNA editing. The deamination of adenosine by adenosine deaminase acting on RNA (ADAR) enzymes produces inosine, which is interpreted as guanosine during translation. If this occurs in an open reading frame, which is the case for tens of thousands of editing sites in coleoids, it can recode the encoded protein. Here, we describe recent findings aimed at deciphering the mechanisms underlying high-level recoding and its adaptive potential. We describe the complement of ADAR enzymes in cephalopods, including a recently discovered novel domain in sqADAR1. We further summarize current evidence supporting an adaptive role of high-level RNA recoding in coleoids, and review recent studies showing that a large proportion of recoding sites is temperature-sensitive. Despite these new findings, the mechanisms governing the high level of RNA recoding in coleoid cephalopods remain poorly understood. Recent advances using genome editing in squid may provide useful tools to further study A-to-I RNA editing in these animals.
(Less)
- author
- Voss, Gjendine
LU
and Rosenthal, Joshua J.C.
- publishing date
- 2023-11-01
- type
- Contribution to journal
- publication status
- published
- keywords
- ADAR, cephalopods, octopus, RNA editing, squid
- in
- Briefings in Functional Genomics
- volume
- 22
- issue
- 6
- pages
- 525 - 532
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85177756242
- pmid:37981860
- ISSN
- 2041-2649
- DOI
- 10.1093/bfgp/elad034
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © The Author(s) 2023. Published by Oxford University Press. All rights reserved.
- id
- 1f015988-8112-4912-bad7-96cb39307b39
- date added to LUP
- 2025-12-02 09:03:08
- date last changed
- 2025-12-03 03:22:48
@article{1f015988-8112-4912-bad7-96cb39307b39,
abstract = {{<p>Coleoid cephalopods (octopus, squid and cuttlefish) have unusually complex nervous systems. The coleoid nervous system is also the only one currently known to recode the majority of expressed proteins through A-to-I RNA editing. The deamination of adenosine by adenosine deaminase acting on RNA (ADAR) enzymes produces inosine, which is interpreted as guanosine during translation. If this occurs in an open reading frame, which is the case for tens of thousands of editing sites in coleoids, it can recode the encoded protein. Here, we describe recent findings aimed at deciphering the mechanisms underlying high-level recoding and its adaptive potential. We describe the complement of ADAR enzymes in cephalopods, including a recently discovered novel domain in sqADAR1. We further summarize current evidence supporting an adaptive role of high-level RNA recoding in coleoids, and review recent studies showing that a large proportion of recoding sites is temperature-sensitive. Despite these new findings, the mechanisms governing the high level of RNA recoding in coleoid cephalopods remain poorly understood. Recent advances using genome editing in squid may provide useful tools to further study A-to-I RNA editing in these animals.</p>}},
author = {{Voss, Gjendine and Rosenthal, Joshua J.C.}},
issn = {{2041-2649}},
keywords = {{ADAR; cephalopods; octopus; RNA editing; squid}},
language = {{eng}},
month = {{11}},
number = {{6}},
pages = {{525--532}},
publisher = {{Oxford University Press}},
series = {{Briefings in Functional Genomics}},
title = {{High-level RNA editing diversifies the coleoid cephalopod brain proteome}},
url = {{http://dx.doi.org/10.1093/bfgp/elad034}},
doi = {{10.1093/bfgp/elad034}},
volume = {{22}},
year = {{2023}},
}