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Pericyte secretome

Gaceb, Abderahim LU and Paul, Gesine LU (2018) In Advances in Experimental Medicine and Biology 1109. p.139-163
Abstract

The role of pericytes seems to extend beyond their known function in angiogenesis, fibrosis and wound healing, blood-brain barrier maintenance, and blood flow regulation. More and more data are currently accumulating indicating that pericytes, uniquely positioned at the interface between blood and parenchyma, secrete a large plethora of different molecules in response to microenvironmental changes. Their secretome is tissue-specific and stimulus-specific and includes pro- and anti-inflammatory factors, growth factors, and extracellular matrix as well as microvesicles suggesting the important role of pericytes in the regulation of immune response and immune evasion of tumors. However, the angiogenic and trophic secretome of pericytes... (More)

The role of pericytes seems to extend beyond their known function in angiogenesis, fibrosis and wound healing, blood-brain barrier maintenance, and blood flow regulation. More and more data are currently accumulating indicating that pericytes, uniquely positioned at the interface between blood and parenchyma, secrete a large plethora of different molecules in response to microenvironmental changes. Their secretome is tissue-specific and stimulus-specific and includes pro- and anti-inflammatory factors, growth factors, and extracellular matrix as well as microvesicles suggesting the important role of pericytes in the regulation of immune response and immune evasion of tumors. However, the angiogenic and trophic secretome of pericytes indicates that their secretome plays a role in physiological homeostasis but possibly also in disease progression or could be exploited for regenerative processes in the future. This book chapter summarizes the current data on the secretory properties of pericytes from different tissues in response to certain pathological stimuli such as inflammatory stimuli, hypoxia, high glucose, and others and thereby aims to provide insights into the possible role of pericytes in these conditions.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Angiogenesis, Blood-brain barrier, Chemokines, Cytokines, Growth factor, Inflammation, Microvesicles, Pericytes, Regeneration, Secretome
host publication
Pericyte Biology - Novel Concepts
series title
Advances in Experimental Medicine and Biology
volume
1109
pages
25 pages
publisher
Springer
external identifiers
  • scopus:85058595249
ISSN
0065-2598
2214-8019
DOI
10.1007/978-3-030-02601-1_11
language
English
LU publication?
yes
id
1f12382e-3335-44c8-b6f8-5307a71c292d
date added to LUP
2019-01-08 14:06:38
date last changed
2019-09-27 13:07:32
@inbook{1f12382e-3335-44c8-b6f8-5307a71c292d,
  abstract     = {<p>The role of pericytes seems to extend beyond their known function in angiogenesis, fibrosis and wound healing, blood-brain barrier maintenance, and blood flow regulation. More and more data are currently accumulating indicating that pericytes, uniquely positioned at the interface between blood and parenchyma, secrete a large plethora of different molecules in response to microenvironmental changes. Their secretome is tissue-specific and stimulus-specific and includes pro- and anti-inflammatory factors, growth factors, and extracellular matrix as well as microvesicles suggesting the important role of pericytes in the regulation of immune response and immune evasion of tumors. However, the angiogenic and trophic secretome of pericytes indicates that their secretome plays a role in physiological homeostasis but possibly also in disease progression or could be exploited for regenerative processes in the future. This book chapter summarizes the current data on the secretory properties of pericytes from different tissues in response to certain pathological stimuli such as inflammatory stimuli, hypoxia, high glucose, and others and thereby aims to provide insights into the possible role of pericytes in these conditions.</p>},
  author       = {Gaceb, Abderahim and Paul, Gesine},
  issn         = {0065-2598},
  keyword      = {Angiogenesis,Blood-brain barrier,Chemokines,Cytokines,Growth factor,Inflammation,Microvesicles,Pericytes,Regeneration,Secretome},
  language     = {eng},
  pages        = {139--163},
  publisher    = {Springer},
  series       = {Advances in Experimental Medicine and Biology},
  title        = {Pericyte secretome},
  url          = {http://dx.doi.org/10.1007/978-3-030-02601-1_11},
  volume       = {1109},
  year         = {2018},
}